Development of a non-invassive breath test for early diagnosis of tropical diseases

Deliverables

Project website creation and updating

Volunteers selection, clinical evaluations and breath sampling

Publications and other dissemination of the results

- Results publication in international journals, conferences and workshops - Results dissemination in different mass-media (radio, TV, journals, You Tube, etc) - Results presentation at specialised fairs (SITEX, MolFing, JLM)

Fabrication of the nanomaterial-based devices

Nanomaterials fabrication and characterisation Nanotechnology-based devices fabrication and characterisation

Material related with formation/training and knowledge-share activities

- Lectures presented by staff members at congresses/conferences organized periodically by different project partners - Workshops for discussing project achievements - Summer/winter training courses on different subjects related with the Project - Seminars presented by seconded staff at host partners

Publications

Exhaled breath analysis for gastric cancer diagnosis in Colombian patients

Author(s): Cristhian Manuel Durán-Acevedo, Aylen Lisset Jaimes-Mogollón, Oscar Eduardo Gualdrón-Guerrero, Tesfalem Geremariam Welearegay, Julián Davíd Martinez-Marín, Juan Martín Caceres-Tarazona, Zayda Constanza Sánchez-Acevedo, Kelvin de Jesus Beleño-Saenz, Umut Cindemir, Lars Österlund, Radu Ionescu
Published in: Oncotarget, Issue 9/48, 2018, Page(s) 28805-28817, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.25331

Fluctuation-enhanced sensing with organically functionalized gold nanoparticle gas sensors targeting biomedical applications

Author(s): Łukasz Lentka, Mateusz Kotarski, Janusz Smulko, Umut Cindemir, Zareh Topalian, Claes G. Granqvist, Raul Calavia, Radu Ionescu
Published in: Talanta, Issue 160, 2016, Page(s) 9-14, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2016.06.063

Fluctuation-enhanced and conductometric gas sensing with nanocrystalline NiO thin films: A comparison

Author(s): Umut Cindemir, Maciej Trawka, Janusz Smulko, Claes-Göran Granqvist, Lars Österlund, Gunnar A. Niklasson
Published in: Sensors and Actuators B: Chemical, Issue 242, 2017, Page(s) 132-139, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2016.11.015

Development and characterization of an electrochemical biosensor for creatinine detection in human urine based on functional molecularly imprinted polymer

Author(s): A. Diouf, S. Motia, N. El Alami El Hassani, N. El Bari, B. Bouchikhi
Published in: Journal of Electroanalytical Chemistry, Issue 788, 2017, Page(s) 44-53, ISSN 1572-6657
Publisher: Elsevier BV
DOI: 10.1016/j.jelechem.2017.01.068

Voltammetric electronic tongue combined with chemometric techniques for direct identification of creatinine level in human urine

Author(s): Tarik Saidi, Mohammed Moufid, Omar Zaim, Nezha El Bari, Benachir Bouchikhi
Published in: Measurement, Issue 115, 2018, Page(s) 178-184, ISSN 0263-2241
Publisher: Elsevier BV
DOI: 10.1016/j.measurement.2017.10.044

Exhaled breath analysis using electronic nose and gas chromatography–mass spectrometry for non-invasive diagnosis of chronic kidney disease, diabetes mellitus and healthy subjects

Author(s): Tarik Saidi, Omar Zaim, Mohammed Moufid, Nezha El Bari, Radu Ionescu, Benachir Bouchikhi
Published in: Sensors and Actuators B: Chemical, Issue 257, 2018, Page(s) 178-188, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2017.10.178

Fabrication and characterisation of ligand-functionalised ultrapure monodispersed metal nanoparticle nanoassemblies employing advanced gas deposition technique

Author(s): Tesfalem Geremariam Welearegay, Umut Cindemir, Lars Österlund, Radu Ionescu
Published in: Nanotechnology, Issue 29/6, 2018, Page(s) 065603, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aa9f65

Electrochemical detection of influenza virus H9N2 based on both immunomagnetic extraction and gold catalysis using an immobilization-free screen printed carbon microelectrode

Author(s): Maher Sayhi, Oussama Ouerghi, Kamel Belgacem, Marwa Arbi, Yudum Tepeli, Abdeljalil Ghram, Ülkü Anik, Lars Österlund, Dhafer Laouini, Mohamed Fethi Diouani
Published in: Biosensors and Bioelectronics, Issue 107, 2018, Page(s) 170-177, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2018.02.018

Exhaled breath gas sensing using pristine and functionalized WO3 nanowire sensors enhanced by UV-light irradiation

