Deliverables
Presentation of a document describing methods for preprocessing and processing of spectral data.
Report on the experimental results on the proof of concept to determine GAGs composition in cancer stromal tissue.
Report on experimental results on changes in invasive behaviour of cancer cells subjected to PG/GAG manipulation.
Report on the experimental results of functional in vitro experiments after treatments of cancer cell lines stimulating or inhibiting HBP, O-GlcNAcylation and epigenetic modifications.
Report on the experimental results of the analysis of angiogenic factors in immunomodulatory cells in the context of inflammatory breast cancer.
Report on experimental results of microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancer.
Report on experimental results regarding the characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfation.
Report on the correlation of GAG structure with clinicopathological parameters, including statistical analysis.
Report on experimental results of microRNA-regulation of Syndecan-1 in clinical IBC specimens.
Report on the experimental results of flow cytometric analysis of SP and ALDH phenotype of cancer stem cells.
Report on experimental results regarding chemotherapeutic resistance of PG/GAG-manipulated cancer stem cells.
Report on the experimental results of the in vivo study on the premetastatic niche.
Report on the diagnostic value of Syndecan-1 in IBC including statistical analysis.
Report on the experimental results of chromatin immunoprecipitation experiments.
Report on the experimental results of the nanostic analysis of cancer cells.
Presentation of a standardized experimental protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media.
Experimental data report on qPCR analysis of angiogenic factors in tumors related to syndecan-1.
Report on the experimental results of spectroscopic analysis of the expression of GAGs in mice lung metastatic nodules.
Report on the experimental results of 3D cultures of cancer stem cell-enriched cultures.
Report on the experimental results of the functional impact of miRNA-dependent PG and HAS regulation.
Report on the experimental results of the spectroscopic analysis of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell lines.
Report on the experimental results of the mechanistic in vitro investigation of Syndecan-dependent transcriptional activation.
Report on the experimental results of the characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor models.
Report on experimental results of the in vitro analysis of microRNA-dependent Syndecan-1 regulation in IBC.
Presentation of a standardized Protocol (Document) for Tissue Microarray Analysis by FTIR and RAMAN spectroscopy.
Report on experimental results of signal transduction analysis in cancer stem cells.
Experimental data report on the analysis of immune cells in the tumor microenvironment.
Report on the experimental results on the role of Syndecan-1 oligomerization in FAK activation.
Report on experimental data regarding the therapeutic potential of Ascidian GAGs in malignant disease.
Report on the experimental results of the impact of PG/HA on the DNA damage response.
Report on the experimental results delivering proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophages.
Experimental data report on the analysis of hyaluronic acid-dependent angiogenesis regulators.
Report on experimental data of the impact of conventional therapeutics on the premetastatic niche.
Exytablishment of, and report on the experimental results of the in vivo model of hepatocarcinogenesis.
Experimental data report on the inhibitory effect of 4- MU in vivo.
Experimental data report on the evaluation of Evaluation of HA related enzyme expression in mouse cancerous tissues.
Experimental data report on the analysis of microvascular densitty in in vivo models.
Report on experimental results of the studies on the impact of PGs and GAGs on premature senescence of cancer cells.
Report on the experimental results of epigenetic HAS2 promoter regulation.
Report on experimental results of flow cytometric and qPCR analysis of stem cell markers.
Establishment and report on experimental data of functional in vitro assays in a novel 3D culture system.
Report on experimental results on the in vitro study of the premetastatic niche.
Report on the experimental results of changes in EMT marker expression in cancer cells subjected to PG/GAG manipulation.
Report on the experimental results of the analysis of glioblastoma cell line GAG structure.
Report of experimental results on the role of PGs in TGFbeta induced EMT.
Website reporting and dissemination on the Workshop on PGs and GAGs in metastasis organized by WWU.
Website report and dissemination on the workshop epigenetic regulation of PG and GAG expression and function organized by partner UNINSUBRIA.
Establishment of GLYCANC website and social media presence (Facebook, Research Gate).
Searching for OpenAIRE data...
