Eliciting Mucosal Immunity to Tuberculosis

Project Information

EMI-TB

Grant agreement ID: 643558

DOI 10.3030/643558

Project closed

EC signature date 26 November 2014

Start date 1 January 2015

End date 30 June 2019

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 7 999 920,11

EU contribution € 7 993 660,00

Coordinated by

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (2)

Publication of primary research articles in high impact journals

Research publications delivered

Public dissemination to specialised and lay audiences

Media releases and public events organised, for dissemination of research findings

Publications

Peer reviewed articles (22)

Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells

Author(s): Federica De Santis, Noemi Poerio, Angelo Gismondi, Valentina Nanni, Gabriele Di Marco, Roberto Nisini, Maria Cristina Thaller, Antonella Canini, Maurizio Fraziano
Published in: PLOS ONE, Issue 14/3, 2019, Page(s) e0213150, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0213150

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells

Author(s): Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Published in: European Journal of Immunology, 2017, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747184

Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis

Author(s): Francesco Taus, Marilina B. Santucci, Emanuela Greco, Matteo Morandi, Ivana Palucci, Sabrina Mariotti, Noemi Poerio, Roberto Nisini, Giovanni Delogu, Maurizio Fraziano
Published in: PLOS ONE, Issue 10/5, 2015, Page(s) e0127279, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0127279

Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance

Author(s): Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Published in: Scientific Reports, Issue 7, 2017, Page(s) 45120, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep45120

Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by BCG

Author(s): Alastair Copland1, Peter Hart1, Gil R. Diogo1, Shane Harris1, Mathew Paul1, Mahavir Singh2, Simon M. Cutting3 and Rajko Reljic1*
Published in: Frontiers in Immunology, 2018, ISSN 1664-3224
Publisher: Frontiers

Nanoparticle-Fusion protein complexes protect against Mycobacterium tuberculosis infection

Author(s): Peter Hart, Alastair Copland, Gil Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew Paul, Rajko Reljic
Published in: Molecular Therapy, 2017, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.12.016

Vaccine development might be handled more effectively in biotech companies than in academia

Author(s): Juraj Ivanyi
Published in: BMJ, 2018, Page(s) k758, ISSN 0959-8138
Publisher: British Medical Association
DOI: 10.1136/bmj.k758

Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation

Author(s): Gil R. Diogo, Adam Sparrow, Matthew J. Paul, Alastair Copland, Peter J. Hart, Szymon Stelter, Craig van Dolleweerd, Pascal M.W. Drake, Derek C. Macallan, Rajko Reljic
Published in: Cytokine, Issue 99, 2017, Page(s) 154-162, ISSN 1043-4666
Publisher: Academic Press
DOI: 10.1016/j.cyto.2017.09.007

The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases

Author(s): Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.00155

Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

Author(s): Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Published in: PLOS ONE, Issue 12/2, 2017, Page(s) e0171358, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0171358

Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance

Author(s): Nadia Caccamo, Francesco Dieli
Published in: European Journal of Immunology, Issue 46/2, 2016, Page(s) 303-306, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546225

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity

Author(s): Gina R Webster, Craig van Dolleweerd, Thais Guerra, Szymon Stelter, Sven Hofmann, Mi-Young Kim, Audrey Y-H Teh, Gil Reynolds Diogo, Alastair Copland, Mathew Paul, Peter Hart, Rajko Reljic, Julian K-C Ma
Published in: Plant Biotechnology Journal, 2018, ISSN 1467-7644
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pbi.12932

Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease

Author(s): Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
Published in: PLOS ONE, Issue 13/3, 2018, Page(s) e0192664, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0192664

Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG

Author(s): Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.01349

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

Author(s): Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09816-4

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

Author(s): Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01119

Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp

Author(s): Lucille Adam, Moisés López-González, Albin Björk, Sandra Pålsson, Candice Poux, Marie Wahren-Herlenius, Carmen Fernández, Anna-Lena Spetz
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2018.01939

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

Author(s): Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers SA
DOI: 10.3389/fimmu.2018.02832

High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts

Author(s): Jesús Mateos, Olivia Estévez, África González-Fernández, Luis Anibarro, Ángeles Pallarés, Rajko Reljic, José M. Gallardo, Isabel Medina, Mónica Carrera
Published in: Journal of Proteomics, Issue 195, 2019, Page(s) 41-52, ISSN 1874-3919
Publisher: Elsevier BV
DOI: 10.1016/j.jprot.2019.01.010

Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection

Author(s): Katarzyna Kuczkowska, Alastair Copland, Lise Øverland, Geir Mathiesen, Andy C. Tran, Mathew J. Paul, Vincent G. H. Eijsink, Rajko Reljic
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers SA
DOI: 10.3389/fimmu.2019.01588

Emerging Themes for the Role of Antibodies in Tuberculosis

Author(s): Andy C. Tran, Mi-Young Kim, Rajko Reljic
Published in: Immune Network, Issue 19/4, 2019, ISSN 1598-2629
Publisher: Kamji Press
DOI: 10.4110/in.2019.19.e24

Bacillus Calmette-Guérin Induces PD-L1 Expression on Antigen-Presenting Cells via Autocrine and Paracrine Interleukin-STAT3 Circuits

Author(s): Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-40145-0