Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Autori: Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A
Pubblicato in: Autophagy, Numero 17(12), 2021, Pagina/e 1-382, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2020.1797280

Presynaptic Autophagy and the Connection With Neurotransmission

Autori: Marianna Decet, Patrik Verstreken
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2022, Pagina/e 790721, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2021.790721

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms

Autori: Julie Jacquemyn, Joyce Foroozandeh, Katlijn Vints, Jef Swerts, Patrik Verstreken, Natalia V Gounko, Sandra F Gallego, Rose Goodchild
Pubblicato in: The EMBO Journal, Numero 40(17), 2021, Pagina/e e106914, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020106914

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Autori: Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken & Hilde Van Esch
Pubblicato in: Scientific Reports, Numero 11(1), 2021, Pagina/e 4976, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-83771-3

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

Autori: Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées
Pubblicato in: eLife, Numero 9, 2020, Pagina/e e64922, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.64922

Molecule-to-Circuit Disease Mechanisms of a Synaptic SNAREopathy

Autori: Roman Praschberger, Julie Jacquemyn, Patrik Verstreken
Pubblicato in: Neuron, Numero 109(1), 2021, Pagina/e 1-3, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.12.009

Endophilin-B regulates autophagy during synapse development and neurodegeneration

Autori: Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup
Pubblicato in: Neurobiology of Disease, Numero 163, 2022, Pagina/e 105595, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2021.105595

Synaptic proteostasis in Parkinson’s disease

Autori: Eliana Nachman, Patrik Verstreken
Pubblicato in: Current Opinion in Neurobiology, Numero 72, 2021, Pagina/e 72-79, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2021.09.001

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Autori: Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa & Pierre Dourlen
Pubblicato in: Acta Neuropathologica Communications, Numero 10(1), 2022, Pagina/e 4, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-021-01285-5

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

Autori: Luis Aragão Gomes, Valerie Uytterhoeven, Diego Lopez-Sanmartin, Sandra O. Tomé, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Patrik Verstreken, Dietmar Rudolf Thal
Pubblicato in: Acta Neuropathologica, Numero 141, 2021, Pagina/e 173-192, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-020-02251-6

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autori: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Pubblicato in: Neuron, Numero 97/4, 2018, Pagina/e 823-835.e8, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

Autori: Kristofer Davie, Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aert
Pubblicato in: Cell, 2018, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2018.05.057

Reprogramming neurodegeneration in the big data era

Autori: Lujia Zhou, Patrik Verstreken
Pubblicato in: Current Opinion in Neurobiology, Numero 48, 2018, Pagina/e 167-173, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2017.12.015

p13 protects against Parkinson's disease

Autori: Jorge S Valadas, Patrik Verstreken
Pubblicato in: EMBO reports, Numero 19/3, 2018, Pagina/e e45900, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201845900

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

Autori: Jorge S. Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken
Pubblicato in: Neuron, Numero 98/6, 2018, Pagina/e 1155-1169.e6, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2018.05.022

Tau association with synaptic vesicles causes presynaptic dysfunction

Autori: Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15295, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15295

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival

Autori: J. R. Slabbaert, S. Kuenen, J. Swerts, I. Maes, V. Uytterhoeven, J. Kasprowicz, A. C. Fernandes, R. Blust, P. Verstreken
Pubblicato in: Journal of Neuroscience, Numero 36/6, 2016, Pagina/e 1914-1929, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3432-15.2016

Torsins Are Essential Regulators of Cellular Lipid Metabolism

Autori: Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild
Pubblicato in: Developmental Cell, Numero 38/3, 2016, Pagina/e 235-247, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2016.06.017

Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

Autori: Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, St
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 11710, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms11710

Loss of Bin1 Promotes the Propagation of Tau Pathology

Autori: Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars
Pubblicato in: Cell Reports, Numero 17/4, 2016, Pagina/e 931-940, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.063

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function

Autori: Baptiste Fischer, Kevin Lüthy, Jone Paesmans, Charlotte De Koninck, Ine Maes, Jef Swerts, Sabine Kuenen, Valerie Uytterhoeven, Patrik Verstreken, Wim Versées
Pubblicato in: Nature Structural & Molecular Biology, Numero 23/11, 2016, Pagina/e 965-973, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/nsmb.3297

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Autori: John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Pubblicato in: Cell Reports, Numero 17/4, 2016, Pagina/e 1071-1086, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.058

