Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Autores: Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A
Publicado en: Autophagy, Edición 17(12), 2021, Página(s) 1-382, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2020.1797280

Presynaptic Autophagy and the Connection With Neurotransmission

Autores: Marianna Decet, Patrik Verstreken
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9, 2022, Página(s) 790721, ISSN 2296-634X
Editor: Frontiers Media SA
DOI: 10.3389/fcell.2021.790721

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms

Autores: Julie Jacquemyn, Joyce Foroozandeh, Katlijn Vints, Jef Swerts, Patrik Verstreken, Natalia V Gounko, Sandra F Gallego, Rose Goodchild
Publicado en: The EMBO Journal, Edición 40(17), 2021, Página(s) e106914, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2020106914

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Autores: Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken & Hilde Van Esch
Publicado en: Scientific Reports, Edición 11(1), 2021, Página(s) 4976, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-83771-3

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

Autores: Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées
Publicado en: eLife, Edición 9, 2020, Página(s) e64922, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.64922

Molecule-to-Circuit Disease Mechanisms of a Synaptic SNAREopathy

Autores: Roman Praschberger, Julie Jacquemyn, Patrik Verstreken
Publicado en: Neuron, Edición 109(1), 2021, Página(s) 1-3, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.12.009

Endophilin-B regulates autophagy during synapse development and neurodegeneration

Autores: Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup
Publicado en: Neurobiology of Disease, Edición 163, 2022, Página(s) 105595, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2021.105595

Synaptic proteostasis in Parkinson’s disease

Autores: Eliana Nachman, Patrik Verstreken
Publicado en: Current Opinion in Neurobiology, Edición 72, 2021, Página(s) 72-79, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2021.09.001

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Autores: Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa & Pierre Dourlen
Publicado en: Acta Neuropathologica Communications, Edición 10(1), 2022, Página(s) 4, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-021-01285-5

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

Autores: Luis Aragão Gomes, Valerie Uytterhoeven, Diego Lopez-Sanmartin, Sandra O. Tomé, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Patrik Verstreken, Dietmar Rudolf Thal
Publicado en: Acta Neuropathologica, Edición 141, 2021, Página(s) 173-192, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02251-6

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autores: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Publicado en: Neuron, Edición 97/4, 2018, Página(s) 823-835.e8, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

Autores: Kristofer Davie, Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aert
Publicado en: Cell, 2018, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.05.057

Reprogramming neurodegeneration in the big data era

Autores: Lujia Zhou, Patrik Verstreken
Publicado en: Current Opinion in Neurobiology, Edición 48, 2018, Página(s) 167-173, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2017.12.015

p13 protects against Parkinson's disease

Autores: Jorge S Valadas, Patrik Verstreken
Publicado en: EMBO reports, Edición 19/3, 2018, Página(s) e45900, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201845900

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

Autores: Jorge S. Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken
Publicado en: Neuron, Edición 98/6, 2018, Página(s) 1155-1169.e6, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2018.05.022

Tau association with synaptic vesicles causes presynaptic dysfunction

Autores: Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 15295, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15295

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival

Autores: J. R. Slabbaert, S. Kuenen, J. Swerts, I. Maes, V. Uytterhoeven, J. Kasprowicz, A. C. Fernandes, R. Blust, P. Verstreken
Publicado en: Journal of Neuroscience, Edición 36/6, 2016, Página(s) 1914-1929, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3432-15.2016

Torsins Are Essential Regulators of Cellular Lipid Metabolism

Autores: Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild
Publicado en: Developmental Cell, Edición 38/3, 2016, Página(s) 235-247, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2016.06.017

Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

Autores: Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, St
Publicado en: Nature Communications, Edición 7, 2016, Página(s) 11710, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms11710

Loss of Bin1 Promotes the Propagation of Tau Pathology

Autores: Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars
Publicado en: Cell Reports, Edición 17/4, 2016, Página(s) 931-940, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.063

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function

Autores: Baptiste Fischer, Kevin Lüthy, Jone Paesmans, Charlotte De Koninck, Ine Maes, Jef Swerts, Sabine Kuenen, Valerie Uytterhoeven, Patrik Verstreken, Wim Versées
Publicado en: Nature Structural & Molecular Biology, Edición 23/11, 2016, Página(s) 965-973, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/nsmb.3297

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Autores: John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Publicado en: Cell Reports, Edición 17/4, 2016, Página(s) 1071-1086, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.058

