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CORDIS - Resultados de investigaciones de la UE
CORDIS

Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

metagenome sequence and annotation (se abrirá en una nueva ventana)

Publication of sequenced and annotated metagenomes obtained with already available and new bioinformatics tools. Publication of metagenome data banks.

Improved bioinformatics tools (se abrirá en una nueva ventana)

Publication of new pipelines to assist genome annotation of unknown sequences.On-line open source softwares.

patenting and industrial applications (se abrirá en una nueva ventana)

Patents and preliminary tests of newly characterized enzymes and new metabolic pathways in industrial application

reports on new biocatalists (se abrirá en una nueva ventana)

Publications on new characterized biocatalists and their potential applications

Joint publications concerning WP1-WP5 (se abrirá en una nueva ventana)

"Joint publications concerning WP1-WP5. The editor of ""Computational biology and chemistry"" (impact factor 1.7), Wentian Li, invited dr. Pietro Liò (Cambridge) to organize a special issues on this matter."

proposals for new projects (se abrirá en una nueva ventana)

New proposals for EU projects.

Web page ,Twitter and Facebook account (se abrirá en una nueva ventana)

"Publlished web pages ,Twitter and Facebook accounts. Participation to the followung workshops for dissemination: http://www3.unil.ch/wpmu/eseb2015/ http://sbg.org.br/Evolution2015/ http://www.smbe.org/ eccsb/icsb http://www.iscb.org/about-ismb masamb https://twitter.com/theosysbio/status/454249905088114688 cmsb http://cmsb2015.sciencesconf.org/ http://www.physoc.org/suggest-symposium#Physiology_2015 We would like to apply to EMBO (http://applications.embo.org/01/register.php?reg=L06Q). for the organization of a workshop. "

E. focardii genome database and identification of sequences encoding molecules of interest for industrial applications. (se abrirá en una nueva ventana)

Publication of an E. focardii genome database. Identified genomic sequences encoding molecules of interest for industrial applications

New insight on the molecular mechanisms responsible for cold-adaptation and/or environmental adaptation (se abrirá en una nueva ventana)

Publications on the characterized new insights on the molecular mechanisms responsible for cold and/or environmental adaptation. The coordinator the project has been invited to organize a special issue on Frontiers in Bioengineering and Biotechnology , that will focus on this topic.

New rules for system biology (se abrirá en una nueva ventana)

Pubblications of improved bionformatic competence and that defines new rules for system biology.

genome annotations (se abrirá en una nueva ventana)

Annotated genome to be analysed for discovering biomolecules of interest. Publications of data banks.

Characterized new metabolic pathways (se abrirá en una nueva ventana)

Characterized new metabolic pathways that may be of interest for bioremediation processes and industrial application

characterization of biocatalysts of interest (se abrirá en una nueva ventana)

characterized new biocatalysts from extreme microorganisms that may be of interest for industrial applications

Optimized biomolecules (se abrirá en una nueva ventana)

production of biomolecules with optimized properties at extreme conditions, such as improved catalytic activity, catalytic specificity, thermostability and many others.

Isolation of microbes that can survive to extreme environments for cultivation when possible that can survive to extreme environments for cultivation when possibles (se abrirá en una nueva ventana)

Isolated and cultivated microbes able to survive to extreme environments, in particular psychrophilic microbes. These microbes can be the source of new enzymes and/or metabolic pathways that can be exploited in industrial applications and for bioremediation.

trained researchers on bioinformatics (se abrirá en una nueva ventana)

Trained ESR on bioinformatics able to analyse genomic and metagenomic sequences.

optimized molecules for bioremediation (se abrirá en una nueva ventana)

Optimized molecules for bioremediation with improved degradation activity of pollutants.

Characterized new biocatalists (se abrirá en una nueva ventana)

Characterizaed biomolecules that may be involved in adaptation to cold and/or extreme environment able to produce compound at low temperatures (with saving of energy) and other extreme conditions (high salt concentration, extreme pH conditions), that may be of interest for industrial applications.

patent on optimized biomolecules (se abrirá en una nueva ventana)

patent on optimized biomolecules that can be provided for industrial applications

Patents (se abrirá en una nueva ventana)

Patent of new softwares, tools and algorithms for system biology.

