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Research Training Network on Integrated Component Cycling in Epithelial Cell Motility



• Workshop 6: • evaluating need and options for continuation of training and research in the field of cell migration • presenting results to the scientific community and press


• workshop 5: • discussing results with international experts

PhD theses

• submitting and defending PhD theses

Communication 1

• communicating results in publications and at international meetings


Unbiased pattern analysis reveals highly diverse responses of cytoskeletal systems to cyclic straining

Author(s): Ronald Springer, Alexander Zielinski, Catharina Pleschka, Bernd Hoffmann, Rudolf Merkel
Published in: PLOS ONE, Issue 14/3, 2019, Page(s) e0210570, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0210570

Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network

Author(s): Dominic Kamps, Johannes Koch, Victor O. Juma, Eduard Campillo-Funollet, Melanie Graessl, Soumya Banerjee, Tomáš Mazel, Xi Chen, Yao-Wen Wu, Stephanie Portet, Anotida Madzvamuse, Perihan Nalbant, Leif Dehmelt
Published in: Cell Reports, Issue 33/9, 2020, Page(s) 108467, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108467

A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration

Author(s): Laura Murphy, Anotida Madzvamuse
Published in: Applied Numerical Mathematics, Issue 158, 2020, Page(s) 336-359, ISSN 0168-9274
Publisher: Elsevier BV
DOI: 10.1016/j.apnum.2020.08.004

Integrating Actin and Myosin II in a Viscous Model for Cell Migration

Author(s): Anotida Madzvamuse, Benard Kipchumba Kiplangat
Published in: Frontiers in Applied Mathematics and Statistics, Issue 6, 2020, ISSN 2297-4687
Publisher: Frontiers
DOI: 10.3389/fams.2020.00026

Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates

Author(s): Wenhong Li, Ana Sancho, Wen-Lu Chung, Yaron Vinik, Jürgen Groll, Yehiel Zick, Ohad Medalia, Alexander D. Bershadsky, Benjamin Geiger
Published in: Journal of Cell Science, Issue 134/8, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.252221

Projected Finite Elements for Systems of Reaction-Diffusion Equations on Closed Evolving Spheroidal Surfaces

Author(s): Necibe Tuncer, Anotida Madzvamuse
Published in: Communications in Computational Physics, Issue 21/3, 2017, Page(s) 718-747, ISSN 1815-2406
Publisher: Global Science Press
DOI: 10.4208/cicp.oa-2016-0029

Parameter identification through mode isolation for reaction–diffusion systems on arbitrary geometries

Author(s): Laura Murphy, Chandrasekhar Venkataraman, Anotida Madzvamuse
Published in: International Journal of Biomathematics, Issue 11/04, 2018, Page(s) 1850053, ISSN 1793-5245
Publisher: World Scientific Publishing Co. Pte Ltd
DOI: 10.1142/s1793524518500535

An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model

Author(s): Gheed Al-Hity, FengWei Yang, Eduard Campillo-Funollet, Andrew E. Greenstein, Hazel Hunt, Myrthe Mampay, Haya Intabli, Marta Falcinelli, Anotida Madzvamuse, Chandrasekhar Venkataraman, Melanie S. Flint
Published in: Communications Biology, Issue 4/1, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02296-7

Advanced 2D/3D cell migration assay for faster evaluation of chemotaxis of slow-moving cells

Author(s): Lea Tomasova, Zeno Guttenberg, Bernd Hoffmann, Rudolf Merkel
Published in: PLOS ONE, Issue 14/7, 2019, Page(s) e0219708, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0219708

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Author(s): Maria Alieva, Andreia S. Margarido, Tamara Wieles, Erik R. Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J. Snijders, Marike L. Broekman, Jacco van Rheenen
Published in: Scientific Reports, Issue 7/1, 2017, Page(s) 7529, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-07660-4

Lumped finite elements for reaction–cross-diffusion systems on stationary surfaces

