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Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry

Objective

Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into cells and tissues. These limitations will be addressed through the original and innovative approach of the ClickGene network.

ClickGene’s research objectives are to train 14 ESRs in the field of biomaterials development with specific focus on, i.) site-selective genetic engineering, ii.) liposomal nanoparticle drug delivery, and iii.) optogenetic diagnostic probes for epigenetic base detection. Most of our academic partners are key members of COST Action CM1201: Biomimetic Radical Chemistry and all have outstanding international reputations as scientific leaders in their field. This COST Action will play a vital role in both networking and training elements of ClickGene, and in combination with transferable skills training, intersectorial and cross-disciplinary secondment, and industry targeted workshops, the education of biomaterials chemists with expertise in click-chemistry and cutting edge application areas of gene therapy, nanotechnology and biological diagnostics will be achieved.

The training provided will match the skills required by next-generation research leaders in biopharmaceutical, nanotechnology, biodiagnostic and other industries. Allied to academic strength in this network, ClickGene features highlycompetitive industry partners with expertise in commercialisation of nucleic acid click-chemistry (baseclick, ATDBio) and liposomal and lipidome technology (LipiNutraGen). Thus, synergy between both commercial and academic partners will enable ESRs to develop gene-targeted technology within a highly productive, engaging, and exciting training network.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /engineering and technology/nanotechnology
  • /engineering and technology/industrial biotechnology/biomaterials
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/medical biotechnology/genetic engineering

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DUBLIN CITY UNIVERSITY
Address
Glasnevin
9 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 797 023,80

Participants (8)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 498 432,96
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 273 287,88
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Greece
EU contribution
€ 484 773,84
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 258 061,32
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Czechia
EU contribution
€ 464 844,96
Address
Flemingovo Nam. 542/2
16610 Praha 6
Activity type
Research Organisations
ATDBIO LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
The Square Fawley
SO45 1DD Southampton Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BASECLICK GMBH
Germany
EU contribution
€ 249 216,48
Address
Floriansbogen 2-4
82061 Neuried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIPINUTRAGEN SOCIETA A RESPONSABILITA LIMITATA
Italy
EU contribution
€ 258 061,32
Address
Via Corticella 181/4
40128 Bologna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (9)

ACCELOPMENT SCHWEIZ AG
Switzerland
Address
Seefeldstrasse 198
8008 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
metabion GmbH
Germany
Address
Semmelweisstr. 3
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Link Technologies Ltd
United Kingdom
Address

Bellshill
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Peakdale Molecular Limited
United Kingdom
Address
Sheffield Road
SK23 0PG Chapel-en-le-frith
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LipiNutraMed Ltd
Greece
Address
Patriarchou Grigoriou (Tespa Lefkippos, Ncsr Demokritos)
15310 Aghia Paraskevi, Athens
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA
Greece
Address
Heroon Polytechniou 9 Zographou Campus
15780 Athina
Activity type
Higher or Secondary Education Establishments
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
UNIVERZITA KARLOVA
Czechia
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments