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Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer

Objective

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.

Call for proposal

H2020-MSCA-RISE-2014
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 103 500

Participants (8)

UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE
France
EU contribution
€ 45 000
Address
Boulevard De La Paix 9 Villa Douce
51100 Reims
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 126 000
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
PANEPISTIMIO PATRON
Greece
EU contribution
€ 103 500
Address
University Campus Rio Patras
265 04 Rio Patras
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 45 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Greece
EU contribution
€ 45 000
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
SEREND-IP GMBH
Germany
EU contribution
€ 4 500
Address
Rostockweg 25
48147 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FIDIA FARMACEUTICI SPA
Italy
EU contribution
€ 27 000
Address
Via Ponte Della Fabbrica 3/A
35031 Abano Terme
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 67 500
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments

Partners (4)

UNIVERSIDADE FEDERAL DO RIO DE JANEIRO
Brazil
Address
Av Brigadeiro Trompowski Sn 2
21941 590 Rio De Janeiro
Activity type
Higher or Secondary Education Establishments
CAIRO UNIVERSITY
Egypt
Address
Al Orman Guiza
12613 Giza
Activity type
Higher or Secondary Education Establishments
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)
Argentina
Address
Godoy Cruz 2290
C1425FQB Buenos Aires
Activity type
Research Organisations
EWHA WOMANS UNIVERSITY
South Korea
Address
52 Ewhayeodae-gil Seodaemun-gu
120 750 Seoul
Activity type
Higher or Secondary Education Establishments