Risultati finali Websites, patent fillings, videos etc. (1) Website A Project website will be available for the public. The first launch will be ensured by M12 and will continuously updated up to the end of the project with main public events and information. Other (3) Workshop on “Policy Development in PM” The second open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way(possible title “Policy Development in PM”. Final Conference The final conference will be organised in order to present final project results and in particular the guidelines for the use of genome-based information and technologies (D 8.6) Seminar Personalised Medicine 2020 and Beyond The First open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way. (possible title workshop “Personalized Medicine 2020 and beyond”) Documents, reports (4) Scientific Publications Each researcher will be committed in writing articles to be submitted to peer reviewed journals. Common Guidelines on Personalised Medicine The project partners will cooperate to develop standards and guidelines for the use of genome-based information and technologies. The guidelines will target the relevant policy groups, think tanks, government institutions, international collaborations, pharmaceutical companies and SMEs.The guidelines will be presented at the final conference. Report on Seminar Personalised Medicine 2020 and Beyond Report on open workshop “Personalized Medicine 2020 and beyond” (D8.2) to make results and discussions available to wider audience. Report on open workshop “Policy Development in PM” Report on open workshop “Policy Development in PM” (D8.4) to make results and discussions available to wider audience. Pubblicazioni Peer reviewed articles (32) Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium Autori: L Giraldi, E Leoncini, R Pastorino, V Wünsch-Filho, M de Carvalho, R Lopez, G Cadoni, D Arzani, L Petrelli, K Matsuo, C Bosetti, C La Vecchia, W Garavello, J Polesel, D Serraino, L Simonato, C Canova, L Richiardi, P Boffetta, M Hashibe, Y C A Lee, S Boccia Pubblicato in: Annals of Oncology, Issue 28/11, 2017, Page(s) 2843-2851, ISSN 0923-7534 Editore: Oxford University Press DOI: 10.1093/annonc/mdx486 Familial Hypercholesterolemia: A Systematic Review of Guidelines on Genetic Testing and Patient Management Autori: Giuseppe Migliara, Valentina Baccolini, Annalisa Rosso, Elvira D’Andrea, Azzurra Massimi, Paolo Villari, Corrado De Vito Pubblicato in: Frontiers in Public Health, Issue 5, 2017, ISSN 2296-2565 Editore: r DOI: 10.3389/fpubh.2017.00252 Which Lynch syndrome screening programs could be implemented in the “real world”? A systematic review of economic evaluations Autori: Marco Di Marco, Elvira D'Andrea, Nikola Panic, Valentina Baccolini, Giuseppe Migliara, Carolina Marzuillo, Corrado De Vito, Roberta Pastorino, Stefania Boccia, Paolo Villari Pubblicato in: GENETICS in MEDICINE, 2018, ISSN 1098-3600 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/gim.2017.244 A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes Autori: Jun Liu, Jan Bert van Klinken, Sabina Semiz, Ko Willems van Dijk, Aswin Verhoeven, Thomas Hankemeier, Amy C. Harms, Eric Sijbrands, Nuala A. Sheehan, Cornelia M. van Duijn, Ayşe Demirkan Pubblicato in: Diabetes, Issue 66/11, 2017, Page(s) 2915-2926, ISSN 0012-1797 Editore: American Diabetes Association DOI: 10.2337/db17-0199 Personalized PREvention of Chronic DIseases (PRECeDI):a Marie Curie RISE project Autori: Stefania Boccia , Roberta Pastorino Pubblicato in: Epidemiology Biostatistics and Public Health - 2015, Volume 12, Number 2, 2015, ISSN 2282-0930 Editore: prex DOI: 10.2427/18993 Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies Autori: Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram, Pubblicato in: Alzheimer's & Dementia, Issue 14/6, 2018, Page(s) 707-722, ISSN 1552-5260 Editore: Elsevier BV DOI: 10.1016/j.jalz.2017.11.012 Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis Autori: Roberta Pastorino, Anna Puggina, Robert Carreras-Torres, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V. Macfarlane, Luigi Barzan, Cristina Canova, Nalin S. Thakker, David I. Conway, Ariana Znaor, Claire M. Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Ioan Nicolae Pubblicato in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-018-22626-w Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium Autori: Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia Pubblicato in: European Journal of Epidemiology, Issue 33/12, 2018, Page(s) 1205-1218, ISSN 0393-2990 Editore: Kluwer Academic Publishers DOI: 10.1007/s10654-018-0409-5 How is genetic testing evaluated? A systematic review of the literature Autori: Erica Pitini, Corrado De Vito, Carolina Marzuillo, Elvira D’Andrea, Annalisa Rosso, Antonio Federici, Emilio Di Maria, Paolo Villari Pubblicato in: European Journal of Human Genetics, Issue 26/5, 2018, Page(s) 605-615, ISSN 1018-4813 Editore: Natue Publishing Group DOI: 10.1038/s41431-018-0095-5 Systematic Review and Meta-analysis of SNPs from Genome-Wide Association Studies of Head and Neck Cancer Autori: Vladimir Vukovic, Jovana Stojanovic, Alessia Vecchioni, Roberta Pastorino, Stefania Boccia Pubblicato in: Otolaryngology–Head and Neck Surgery, Issue 159/4, 2018, Page(s) 615-624, ISSN 0194-5998 Editore: American Academy of Otolaryngology DOI: 10.1177/0194599818792262 Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review Autori: Szilvia Fiatal, Róza Ádány Pubblicato in: Frontiers in Public Health, Issue 5, 2018, ISSN 2296-2565 Editore: m DOI: 10.3389/fpubh.2017.00358 A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification Autori: Alessia Tognetto, Maria Benedetta Michelazzo, Giovanna Elisa Calabró, Brigid Unim, Marco Di Marco, Walter Ricciardi, Roberta Pastorino, Stefania Boccia Pubblicato in: Frontiers in Public Health, Issue 5, 2017, ISSN 2296-2565 Editore: m DOI: 10.3389/fpubh.2017.00243 Interim results of EUPHA network members’ s survey on Public Health Genomics Autori: A Rosso, E D'Andrea, M Di Marco, E Pitini, B Unim, V Baccolini, C De Vito, C Marzuillo, MR Vacchio, F Barnhoorn, D Zeegers, P Villari Pubblicato in: European Journal of Public Health, Issue 27/suppl_3, 2017, ISSN 1101-1262 Editore: Oxford University Press DOI: 10.1093/eurpub/ckx187.327 Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations Autori: Elvira D’Andrea, Carolina Marzuillo, Corrado De Vito, Marco Di Marco, Erica Pitini, Maria Rosaria Vacchio, Paolo Villari Pubblicato in: Genetics in Medicine, Issue 18/12, 2016, Page(s) 1171-1180, ISSN 1098-3600 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/gim.2016.29 Universal screening of Lynch syndrome is ready for implementation Autori: Marco Di Marco, Elvira D’Andrea, Paolo Villari Pubblicato in: Genetics in Medicine, 2018, ISSN 1098-3600 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/s41436-018-0027-3 Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia Autori: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari Pubblicato in: European Journal of Human Genetics, 2018, ISSN 1018-4813 Editore: Natue Publishing Group DOI: 10.1038/s41431-017-0083-1 Delivery models for predictive genetic testing: preliminary results of a systematic review Autori: B Unim, T Lagerberg, G Adamo, E Pitini, E D’Andrea, MR Vacchio, C De Vito, P Villari Pubblicato in: European Journal of Public Health, Issue 26/suppl_1, 2016, ISSN 1101-1262 Editore: Oxford University Press DOI: 10.1093/eurpub/ckw169.043 Creating a common language: defining individualized, personalized and precision prevention in public health Autori: K Bíró, V Dombrádi, A Jani, K Boruzs, M Gray Pubblicato in: Journal of Public Health, 2018, ISSN 1741-3842 Editore: Oxford University Press DOI: 10.1093/pubmed/fdy066 The Cost-effectiveness of Genetic Screening for Familial Hypercholesterolemia: a Systematic Review. Autori: 9. Rosso A, Pitini E, D'Andrea E, Massimi A, De Vito C, Marzuillo C, Villari P. Pubblicato in: Ann Ig, 2017, ISSN 1120-9135 Editore: Societa Editrice Universo DOI: 10.7416/ai.2017.2178 Metabolic profiling of intra- and extracranial carotid artery atherosclerosis Autori: Dina Vojinovic, Sven J. van der Lee, Cornelia M. van Duijn, Meike W. Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M. Arfan Ikram, Aad van der Lugt, Daniel Bos Pubblicato in: Atherosclerosis, Issue 272, 2018, Page(s) 60-65, ISSN 0021-9150 Editore: Elsevier BV DOI: 10.1016/j.atherosclerosis.2018.03.015 The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study Autori: Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn Pubblicato in: The Lancet Neurology, Issue 17/5, 2018, Page(s) 434-444, ISSN 1474-4422 Editore: The Lancet Publishing Group DOI: 10.1016/s1474-4422(18)30053-x Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts Autori: Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, P Pubblicato in: Alzheimer's & Dementia, Issue 14/6, 2018, Page(s) 723-733, ISSN 1552-5260 Editore: Elsevier BV DOI: 10.1016/j.jalz.2018.01.003 Stakeholder Views on Active Cascade Screening for Familial Hypercholesterolemia Autori: Carla van El, Valentina Baccolini, Peter Piko, Martina Cornel Pubblicato in: Healthcare, Issue 6/3, 2018, Page(s) 108, ISSN 2227-9032 Editore: r DOI: 10.3390/healthcare6030108 European survey on knowledge and attitudes of public health professionals on public health genomics: Pilot Study Autori: Annalisa Rosso; Elvira D'Andrea; Marco Di Marco; Erica Pitini; Brigid Unim; Corrado De Vito; Carolina Marzuillo; Paolo Villari Pubblicato in: Epidemiology, Biostatistics and Public Health; Vol 14, No 3 (2017), Issue 1, 2017, ISSN 2282-0930 Editore: PREX DOI: 10.2427/12531 Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study Autori: Jun Liu, Sabina Semiz, Sven J. van der Lee, Ashley van der Spek, Aswin Verhoeven, Jan B. van Klinken, Eric Sijbrands, Amy C. Harms, Thomas Hankemeier, Ko Willems van Dijk, Cornelia M. van Duijn, Ayşe Demirkan Pubblicato in: Metabolomics, Issue 13/9, 2017, ISSN 1573-3882 Editore: Springer Verlag DOI: 10.1007/s11306-017-1239-2 A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy Autori: Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs Pubblicato in: BMC Medical Genomics, Issue 11/1, 2018, ISSN 1755-8794 Editore: BioMed Central DOI: 10.1186/s12920-018-0339-9 Identification of Delivery Models for the Provision of Predictive Genetic Testing in Europe: Protocol for a Multicentre Qualitative Study and a Systematic Review of the Literature Autori: Brigid Unim, Tyra Lagerberg, Erica Pitini, Corrado De Vito, Maria Rosaria Vacchio, Giovanna Adamo, Annalisa Rosso, Elvira D’Andrea, Carolina Marzuillo, Paolo Villari Pubblicato in: Frontiers in Public Health, Issue 5, 2017, ISSN 2296-2565 Editore: r DOI: 10.3389/fpubh.2017.00223 Barriers and Facilitating Factors for Implementation of Genetic Services: A Public Health Perspective Autori: Martina C. Cornel, Carla G. van El Pubblicato in: Frontiers in Public Health, Issue 5, 2017, ISSN 2296-2565 Editore: r DOI: 10.3389/fpubh.2017.00195 Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels Autori: Adrienne Tin, Yong Li, Jennifer A. Brody, Teresa Nutile, Audrey Y. Chu, Jennifer E. Huffman, Qiong Yang, Ming-Huei Chen, Cassianne Robinson-Cohen, Aurélien Macé, Jun Liu, Ayşe Demirkan, Rossella Sorice, Sanaz Sedaghat, Melody Swen, Bing Yu, Sahar Ghasemi, Alexanda Teumer, Peter Vollenweider, Marina Ciullo, Meng Li, André G. Uitterlinden, Robert Kraaij, Najaf Amin, Jeroen van Rooij, Zoltán Kut Pubblicato in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-018-06620-4 Blood-based metabolic signatures in Alzheimer's disease Autori: Francisca A. de Leeuw, Carel F.W. Peeters, Maartje I. Kester, Amy C. Harms, Eduard A. Struys, Thomas Hankemeier, Herman W.T. van Vlijmen, Sven J. van der Lee, Cornelia M. van Duijn, Philip Scheltens, Ayşe Demirkan, Mark A. van de Wiel, Wiesje M. van der Flier, Charlotte E. Teunissen Pubblicato in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 8, 2017, Page(s) 196-207, ISSN 2352-8729 Editore: Alzheimers Dement (Amst) DOI: 10.1016/j.dadm.2017.07.006 Current state of genomic policies in healthcare among EU member states: results of a survey of chief medical officers Autori: W. Mazzucco, R. Pastorino, T. Lagerberg, M. Colotto, E. d’Andrea, C. Marotta, C. Marzuillo, P. Villari, A. Federici, W. Ricciardi, S. Boccia Pubblicato in: The European Journal of Public Health, 2017, Page(s) ckw155, ISSN 1101-1262 Editore: Oxford University Press DOI: 10.1093/eurpub/ckw155 Correction: Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia Autori: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari Pubblicato in: European Journal of Human Genetics, Issue 26/9, 2018, Page(s) 1398-1398, ISSN 1018-4813 Editore: Natue Publishing Group DOI: 10.1038/s41431-018-0186-3 Other (1) Screening Programs for Lynch Syndrome in Italy: State of the Art and Future Challenges Autori: Pastorino R, Tognetto A, Boccia S Pubblicato in: Epidemiology, Biostatistics and Public Health, 2017 Editore: PREX DOI: 10.2427/12615 È in corso la ricerca di dati su OpenAIRE... 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