Obiettivo
The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a focus in cancer. Disease identification will be based in the fast (<5 minutes), ultra-sensitive (sub-pM) and label-free detection of novel highly-specific microRNA (miRNA) biomarkers, using a small volume of whole blood (<100 μL). This POC analysis device, which will have a low cost (envisaged cost < €3000), will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.
The ultra-high sensitivity required for the direct detection of miRNA biomarkers present in the bloodstream will be achieved by using a novel sensing amplification technique. This technique is based in the use of molecular beacon capture probes with an attached high index nanoparticle, so that the hybridization events are translated into the displacement of these nanoparticles from the sensor surface. The use of this self-amplification technique avoids the use of complex PCR-based amplification methods or labelling processes, which are difficult to implement on-chip.
The cost, size and weight reduction required for deploying an affordable handheld POC device will be achieved by using a novel power-based readout scheme for photonic bandgap sensing structures where the use of expensive, bulky and heavy tuneable lasers and spectrometers is avoided.
Special attention will be paid within the SAPHELY project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.
Campo scientifico (EuroSciVoc)
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- ingegneria e tecnologiaingegneria elettrica, ingegneria elettronica, ingegneria informaticaingegneria elettronicasensoribiosensori
- ingegneria e tecnologiabiotecnologia ambientalebiorilevamento
- scienze mediche e della salutemedicina clinicaoncologia
- scienze mediche e della salutescienze della salutemedicina personalizzata
- ingegneria e tecnologiananotecnologiananomateriali
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Programma(i)
- H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme
- H2020-EU.2.1.1.6. - Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies
Argomento(i)
Invito a presentare proposte
(si apre in una nuova finestra) H2020-ICT-2014
Vedi altri progetti per questo bandoBando secondario
H2020-ICT-2014-1
Meccanismo di finanziamento
RIA -Coordinatore
46022 Valencia
Spagna