Author(s): Massimo Frittelli, Anotida Madzvamuse, Ivonne Sgura, Chandrasekhar Venkataraman
Published in: Computers & Mathematics with Applications, Issue 74/12, 2017, Page(s) 3008-3023, ISSN 0898-1221
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.camwa.2017.07.044

Bulk-surface virtual element method for systems of PDEs in two-space dimensions

Author(s): Massimo Frittelli, Anotida Madzvamuse, Ivonne Sgura
Published in: Numerische Mathematik, Issue 147/2, 2021, Page(s) 305-348, ISSN 0029-599X
Publisher: Springer Verlag
DOI: 10.1007/s00211-020-01167-3

Stability Analysis and Parameter Classification of a Reaction-Diffusion Model on an Annulus

Author(s): Wakil Sarfaraz, Anotida Madzvamuse
Published in: Journal of Applied Nonlinear Dynamics, Issue 9/4, 2020, Page(s) 589-617, ISSN 2164-6457
Publisher: L&H Scientific Publishing
DOI: 10.5890/jand.2020.12.006

Classification of parameter spaces for a reaction-diffusion model on stationary domains

Author(s): Wakil Sarfaraz, Anotida Madzvamuse
Published in: Chaos, Solitons & Fractals, Issue 103, 2017, Page(s) 33-51, ISSN 0960-0779
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chaos.2017.05.032

Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation

Author(s): Barbara Noethel, Lena Ramms, Georg Dreissen, Marco Hoffmann, Ronald Springer, Matthias Rübsam, Wolfgang H. Ziegler, Carien M. Niessen, Rudolf Merkel, Bernd Hoffmann
Published in: Molecular Biology of the Cell, Issue 29/19, 2018, Page(s) 2317-2325, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e17-06-0387

Nanoscale Topography and Poroelastic Properties of Model Tissue Breast Gland Basement Membranes

Author(s): Gloria Fabris, Alessandro Lucantonio, Nico Hampe, Erik Noetzel, Bernd Hoffmann, Antonio DeSimone, Rudolf Merkel
Published in: Biophysical Journal, Issue 115/9, 2018, Page(s) 1770-1782, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2018.09.020

A Hybrid Multiscale Model for Cancer Invasion of the Extracellular Matrix

Author(s): Nikolaos Sfakianakis, Anotida Madzvamuse, Mark A. J. Chaplain
Published in: Multiscale Modeling & Simulation, Issue 18/2, 2020, Page(s) 824-850, ISSN 1540-3459
Publisher: Society for Industrial and Applied Mathematics
DOI: 10.1137/18m1189026

An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns

Author(s): Melanie Graessl, Johannes Koch, Abram Calderon, Dominic Kamps, Soumya Banerjee, Tomáš Mazel, Nina Schulze, Jana Kathrin Jungkurth, Rutuja Patwardhan, Djamschid Solouk, Nico Hampe, Bernd Hoffmann, Leif Dehmelt, Perihan Nalbant
Published in: The Journal of Cell Biology, Issue 216/12, 2017, Page(s) 4271-4285, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201706052

A note on how to develop interdisciplinary collaborations between experimentalists and theoreticians

Author(s): Anotida Madzvamuse, Sharon R. Lubkin
Published in: Interface Focus, Issue 6/5, 2016, Page(s) 20160069, ISSN 2042-8898
Publisher: Royal Society Publishing
DOI: 10.1098/rsfs.2016.0069

Effects of Plectin Depletion on Keratin Network Dynamics and Organization

Author(s): Marcin Moch, Reinhard Windoffer, Nicole Schwarz, Raphaela Pohl, Andreas Omenzetter, Uwe Schnakenberg, Fabian Herb, Kraisorn Chaisaowong, Dorit Merhof, Lena Ramms, Gloria Fabris, Bernd Hoffmann, Rudolf Merkel, Rudolf E. Leube
Published in: PLOS ONE, Issue 11/3, 2016, Page(s) e0149106, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0149106

The bulk-surface finite element method for reaction–diffusion systems on stationary volumes