Author(s): Tarik Saidi, Dariusz Palmowski, Sylwia Babicz-Kiewlicz, Tesfalem Geremariam Welearegay, Nezha El Bari, Radu Ionescu, Janusz Smulko, Benachir Bouchikhi
Published in: Sensors and Actuators B: Chemical, Issue 273, 2018, Page(s) 1719-1729, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2018.07.098

Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths

Author(s): Tesfalem Geremariam Welearegay, Mohamed Fethi Diouani, Lars Österlund, Sebastian Borys, Samira Khaled, Hanen Smadhi, Florina Ionescu, Meriam Bouchekoua, Dorsaf Aloui, Dhafer Laouini, Umut Cindemir, Radu Ionescu
Published in: The Journal of Infectious Diseases, Issue 219, 2018, Page(s) 101-109, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiy449

Non-Gaussian Resistance Fluctuations in Gold-Nanoparticle-Based Gas Sensors: An Appraisal of Different Evaluation Techniques

Author(s): Łukasz Lentka, Janusz Smulko, Mateusz Kotarski, Claes-Göran Granqvist, Radu Ionescu
Published in: Sensors, Issue 17/4, 2017, Page(s) 757, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17040757

Application of Statistical Features and Multilayer Neural Network for Automatic Diagnosis of Arrhythmia by ECG Signals

Author(s): A. Ben Slama, L. Lentka, A. Mouelhi, M.F. Diouani, M. Sayadi, J. Smulko
Published in: Metrology and Measurement Systems, Issue 25, 2018, Page(s) 87-101, ISSN 0860-8229
Publisher: Polish Academy of Sciences
DOI: 10.24425/118163

Mid-infrared thin-film diamond waveguides combined with tunable quantum cascade lasers for analyzing the secondary structure of proteins

Author(s): Ángela I. López-Lorente, Pei Wang, Markus Sieger, Ernesto Vargas Catalan, Mikael Karlsson, Fredrik Nikolajeff, Lars Österlund, Boris Mizaikoff
Published in: physica status solidi (a), Issue 213/8, 2016, Page(s) 2117-2123, ISSN 1862-6300
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/pssa.201600134

Fluctuation enhanced gas sensing with WO3-based nanoparticle gas sensors modulated by UV light at selected wavelengths

Author(s): Maciej Trawka, Janusz Smulko, Lech Hasse, Claes-Göran Granqvist, Fatima Ezahra Annanouch, Radu Ionescu
Published in: Sensors and Actuators B: Chemical, Issue 234, 2016, Page(s) 453-461, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2016.05.032

Printing Ultrasensitive Artificially Intelligent Sensors Array with a Single Self-Propelled Droplet Containing Nanoparticles

Author(s): Ekhlas Homede, Mohammad Abo-Jabal, Radu Ionescu, Hossam Haick
Published in: Advanced Functional Materials, Issue 26/35, 2016, Page(s) 6359-6370, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201602326

Online monitoring of carbon dioxide and oxygen in exhaled mouse breath via substrate-integrated hollow waveguide Fourier-transform infrared-luminescence spectroscopy

Author(s): Felicia Seichter, Erhan Tütüncü, Leila Tamina Hagemann, Josef Vogt, Ulrich Wachter, Michael Gröger, Sandra Kress, Peter Radermacher, Boris Mizaikoff
Published in: Journal of Breath Research, Issue 12/3, 2018, Page(s) 036018, ISSN 1752-7163
Publisher: Institute of Physics Publishing
DOI: 10.1088/1752-7163/aabf98

Ligand-Capped Ultrapure Metal Nanoparticle Sensors for the Detection of Cutaneous Leishmaniasis Disease in Exhaled Breath

Author(s): Tesfalem Geremariam Welearegay, Mohamed Fethi Diouani, Lars Österlund, Florina Ionescu, Kamel Belgacem, Hanen Smadhi, Samira Khaled, Abdelhamid Kidar, Umut Cindemir, Dhafer Laouini, Radu Ionescu
Published in: ACS Sensors, Issue 3/12, 2018, Page(s) 2532-2540, ISSN 2379-3694
Publisher: american chemical society publications
DOI: 10.1021/acssensors.8b00759

Development of a highly sensitive and selective molecularly imprinted electrochemical sensor for sulfaguanidine detection in honey samples

Author(s): Nadia El Alami El Hassani, Eduard Llobet, Laura-Madalina Popescu, Mihai Ghita, Benachir Bouchikhi, Nezha El Bari
Published in: Journal of Electroanalytical Chemistry, Issue 823, 2018, Page(s) 647-655, ISSN 1572-6657
Publisher: Elsevier BV
DOI: 10.1016/j.jelechem.2018.07.011