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

Autores: Sandra-Fausia Soukup, Sabine Kuenen, Roeland Vanhauwaert, Julia Manetsberger, Sergio Hernández-Díaz, Jef Swerts, Nils Schoovaerts, Sven Vilain, Natalia V. Gounko, Katlijn Vints, Ann Geens, Bart De Strooper, Patrik Verstreken
Publicado en: Neuron, Edición 92/4, 2016, Página(s) 829-844, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2016.09.037

EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses

Autores: Sandra-Fausia Soukup, Patrik Verstreken
Publicado en: Autophagy, Edición 13/5, 2017, Página(s) 971-972, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2017.1286440

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Autores: Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 13660, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms13660

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

Autores: Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken
Publicado en: The Journal of Cell Biology, Edición 216/3, 2017, Página(s) 695-708, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201511044

Neurons eat glutamate to stay alive

Autores: Sarah-Maria Fendt, Patrik Verstreken
Publicado en: The Journal of Cell Biology, Edición 216/4, 2017, Página(s) 863-865, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201702003

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Autores: Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, Patrik Verstreken
Publicado en: The EMBO Journal, Edición 36/10, 2017, Página(s) 1392-1411, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201695773

Presynaptic protein homeostasis and neuronal function

Autores: Yu-Chun Wang, Elsa Lauwers, Patrik Verstreken
Publicado en: Current Opinion in Genetics & Development, Edición 44, 2017, Página(s) 38-46, ISSN 0959-437X
Editor: Elsevier BV
DOI: 10.1016/j.gde.2017.01.015

Autophagy in the presynaptic compartment in health and disease

Autores: Vinoy Vijayan, Patrik Verstreken
Publicado en: The Journal of Cell Biology, Edición 216/7, 2017, Página(s) 1895-1906, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201611113

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Autores: Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen
Publicado en: Cell Reports, Edición 22/2, 2018, Página(s) 427-440, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.12.054

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Autores: Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.35878

Hsp90 Mediates Membrane Deformation and Exosome Release

Autores: Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S. Zaiter, Shelli R. McAlpine, Natalia V. Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken
Publicado en: Molecular Cell, Edición 71/5, 2018, Página(s) 689-702.e9, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2018.07.016

Parkinson's disease: convergence on synaptic homeostasis

Autores: Sandra‐Fausia Soukup, Roeland Vanhauwaert, Patrik Verstreken
Publicado en: The EMBO Journal, Edición 37/18, 2018, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201898960

Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia

Autores: Ana Cascalho, Joyce Foroozandeh, Lise Hennebel, Jef Swerts, Christine Klein, Stef Rous, Beatriz Dominguez Gonzalez, Antonio Pisani, Maria Meringolo, Sandra F Gallego, Patrik Verstreken, Philip Seibler, Rose E Goodchild
Publicado en: Brain, Edición 143/6, 2020, Página(s) 1746-1765, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awaa139

LifeTime and improving European healthcare through cell-based interceptive medicine

Autores: Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Ch
Publicado en: Nature, Edición 587 (7834), 2020, Página(s) 377-386, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autores: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Publicado en: Neuron, Edición 109(5), 2021, Página(s) 767-777, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

α-Synuclein and Tau: Mitochondrial Kill Switches

Autores: Ulrike Pech, Patrik Verstreken
Publicado en: Neuron, Edición 97/1, 2018, Página(s) 3-4, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2017.12.024

Membrane Lipids in Presynaptic Function and Disease

Autores: Elsa Lauwers, Rose Goodchild, Patrik Verstreken
Publicado en: Neuron, Edición 90/1, 2016, Página(s) 11-25, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2016.02.033

Imaging mitophagy in the fruit fly

Autores: Tom Cornelissen, Patrik Verstreken, Wim Vandenberghe
Publicado en: Autophagy, Edición 14/9, 2018, Página(s) 1656-1657, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2018.1496720

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Autores: Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier
Publicado en: Neuropharmacology, Edición 169, 2020, Página(s) 107554, ISSN 0028-3908
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.02.036

Autores: Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini
Publicado en: Brain, Edición 142/8, 2019, Página(s) 2319-2335, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awz175

Mitochondria Re-set Epilepsy

Autores: Valerie Uytterhoeven, Natalie Kaempf, Patrik Verstreken
Publicado en: Neuron, Edición 102/5, 2019, Página(s) 907-910, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2019.05.023

Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye

Autores: Elsa Lauwers, Patrik Verstreken
Publicado en: Clathrin-Mediated Endocytosis - Methods and Protocols, Edición 1847, 2018, Página(s) 109-119, ISBN 978-1-4939-8717-7
Editor: Springer New York
DOI: 10.1007/978-1-4939-8719-1_9

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