Author(s): Anotida Madzvamuse, Andy H.W. Chung
Published in: Finite Elements in Analysis and Design, Issue 108, 2016, Page(s) 9-21, ISSN 0168-874X
Publisher: Elsevier BV
DOI: 10.1016/j.finel.2015.09.002

Stability analysis of reaction-diffusion models on evolving domains: The effects of cross-diffusion

Author(s): Anotida Madzvamuse, Hussaini Ndakwo, Raquel Barreira
Published in: Discrete and Continuous Dynamical Systems, Issue 36/4, 2016, Page(s) 2133-2170, ISSN 1078-0947
Publisher: Dept. of Mathematics, Southwest Missouri State University
DOI: 10.3934/dcds.2016.36.2133

A coupled bulk-surface model for cell polarisation

Author(s): D. Cusseddu, L. Edelstein-Keshet, J.A. Mackenzie, S. Portet, A. Madzvamuse
Published in: Journal of Theoretical Biology, 2018, ISSN 0022-5193
Publisher: Academic Press
DOI: 10.1016/j.jtbi.2018.09.008

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Author(s): D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Published in: Nature Communications, Issue 9/1, 2018, Page(s) Article number 1132, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03426-2

Potential impact of invasive surgical procedures on primary tumor growth and metastasis

Author(s): Maria Alieva, Jacco van Rheenen, Marike L. D. Broekman
Published in: Clinical & Experimental Metastasis, Issue 35/4, 2018, Page(s) 319-331, ISSN 0262-0898
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10585-018-9896-8

Domain-growth-induced patterning for reaction-diffusion systems with linear cross-diffusion

Author(s): Anotida Madzvamuse, Raquel Barreira
Published in: Discrete & Continuous Dynamical Systems - B, Issue 22/11, 2017, Page(s) 1-27, ISSN 1531-3492
Publisher: American Institute of Mathematical Sciences
DOI: 10.3934/dcdsb.2018163

Intracellular Motility of Intermediate Filaments

Author(s): Rudolf E. Leube, Marcin Moch, Reinhard Windoffer
Published in: Cold Spring Harbor Perspectives in Biology, Issue 9/6, 2017, Page(s) a021980, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a021980

A mathematical understanding of how cytoplasmic dynein walks on microtubules

Author(s): L. Trott, M. Hafezparast, A. Madzvamuse
Published in: Royal Society Open Science, Issue 5/8, 2018, Page(s) 171568, ISSN 2054-5703
Publisher: Royal Society
DOI: 10.1098/rsos.171568

Bayesian Parameter Identification for Turing Systems on Stationary and Evolving Domains

Author(s): Eduard Campillo-Funollet, Chandrasekhar Venkataraman, Anotida Madzvamuse
Published in: Bulletin of Mathematical Biology, 2018, Page(s) 1-24, ISSN 0092-8240
Publisher: Academic Press
DOI: 10.1007/s11538-018-0518-z

Numerical Preservation of Velocity Induced Invariant Regions for Reaction–Diffusion Systems on Evolving Surfaces

Author(s): Massimo Frittelli, Anotida Madzvamuse, Ivonne Sgura, Chandrasekhar Venkataraman
Published in: Journal of Scientific Computing, Issue 77/2, 2018, Page(s) 971-1000, ISSN 0885-7474
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10915-018-0741-7

A Model for Selection of Eyespots on Butterfly Wings

Author(s): Toshio Sekimura, Chandrasekhar Venkataraman, Anotida Madzvamuse
Published in: PLOS ONE, Issue 10/11, 2015, Page(s) e0141434, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0141434

Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function

Author(s): Nicole Schwarz, Rudolf Leube
Published in: Cells, Issue 5/3, 2016, Page(s) 30, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells5030030

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Author(s): Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen
Published in: The EMBO Journal, Issue 37/15, 2018, Page(s) e98357, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798357