Development of a novel electrochemical sensor based on electropolymerized molecularly imprinted polymer for selective detection of sodium lauryl sulfate in environmental waters and cosmetic products

Author(s): Soukaina Motia, Ioan Albert Tudor, L. Madalina Popescu, Roxana Mioara Piticescu, Benachir Bouchikhi, Nezha El Bari
Published in: Journal of Electroanalytical Chemistry, Issue 823, 2018, Page(s) 553-562, ISSN 1572-6657
Publisher: Elsevier BV
DOI: 10.1016/j.jelechem.2018.03.069

A nonenzymatic electrochemical glucose sensor based on molecularly imprinted polymer and its application in measuring saliva glucose

Author(s): Alassane Diouf, Benachir Bouchikhi, Nezha El Bari
Published in: Materials Science and Engineering: C, Issue 98, 2019, Page(s) 1196-1209, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2019.01.001

Portable exhaled breath analyzer employing fluctuation-enhanced gas sensing method in resistive gas sensors

Author(s): A. Kwiatkowski, T. Chludziński, J. Smulko
Published in: Metrology and Measurement Systems, Issue 25, 2018, Page(s) 551–560, ISSN 0860-8229
Publisher: Polish Academy of Sciences
DOI: 10.24425/123892

Polycrystalline Diamond Thin-Film Waveguides for Mid-Infrared Evanescent Field Sensors

Author(s): Julian Haas, Ernesto Vargas Catalán, Pierre Piron, Fredrik Nikolajeff, Lars Österlund, Mikael Karlsson, Boris Mizaikoff
Published in: ACS Omega, Issue 3/6, 2018, Page(s) 6190-6198, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.8b00623

Advanced Photonic Sensors Based on Interband Cascade Lasers for Real-Time Mouse Breath Analysis

Author(s): Erhan Tütüncü, Markus Nägele, Steffen Becker, Marc Fischer, Johannes Koeth, Christian Wolf, Stefan Köstler, Volker Ribitsch, Andrea Teuber, Michael Gröger, Sandra Kress, Martin Wepler, Ulrich Wachter, Josef Vogt, Peter Radermacher, Boris Mizaikoff
Published in: ACS Sensors, Issue 3/9, 2018, Page(s) 1743-1749, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.8b00477

Infrared spectroscopy based on broadly tunable quantum cascade lasers and polycrystalline diamond waveguides

Author(s): Julian Haas, Ernesto Vargas Catalán, Pierre Piron, Mikael Karlsson, Boris Mizaikoff
Published in: The Analyst, Issue 143/21, 2018, Page(s) 5112-5119, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8an00919h

Cascade laser sensing concepts for advanced breath diagnostics

Author(s): Erhan Tütüncü, Boris Mizaikoff
Published in: Analytical and Bioanalytical Chemistry, 2018, Page(s) 1-8, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-018-1509-5

Towards enhanced optical sensor performance: SEIRA and SERS with plasmonic nanostars

Author(s): O. Bibikova, J. Haas, A. I. López-Lorente, A. Popov, M. Kinnunen, I. Meglinski, B. Mizaikoff
Published in: The Analyst, Issue 142/6, 2017, Page(s) 951-958, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6AN02596J

Nanocrystalline diamond sensor targeted for selective CRP detection: an ATR-FTIR spectroscopy study

Author(s): Per Ola Andersson, Pernilla Viberg, Pontus Forsberg, Fredrik Nikolajeff, Lars Österlund, Mikael Karlsson
Published in: Analytical and Bioanalytical Chemistry, Issue 408/14, 2016, Page(s) 3675-3680, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-016-9485-0

Towards label-free mid-infrared protein assays: in-situ formation of bare gold nanoparticles for surface enhanced infrared absorption spectroscopy of bovine serum albumin

Author(s): Ángela Inmaculada López-Lorente, Pei Wang, Boris Mizaikoff
Published in: Microchimica Acta, Issue 184/2, 2017, Page(s) 453-462, ISSN 0026-3672
Publisher: Springer Verlag
DOI: 10.1007/s00604-016-2031-0

Detection of ESAT-6 by a label free miniature immuno-electrochemical biosensor as a diagnostic tool for tuberculosis

Author(s): Mohamed Fethi Diouani, Oussama Ouerghi, Amira Refai, Kamel Belgacem, Chaker Tlili, Dhafer Laouini, Makram Essafi
Published in: Materials Science and Engineering: C, Issue 74, 2017, Page(s) 465-470, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2016.12.051

Boron-doped diamond modified with gold nanoparticles for the characterization of bovine serum albumin protein

