Eliciting Mucosal Immunity to Tuberculosis

Información del proyecto

EMI-TB

Identificador del acuerdo de subvención: 643558

DOI 10.3030/643558

Proyecto cerrado

Fecha de la firma de la CE 26 Noviembre 2014

Fecha de inicio 1 Enero 2015

Fecha de finalización 30 Junio 2019

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total € 7 999 920,11

Aportación de la UE € 7 993 660,00

Coordinado por

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Reino Unido

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demostradores, pilotos, prototipos (2)

Publication of primary research articles in high impact journals

Research publications delivered

Public dissemination to specialised and lay audiences

Media releases and public events organised, for dissemination of research findings

Publicaciones

Artículos arbitrados (22)

Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells

Autores: Federica De Santis, Noemi Poerio, Angelo Gismondi, Valentina Nanni, Gabriele Di Marco, Roberto Nisini, Maria Cristina Thaller, Antonella Canini, Maurizio Fraziano
Publicado en: PLOS ONE, Edición 14/3, 2019, Página(s) e0213150, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0213150

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells

Autores: Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Publicado en: European Journal of Immunology, 2017, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747184

Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis

Autores: Francesco Taus, Marilina B. Santucci, Emanuela Greco, Matteo Morandi, Ivana Palucci, Sabrina Mariotti, Noemi Poerio, Roberto Nisini, Giovanni Delogu, Maurizio Fraziano
Publicado en: PLOS ONE, Edición 10/5, 2015, Página(s) e0127279, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0127279

Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance

Autores: Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 45120, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep45120

Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by BCG

Autores: Alastair Copland1, Peter Hart1, Gil R. Diogo1, Shane Harris1, Mathew Paul1, Mahavir Singh2, Simon M. Cutting3 and Rajko Reljic1*
Publicado en: Frontiers in Immunology, 2018, ISSN 1664-3224
Editor: Frontiers

Nanoparticle-Fusion protein complexes protect against Mycobacterium tuberculosis infection

Autores: Peter Hart, Alastair Copland, Gil Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew Paul, Rajko Reljic
Publicado en: Molecular Therapy, 2017, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.12.016

Vaccine development might be handled more effectively in biotech companies than in academia

Autores: Juraj Ivanyi
Publicado en: BMJ, 2018, Página(s) k758, ISSN 0959-8138
Editor: British Medical Association
DOI: 10.1136/bmj.k758

Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation

Autores: Gil R. Diogo, Adam Sparrow, Matthew J. Paul, Alastair Copland, Peter J. Hart, Szymon Stelter, Craig van Dolleweerd, Pascal M.W. Drake, Derek C. Macallan, Rajko Reljic
Publicado en: Cytokine, Edición 99, 2017, Página(s) 154-162, ISSN 1043-4666
Editor: Academic Press
DOI: 10.1016/j.cyto.2017.09.007

The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases

Autores: Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.00155

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

Autores: Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Publicado en: PLOS ONE, Edición 12/2, 2017, Página(s) e0171358, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0171358

Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance

Autores: Nadia Caccamo, Francesco Dieli
Publicado en: European Journal of Immunology, Edición 46/2, 2016, Página(s) 303-306, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546225

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity

Autores: Gina R Webster, Craig van Dolleweerd, Thais Guerra, Szymon Stelter, Sven Hofmann, Mi-Young Kim, Audrey Y-H Teh, Gil Reynolds Diogo, Alastair Copland, Mathew Paul, Peter Hart, Rajko Reljic, Julian K-C Ma
Publicado en: Plant Biotechnology Journal, 2018, ISSN 1467-7644
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pbi.12932

Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease

Autores: Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
Publicado en: PLOS ONE, Edición 13/3, 2018, Página(s) e0192664, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0192664

Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG

Autores: Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.01349

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

Autores: Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09816-4

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

Autores: Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01119

Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp

Autores: Lucille Adam, Moisés López-González, Albin Björk, Sandra Pålsson, Candice Poux, Marie Wahren-Herlenius, Carmen Fernández, Anna-Lena Spetz
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01939

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

Autores: Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers SA
DOI: 10.3389/fimmu.2018.02832

High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts

Autores: Jesús Mateos, Olivia Estévez, África González-Fernández, Luis Anibarro, Ángeles Pallarés, Rajko Reljic, José M. Gallardo, Isabel Medina, Mónica Carrera
Publicado en: Journal of Proteomics, Edición 195, 2019, Página(s) 41-52, ISSN 1874-3919
Editor: Elsevier BV
DOI: 10.1016/j.jprot.2019.01.010

Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection

Autores: Katarzyna Kuczkowska, Alastair Copland, Lise Øverland, Geir Mathiesen, Andy C. Tran, Mathew J. Paul, Vincent G. H. Eijsink, Rajko Reljic
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers SA
DOI: 10.3389/fimmu.2019.01588

Emerging Themes for the Role of Antibodies in Tuberculosis

Autores: Andy C. Tran, Mi-Young Kim, Rajko Reljic
Publicado en: Immune Network, Edición 19/4, 2019, ISSN 1598-2629
Editor: Kamji Press
DOI: 10.4110/in.2019.19.e24

Bacillus Calmette-Guérin Induces PD-L1 Expression on Antigen-Presenting Cells via Autocrine and Paracrine Interleukin-STAT3 Circuits

Autores: Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-40145-0