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

Author(s): Arianna Fumagalli, Saskia J E Suijkerbuijk, Harry Begthel, Evelyne Beerling, Koen C Oost, Hugo J Snippert, Jacco van Rheenen, Jarno Drost
Published in: Nature Protocols, Issue 13/2, 2018, Page(s) 235-247, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/nprot.2017.137

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

Author(s): Scott Rata, Maria F. Suarez Peredo Rodriguez, Stephy Joseph, Nisha Peter, Fabio Echegaray Iturra, Fengwei Yang, Anotida Madzvamuse, Jan G. Ruppert, Kumiko Samejima, Melpomeni Platani, Monica Alvarez-Fernandez, Marcos Malumbres, William C. Earnshaw, Bela Novak, Helfrid Hochegger
Published in: Current Biology, Issue 28/23, 2018, Page(s) 3824-3832.e6, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.09.059

A Modular and Affordable Time-Lapse Imaging and Incubation System Based on 3D-Printed Parts, a Smartphone, and Off-The-Shelf Electronics

Author(s): Rodrigo Hernández Vera, Emil Schwan, Nikos Fatsis-Kavalopoulos, Johan Kreuger
Published in: PLOS ONE, Issue 11/12, 2016, Page(s) e0167583, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0167583

Analysis and Simulations of Coupled Bulk-surface Reaction-Diffusion Systems on Exponentially Evolving Volumes

Author(s): A. Madzvamuse, A. H. Chung
Published in: Mathematical Modelling of Natural Phenomena, Issue 11/5, 2016, Page(s) 4-32, ISSN 1760-6101
Publisher: EDP Sciences
DOI: 10.1051/mmnp/201611502

A computational framework for particle and whole cell tracking applied to a real biological dataset

Author(s): Feng Wei Yang, Chandrasekhar Venkataraman, Vanessa Styles, Verena Kuttenberger, Elias Horn, Zeno von Guttenberg, Anotida Madzvamuse
Published in: Journal of Biomechanics, Issue February 2016, 2016, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2016.02.008

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Author(s): Saskia J.E. Suijkerbuijk, Jacco van Rheenen
Published in: Developmental Biology, Issue 428/2, 2017, Page(s) 328-337, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2017.04.015

Domain-Dependent Stability Analysis of a Reaction–Diffusion Model on Compact Circular Geometries

Author(s): Wakil Sarfaraz, Anotida Madzvamuse
Published in: International Journal of Bifurcation and Chaos, Issue 28/08, 2018, Page(s) 1830024, ISSN 0218-1274
Publisher: World Scientific Publishing Co
DOI: 10.1142/s0218127418300240

Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes

Author(s): Laura Bornes, Reinhard Windoffer, Rudolf E Leube, Jessica Morgner, Jacco van Rheenen
Published in: Life Science Alliance, Issue 4/1, 2020, Page(s) e202000765, ISSN 2575-1077
Publisher: National Library of Medicine
DOI: 10.26508/lsa.202000765

Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus

Author(s): Marina Krause, Feng Wei Yang, Mariska te Lindert, Philipp Isermann, Jan Schepens, Ralph J. A. Maas, Chandrasekhar Venkataraman, Jan Lammerding, Anotida Madzvamuse, Wiljan Hendriks, Joost te Riet, Katarina Wolf
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1779, 2019, Page(s) 20180225, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0225

A Robust and Efficient Adaptive Multigrid Solver for the Optimal Control of Phase Field Formulations of Geometric Evolution Laws

Author(s): Feng Wei Yang, Chandrasekhar Venkataraman, Vanessa Styles, Anotida Madzvamuse
Published in: Communications in Computational Physics, Issue 21/1, 2017, Page(s) 65-92, ISSN 1815-2406
Publisher: Global Science Press
DOI: 10.4208/cicp.240715.080716a

Investigating Optimal Time Step Intervals of Imaging for Data Quality through a Novel Fully-Automated Cell Tracking Approach

Author(s): Feng Wei Yang, Lea Tomášová, Zeno v. Guttenberg, Ke Chen, Anotida Madzvamuse
Published in: Journal of Imaging, Issue 6/7, 2020, Page(s) 66, ISSN 2313-433X
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/jimaging6070066