Author(s): Ángela I. López-Lorente, Javier Izquierdo, Christine Kranz, Boris Mizaikoff
Published in: Vibrational Spectroscopy, Issue 91, 2016, Page(s) 147-156, ISSN 0924-2031
Publisher: Elsevier BV
DOI: 10.1016/j.vibspec.2016.10.010

Artificial Sensory Systems Combined with UV-Vis Spectrophotometry as a Robust Approach for VOCs Analysis of Human Urine and Exhaled Breath

Author(s): Tarik Saidi, Mohamed Moufid, Omar Zaim, Nezha El Bari, Radu Ionescu, Benachir Bouchikhi
Published in: Procedia Technology, Issue 27, 2017, Page(s) 256-257, ISSN 2212-0173
Publisher: Elsevier B.V.
DOI: 10.1016/j.protcy.2017.04.110

A Novel Modular eNose System Based on Commercial MOX Sensors to Detect Low Concentrations of VOCs for Breath Gas Analysis

Author(s): Carsten Jaeschke, Oriol Gonzalez, Johannes J. Glöckler, Leila T. Hagemann, Kaylen E. Richardson, Francesc Adrover, Marta Padilla, Jan Mitrovics, Boris Mizaikoff
Published in: Proceedings, Issue 2/13, 2018, Page(s) 993, ISSN 2504-3900
Publisher: MDPI
DOI: 10.3390/proceedings2130993

Ultrapure Organically Modified Gold Nanoparticles for Breath Analysis

Author(s): T.G. Welearegay, O.E. Gualdrón, A.L. Jaimes, J.M. Cáceres, G. Pugliese, U. Cindemir, C.M. Durán, L. Österlund, R. Ionescu
Published in: Procedia Engineering, Issue 168, 2016, Page(s) 133-136, ISSN 1877-7058
Publisher: Elsevier BV
DOI: 10.1016/j.proeng.2016.11.176

Stomach Cancer Detection through Exhaled Breath using Biomarkers Analysis

Author(s): A.L. Jaimes, C.M. Durán, O.E. Gualdrón, S.R. Ionescu
Published in: Chemical Engineering Transactions, Issue 68, 2018, Page(s) 43-48, ISSN 2283-9216
Publisher: Italian Association of Chemical Engineering
DOI: 10.3303/cet1868008

Wireless Electronic Smell System for the Detection of Diseases Through the Exhaled Breath

Author(s): C. Cuastumal Vasquez, C. Duran Acevedo
Published in: Chemical Engineering Transactions, Issue 68, 2018, Page(s) 391-396
Publisher: Italian Association of Chemical Engineering
DOI: 10.3303/cet1868066

Thermal Desorption System for Breath Samples Analysis from Colombian Patients with Gastric Cancer

Author(s): J.M. Cáceres, C.M. Durán, O.E. Gualdron
Published in: Chemical Engineering Transactions, Issue 68, 2018, Page(s) 427-432, ISSN 2283-9216
Publisher: Italian Association of Chemical Engineering
DOI: 10.3303/cet1868072

Detection of seasonal allergic rhinitis from exhaled breath VOCs using an electronic nose based on an array of chemical sensors

Author(s): T. Saidi, K. Tahri, N. El Bari, R. Ionescu, B. Bouchikhi
Published in: 2015 IEEE SENSORS, 2015, Page(s) 1-4, ISBN 978-1-4799-8203-5
Publisher: IEEE
DOI: 10.1109/icsens.2015.7370579

Artificial olfactory systems can detect unique odorant signature of cancerous volatile compounds

Author(s): R. Ionescu
Published in: Volatiles Metabolomics Analysis in Biomedical Diagnosis Applications, 2018, Page(s) 79-103, ISBN 9781-771887441
Publisher: Apple Academic Press

Diamond Waveguides for Infrared Spectroscopy and Sensing

Author(s): Á.I. López-Lorente, M. Karlsson, L. Österlund, B. Mizaikoff
Published in: Springer Series on Chemical Sensors and Biosensors (Methods and Applications), 2017
Publisher: Springer

Intellectual Property Rights

Dispositivo de olfato electrónico para el diagnóstico precoz de cáncer gástrico

Application/Publication number: NC 2017/0001745
Date: 2017-02-23
Applicant(s): UNIVERSITAT ROVIRA I VIRGILI

The innovative Integration concept by OEM solutions for portable analytical instrumentation of breath analysis

Application/Publication number: OSIM a16/23450
Date: 2018-02-15
Applicant(s): SITEX 45 SRL

Método para el diagnóstico del Dengue

Application/Publication number: NC 2018/0004119
Date: 2018-10-26
Applicant(s): UNIVERSITAT ROVIRA I VIRGILI

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