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Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils.

Deliverables

Summer School on advances in free radical research

The Summer School will be open to all citizens and will be organised in conjunction with other organisations e.g. the Society for Free Radical Research Europe (SFRR-E) of which Griffiths on the Executive Committee. New advances in understanding of the role of redox state in chronic disease and how to manipulate them will be a focus of this meeting. The advantages of activating and inhibiting NOX will be highlighted. Participants from each centre will participate in the summer School through poster and flash presentations.

Open workshop on inter-sectoral drug development

The goal of this workshop is to provide a forum for development of new collaborations and for maximising knowledge transfer opportunities. EU officers will be invited to gain insight into the project development and its achievement of objectives in knowledge transfer.

Winter School on cell analysis

The Winter School will be open to all citizens and will be organised in conjunction with other organisations e.g. the Biochemical Society of which Griffiths is on the Metabolism Theme Panel. The advances in specificity and sensitivity of methods for measuring changes in redox state will be highlighted. Particular attention will be paid towards validation of analytical tools in biological samples.

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Publications

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

Author(s): Markus H. Hoffmann, Helen R. Griffiths
Published in: Free Radical Biology and Medicine, 2018, ISSN 0891-5849
DOI: 10.1016/j.freeradbiomed.2018.03.016

Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils

Author(s): Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01827

NOX2 mediates quiescent handling of dead cell remnants in phagocytes

Author(s): Jonas Hahn, Maximilien Euler, Emelie Kilgus, Deborah Kienhöfer, Julia Stoof, Jasmin Knopf, Madelaine Hahn, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Andriy Mokhir, Rikard Holmdahl, Martin Herrmann, Georg Schett, Luis E. Muñoz, Markus H. Hoffmann
Published in: Redox Biology, Issue 26, 2019, Page(s) 101279, ISSN 2213-2317
DOI: 10.1016/j.redox.2019.101279

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps

Author(s): Deborah Kienhöfer, Jonas Hahn, Julia Stoof, Janka Zsófia Csepregi, Christiane Reinwald, Vilma Urbonaviciute, Caroline Johnsson, Christian Maueröder, Malgorzata J. Podolska, Mona H. Biermann, Moritz Leppkes, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Luis E. Munoz, Attila Mocsai, Martin Herrmann, Georg Schett, Rikard Holmdahl, Markus H. Hoffmann
Published in: JCI Insight, Issue 2/10, 2017, Page(s) e92920, ISSN 2379-3708
DOI: 10.1172/jci.insight.92920