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

Autori: Sandra-Fausia Soukup, Sabine Kuenen, Roeland Vanhauwaert, Julia Manetsberger, Sergio Hernández-Díaz, Jef Swerts, Nils Schoovaerts, Sven Vilain, Natalia V. Gounko, Katlijn Vints, Ann Geens, Bart De Strooper, Patrik Verstreken
Pubblicato in: Neuron, Numero 92/4, 2016, Pagina/e 829-844, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2016.09.037

EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses

Autori: Sandra-Fausia Soukup, Patrik Verstreken
Pubblicato in: Autophagy, Numero 13/5, 2017, Pagina/e 971-972, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2017.1286440

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Autori: Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 13660, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms13660

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

Autori: Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken
Pubblicato in: The Journal of Cell Biology, Numero 216/3, 2017, Pagina/e 695-708, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201511044

Neurons eat glutamate to stay alive

Autori: Sarah-Maria Fendt, Patrik Verstreken
Pubblicato in: The Journal of Cell Biology, Numero 216/4, 2017, Pagina/e 863-865, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201702003

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Autori: Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, Patrik Verstreken
Pubblicato in: The EMBO Journal, Numero 36/10, 2017, Pagina/e 1392-1411, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201695773

Presynaptic protein homeostasis and neuronal function

Autori: Yu-Chun Wang, Elsa Lauwers, Patrik Verstreken
Pubblicato in: Current Opinion in Genetics & Development, Numero 44, 2017, Pagina/e 38-46, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2017.01.015

Autophagy in the presynaptic compartment in health and disease

Autori: Vinoy Vijayan, Patrik Verstreken
Pubblicato in: The Journal of Cell Biology, Numero 216/7, 2017, Pagina/e 1895-1906, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201611113

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Autori: Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen
Pubblicato in: Cell Reports, Numero 22/2, 2018, Pagina/e 427-440, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.12.054

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Autori: Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.35878

Hsp90 Mediates Membrane Deformation and Exosome Release

Autori: Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S. Zaiter, Shelli R. McAlpine, Natalia V. Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken
Pubblicato in: Molecular Cell, Numero 71/5, 2018, Pagina/e 689-702.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2018.07.016

Parkinson's disease: convergence on synaptic homeostasis

Autori: Sandra‐Fausia Soukup, Roeland Vanhauwaert, Patrik Verstreken
Pubblicato in: The EMBO Journal, Numero 37/18, 2018, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201898960

Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia

Autori: Ana Cascalho, Joyce Foroozandeh, Lise Hennebel, Jef Swerts, Christine Klein, Stef Rous, Beatriz Dominguez Gonzalez, Antonio Pisani, Maria Meringolo, Sandra F Gallego, Patrik Verstreken, Philip Seibler, Rose E Goodchild
Pubblicato in: Brain, Numero 143/6, 2020, Pagina/e 1746-1765, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa139

LifeTime and improving European healthcare through cell-based interceptive medicine

Autori: Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Ch
Pubblicato in: Nature, Numero 587 (7834), 2020, Pagina/e 377-386, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autori: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Pubblicato in: Neuron, Numero 109(5), 2021, Pagina/e 767-777, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

α-Synuclein and Tau: Mitochondrial Kill Switches

Autori: Ulrike Pech, Patrik Verstreken
Pubblicato in: Neuron, Numero 97/1, 2018, Pagina/e 3-4, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2017.12.024

Membrane Lipids in Presynaptic Function and Disease

Autori: Elsa Lauwers, Rose Goodchild, Patrik Verstreken
Pubblicato in: Neuron, Numero 90/1, 2016, Pagina/e 11-25, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2016.02.033

Imaging mitophagy in the fruit fly

Autori: Tom Cornelissen, Patrik Verstreken, Wim Vandenberghe
Pubblicato in: Autophagy, Numero 14/9, 2018, Pagina/e 1656-1657, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2018.1496720

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Autori: Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier
Pubblicato in: Neuropharmacology, Numero 169, 2020, Pagina/e 107554, ISSN 0028-3908
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.02.036

Autori: Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini
Pubblicato in: Brain, Numero 142/8, 2019, Pagina/e 2319-2335, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awz175

Mitochondria Re-set Epilepsy

Autori: Valerie Uytterhoeven, Natalie Kaempf, Patrik Verstreken
Pubblicato in: Neuron, Numero 102/5, 2019, Pagina/e 907-910, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2019.05.023

Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye

Autori: Elsa Lauwers, Patrik Verstreken
Pubblicato in: Clathrin-Mediated Endocytosis - Methods and Protocols, Numero 1847, 2018, Pagina/e 109-119, ISBN 978-1-4939-8717-7
Editore: Springer New York
DOI: 10.1007/978-1-4939-8719-1_9

Pubblicazioni

Condividi questa pagina

Scarica