Publicaciones

Bioinformatics Challenges and Potentialities in Studying Extreme Environments (se abrirá en una nueva ventana)

Autores: Claudio Angione, Pietro Liò, Sandra Pucciarelli, Basarbatu Can, Maxwell Conway, Marina Lotti, Habib Bokhari, Alessio Mancini, Ugur Sezerman, Andrea Telatin
Publicado en: Computational Intelligence Methods for Bioinformatics and Biostatistics, Edición 9874, 2016, Página(s) 205-219, ISBN 978-3-319-44331-7
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-44332-4_16

Structure of a bacterial ice binding protein with two faces of interaction with ice (se abrirá en una nueva ventana)

Autores: Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini
Publicado en: The FEBS Journal, Edición 285/9, 2018, Página(s) 1653-1666, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.14434

Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes (se abrirá en una nueva ventana)

Autores: Alessandro Pischedda, Kesava Priyan Ramasamy, Marco Mangiagalli, Federica Chiappori, Luciano Milanesi, Cristina Miceli, Sandra Pucciarelli, Marina Lotti
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-33127-1

Antibiotic activity of the antioxidant drink effective Microorganism-X (EM-X) extracts against common nosocomial pathogens: an in vitro study (se abrirá en una nueva ventana)

Autores: Alessio Mancini, Sandra Pucciarelli
Publicado en: Natural Product Research, 2018, Página(s) 1-6, ISSN 1478-6419
Editor: Taylor & Francis
DOI: 10.1080/14786419.2018.1517344

CiliateGEM: an open-project and a tool for predictions of ciliate metabolic variations and experimental condition design (se abrirá en una nueva ventana)

Autores: Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro Liò, Claudio Angione, Sandra Pucciarelli
Publicado en: BMC Bioinformatics, Edición 19/S15, 2018, Página(s) 1-11, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-018-2422-9

Enzymes and ice binding proteins from Antarctic organisms (se abrirá en una nueva ventana)

Autores: M. Lotti, S. Brocca, M. Mangiagalli, A. Pischedda, M. Orlando, S. Maione, D. De Pascale, S. Pucciarelli, M. Nardini, I. Braslavsky
Publicado en: New Biotechnology, Edición 44, 2018, Página(s) S43-S44, ISSN 1871-6784
Editor: Elsevier BV
DOI: 10.1016/j.nbt.2018.05.091

Saturn-Shaped Ice Burst Pattern and Fast Basal Binding of an Ice-Binding Protein from an Antarctic Bacterial Consortium (se abrirá en una nueva ventana)

Autores: Aleksei Kaleda, Lotem Haleva, Guy Sarusi, Tova Pinsky, Marco Mangiagalli, Maya Bar Dolev, Marina Lotti, Marco Nardini, Ido Braslavsky
Publicado en: Langmuir, 2018, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.8b01914

Mechanisms of toxic action of silver nanoparticles in the protozoan Tetrahymena thermophila : From gene expression to phenotypic events (se abrirá en una nueva ventana)

Autores: Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja Orupõld, Anne Kahru
Publicado en: Environmental Pollution, 2017, ISSN 0269-7491
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2017.03.013

Rational engineering of a cold-adapted α-amylase from the Antarctic ciliate Euplotes focardii for simultaneous improvement of thermostability and catalytic activity (se abrirá en una nueva ventana)

Autores: Guang Yang, Hua Yao, Matteo Mozzicafreddo, Patrizia Ballarini, Sandra Pucciarelli, Cristina Miceli
Publicado en: Applied and Environmental Microbiology, 2017, Página(s) AEM.00449-17, ISSN 0099-2240
Editor: American Society for Microbiology
DOI: 10.1128/AEM.00449-17

Ice-binding proteins and the ‘domain of unknown function’ 3494 family (se abrirá en una nueva ventana)

Autores: Tyler D.R. Vance, Maddalena Bayer-Giraldi, Peter L. Davies, Marco Mangiagalli
Publicado en: The FEBS Journal, 2019, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.14764

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