Publications
Author(s): Zoi Piperigkou, Martin Götte, Achilleas D. Theocharis, Nikos K. Karamanos
Published in: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
DOI: 10.1016/j.addr.2017.10.008
Author(s): Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos, Dimitris Kletsas
Published in: Matrix Biology, 2017, ISSN 0945-053X
DOI: 10.1016/j.matbio.2017.10.004
Author(s): Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-18020-7
Author(s): Eszter Regős, Hadeer Hesham Abdelfattah, Andrea Reszegi, László Szilák, Klára Werling, Gábor Szabó, András Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy
Published in: Matrix Biology, 2018, ISSN 0945-053X
DOI: 10.1016/j.matbio.2018.02.008
Author(s): Zoi Piperigkou, Benedikt Mohr, Nikos Karamanos, Martin Götte
Published in: Cell and Tissue Research, 2016, ISSN 0302-766X
DOI: 10.1007/s00441-016-2452-4
Author(s): Martin Götte, Ilona Kovalszky
Published in: Matrix Biology, 2018, ISSN 0945-053X
DOI: 10.1016/j.matbio.2018.02.018
Author(s): Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis
Published in: Matrix Biology, 2018, ISSN 0945-053X
DOI: 10.1016/j.matbio.2018.04.007
Author(s): Daiana L. Vitale, Fiorella M. Spinelli, Daiana Del Dago, Antonella Icardi, Gianina Demarchi, Ilaria Caon, Mariana García, Marcela F. Bolontrade, Alberto Passi, Carolina Cristina, Laura Alaniz
Published in: Oncotarget, Issue 9/93, 2018, ISSN 1949-2553
DOI: 10.18632/oncotarget.26379
Author(s): Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F. Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte
Published in: PLOS ONE, Issue 10/12, 2015, Page(s) e0143993, ISSN 1932-6203
DOI: 10.1371/journal.pone.0143993
Author(s): Eszter Regős, Katalin Karászi, Andrea Reszegi, András Kiss, Zsuzsa Schaff, Kornélia Baghy, Ilona Kovalszky
Published in: Pathology & Oncology Research, 2019, ISSN 1219-4956
DOI: 10.1007/s12253-019-00617-0
Author(s): Nikolaos A. Afratis, Panagiotis Bouris, Spyros S. Skandalis, Hinke A. Multhaupt, John R. Couchman, Achilleas D. Theocharis, Nikos K. Karamanos
Published in: Scientific Reports, Issue 7, 2017, Page(s) 40138, ISSN 2045-2322
DOI: 10.1038/srep40138
Author(s): Hossam Taha Mohamed, Valérie Untereiner, Ganesh D. Sockalingum, Stéphane Brézillon
Published in: Glycoconjugate Journal, 2016, ISSN 0282-0080
DOI: 10.1007/s10719-016-9743-6
Author(s): Fiorella M. Spinelli, Daiana L. Vitale, Antonella Icardi, Ilaria Caon, Alejandra Brandone, Paula Giannoni, Virginia Saturno, Alberto Passi, Mariana García, Ina Sevic, Laura Alaniz
Published in: The FEBS Journal, 2019, ISSN 1742-464X
DOI: 10.1111/febs.14871
Author(s): Daiana Vitale, Sampath Kumar Katakam, Burkhard Greve, Bohee Jang, Eok-Soo Oh, Laura Alaniz, Martin Götte
Published in: The FEBS Journal, 2019, ISSN 1742-464X
DOI: 10.1111/febs.14967
Author(s): Zsolt Horváth, Andrea Reszegi, László Szilák, Titanilla Dankó, Ilona Kovalszky, Kornélia Baghy
Published in: Cellular Signalling, 2019, Page(s) 109354, ISSN 0898-6568
DOI: 10.1016/j.cellsig.2019.109354
Author(s): Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim
Published in: PLOS ONE, Issue 14/5, 2019, Page(s) e0217550, ISSN 1932-6203
DOI: 10.1371/journal.pone.0217550
Author(s): Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos
Published in: Matrix Biology Plus, 2019, Page(s) 100008, ISSN 2590-0285
DOI: 10.1016/j.mbplus.2019.100008
Author(s): Hossam Taha Mohamed, Valérie Untereiner, Isabelle Proult, Sherif Abdelaziz Ibrahim, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Ganesh D. Sockalingum, Stéphane Brézillon
Published in: The Analyst, Issue 143/24, 2018, Page(s) 6103-6112, ISSN 0003-2654
DOI: 10.1039/c8an01292j
Author(s): Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo
Published in: The FEBS Journal, Issue 286/15, 2019, Page(s) 2937-2949, ISSN 1742-464X
DOI: 10.1111/febs.14847
Author(s): Achilleas D. Theocharis, Dimitra Manou, Nikos K. Karamanos
Published in: The FEBS Journal, Issue 286/15, 2019, Page(s) 2830-2869, ISSN 1742-464X
DOI: 10.1111/febs.14818
Author(s): S. Brézillon, V. Untereiner, H. T. Mohamed, J. Hodin, A. Chatron-Colliet, F.-X. Maquart, G. D. Sockalingum
Published in: The Analyst, Issue 142/8, 2017, Page(s) 1333-1341, ISSN 0003-2654
DOI: 10.1039/C6AN01951J
Author(s): Evgenia Karousou, Suniti Misra, Shibnath Ghatak, Katalin Dobra, Martin Götte, Davide Vigetti, Alberto Passi, Nikos K. Karamanos, Spyros S. Skandalis
Published in: Matrix Biology, Issue 59, 2017, Page(s) 3-22, ISSN 0945-053X
DOI: 10.1016/j.matbio.2016.10.001
Author(s): Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
Published in: Molecular Cancer, Issue 16/1, 2017, Page(s) 57, ISSN 1476-4598
DOI: 10.1186/s12943-017-0621-z
Author(s): Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Published in: Matrix Biology, 2017, ISSN 0945-053X
DOI: 10.1016/j.matbio.2017.08.002
Author(s): Argyris Spyrou, Soumi Kundu, Lulu Haseeb, Di Yu, Tommie Olofsson, Keith Dredge, Edward Hammond, Uri Barash, Israel Vlodavsky, Karin Forsberg-Nilsson
Published in: Molecular Cancer Therapeutics, Issue 16/8, 2017, Page(s) 1705-1716, ISSN 1535-7163
DOI: 10.1158/1535-7163.MCT-16-0900