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

Author(s): Maria Alieva, Verena Leidgens, Markus J. Riemenschneider, Christoph A. Klein, Peter Hau, Jacco van Rheenen
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 2054, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-38625-4

High Accuracy Benchmark Problems for Allen-Cahn and Cahn-Hilliard Dynamics

Author(s): Jon Matteo Church
Published in: Communications in Computational Physics, Issue 26/4, 2019, Page(s) 947-972, ISSN 1815-2406
Publisher: Global Science Press
DOI: 10.4208/cicp.oa-2019-0006

Role of Rho GTPase networks in Keratinocyte migration

Author(s): Rutuja Patwardhan
Published in: 2020
Publisher: Universität Duisburg-Essen

Advanced migration assays for studying chemotaxis of slow moving cells

Author(s): Tomášová, Lea
Published in: 2021
Publisher: Rheinische Friedrich-Wilhelms-Universität Bonn

Impact of keratin network regulation on migrating cells

Author(s): Anne PORA
Published in: 2018
Publisher: Rheinisch-Westfaelische Technische Hochschule Aachen


Author(s): Galiya Sakaeva, Dmytro Kotsur, Kritika Sahni, Georg Dreissen, Julian Mattes, Bernd Hoffmann, Rudolf Merkel
Published in: 3rd International Symposium on Mechanobiology, Issue 2017, 2017
Publisher: Mechanobiology Institute Singapore


Author(s): Kritika Sahni, Dmytro Kotsur, Georg Dreissen, Dr. Julian Mattes, Dr. Bernd Hoffmann, Prof. Dr. Rudolf Merkel, Galiya Sakaeva
Published in: 3rd International Symposium on Mechanobiology, Issue 2017, 2017
Publisher: Mechanobiology Institute Singapore

Analysis of variable-order interacting multiple model algorithms for cell tracking

Author(s): K. Lomanov, J. Martinez del Rincon, P. Miller & H. Gribben
Published in: Proceedings of the 18th Irish Machine Vision and Image Processing conference, Issue Yearly, 2016, Page(s) 35-42, ISBN 978-0-9934207-1-9
Publisher: Irish Pattern Recognition and Classification Society

Cross-diffusion in reaction-diffusion models: analysis, numerics and applications

Author(s): Anotida Madzvamuse, Raquel Barreira, Alf Gerisch
Published in: Progress in Industrial Mathematics at ECMI 2016, Issue 26, 2018, Page(s) 385-392, ISBN 978-3-319-63081-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-63082-3_61

LAP-based tracking for focal adhesions

Author(s): Katerina Lomanov, Jesus Martinez del Rincon, Paul Miller, Hugh Gribben
Published in: Irish Machine Vision and Image Processing Conference Proceedings 2018: Proceedings, Issue Yearly, 2018
Publisher: The Irish Pattern Recognition & Classification Society

An algorithm for individual intermediate filament tracking

Author(s): Dmytro Kotsur, Roman Yakobenchuk, Rudolf Leube, Reinhard Windoffer, Julian Mattes
Publisher: MICCAI Society Board

Active contour models for individual keratin filament tracking

Author(s): Dmytro Kotsur, Rudolf Leube, Reinhard Windoffer, Julian Mattes
Published in: Proceedings of the OAGM&ARW Joint Workshop: Vision, Automation and Robotics, Issue May, 2017, 2017, Page(s) 109-110, ISBN 978-3-85125-524-9
Publisher: Verlag der Technischen Universität
DOI: 10.3217/978-3-85125-524-9-19

CSI-Krebs: So findet man die passende Therapie

Author(s): Martin Rümmele
Published in: medianet Dossier - health economy, Issue 10/2018, 2018, Page(s) 4-5
Publisher: medianet Verlag GmbH

Intellectual Property Rights

Intermediate Filament Tracking (IFTracking)The software is licensed under the GNU GPL v.3 License.

Application/Publication number: https://
Date: 2018-11-01

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