Eliciting Mucosal Immunity to Tuberculosis

Informacje na temat projektu

EMI-TB

Identyfikator umowy o grant: 643558

DOI

10.3030/643558

Projekt został zamknięty

Data podpisania przez KE 26 Listopada 2014

Data rozpoczęcia 1 Stycznia 2015

Data zakończenia 30 Czerwca 2019

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 7 999 920,11

Wkład UE

€ 7 993 660,00

Koordynowany przez

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Demonstrators, pilots, prototypes (2)

Publication of primary research articles in high impact journals

Research publications delivered

Public dissemination to specialised and lay audiences

Media releases and public events organised, for dissemination of research findings

Publikacje

Peer reviewed articles (22)

Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells

Autorzy: Federica De Santis, Noemi Poerio, Angelo Gismondi, Valentina Nanni, Gabriele Di Marco, Roberto Nisini, Maria Cristina Thaller, Antonella Canini, Maurizio Fraziano
Opublikowane w: PLOS ONE, Numer 14/3, 2019, Strona(/y) e0213150, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0213150

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells

Autorzy: Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Opublikowane w: European Journal of Immunology, 2017, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747184

Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis

Autorzy: Francesco Taus, Marilina B. Santucci, Emanuela Greco, Matteo Morandi, Ivana Palucci, Sabrina Mariotti, Noemi Poerio, Roberto Nisini, Giovanni Delogu, Maurizio Fraziano
Opublikowane w: PLOS ONE, Numer 10/5, 2015, Strona(/y) e0127279, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0127279

Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance

Autorzy: Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 45120, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep45120

Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by BCG

Autorzy: Alastair Copland1, Peter Hart1, Gil R. Diogo1, Shane Harris1, Mathew Paul1, Mahavir Singh2, Simon M. Cutting3 and Rajko Reljic1*
Opublikowane w: Frontiers in Immunology, 2018, ISSN 1664-3224
Wydawca: Frontiers

Nanoparticle-Fusion protein complexes protect against Mycobacterium tuberculosis infection

Autorzy: Peter Hart, Alastair Copland, Gil Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew Paul, Rajko Reljic
Opublikowane w: Molecular Therapy, 2017, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.12.016

Vaccine development might be handled more effectively in biotech companies than in academia

Autorzy: Juraj Ivanyi
Opublikowane w: BMJ, 2018, Strona(/y) k758, ISSN 0959-8138
Wydawca: British Medical Association
DOI: 10.1136/bmj.k758

Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation

Autorzy: Gil R. Diogo, Adam Sparrow, Matthew J. Paul, Alastair Copland, Peter J. Hart, Szymon Stelter, Craig van Dolleweerd, Pascal M.W. Drake, Derek C. Macallan, Rajko Reljic
Opublikowane w: Cytokine, Numer 99, 2017, Strona(/y) 154-162, ISSN 1043-4666
Wydawca: Academic Press
DOI: 10.1016/j.cyto.2017.09.007

The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases

Autorzy: Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2018.00155

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

Autorzy: Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Opublikowane w: PLOS ONE, Numer 12/2, 2017, Strona(/y) e0171358, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0171358

Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance

Autorzy: Nadia Caccamo, Francesco Dieli
Opublikowane w: European Journal of Immunology, Numer 46/2, 2016, Strona(/y) 303-306, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546225

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity

Autorzy: Gina R Webster, Craig van Dolleweerd, Thais Guerra, Szymon Stelter, Sven Hofmann, Mi-Young Kim, Audrey Y-H Teh, Gil Reynolds Diogo, Alastair Copland, Mathew Paul, Peter Hart, Rajko Reljic, Julian K-C Ma
Opublikowane w: Plant Biotechnology Journal, 2018, ISSN 1467-7644
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/pbi.12932

Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease

Autorzy: Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
Opublikowane w: PLOS ONE, Numer 13/3, 2018, Strona(/y) e0192664, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0192664

Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG

Autorzy: Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.01349

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

Autorzy: Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-09816-4

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

Autorzy: Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01119

Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp

Autorzy: Lucille Adam, Moisés López-González, Albin Björk, Sandra Pålsson, Candice Poux, Marie Wahren-Herlenius, Carmen Fernández, Anna-Lena Spetz
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01939

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

Autorzy: Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers SA
DOI: 10.3389/fimmu.2018.02832

High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts

Autorzy: Jesús Mateos, Olivia Estévez, África González-Fernández, Luis Anibarro, Ángeles Pallarés, Rajko Reljic, José M. Gallardo, Isabel Medina, Mónica Carrera
Opublikowane w: Journal of Proteomics, Numer 195, 2019, Strona(/y) 41-52, ISSN 1874-3919
Wydawca: Elsevier BV
DOI: 10.1016/j.jprot.2019.01.010

Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection

Autorzy: Katarzyna Kuczkowska, Alastair Copland, Lise Øverland, Geir Mathiesen, Andy C. Tran, Mathew J. Paul, Vincent G. H. Eijsink, Rajko Reljic
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers SA
DOI: 10.3389/fimmu.2019.01588

Emerging Themes for the Role of Antibodies in Tuberculosis

Autorzy: Andy C. Tran, Mi-Young Kim, Rajko Reljic
Opublikowane w: Immune Network, Numer 19/4, 2019, ISSN 1598-2629
Wydawca: Kamji Press
DOI: 10.4110/in.2019.19.e24

Bacillus Calmette-Guérin Induces PD-L1 Expression on Antigen-Presenting Cells via Autocrine and Paracrine Interleukin-STAT3 Circuits

Autorzy: Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-40145-0