Objectif I propose to research, build and evaluate Interventional X-ray and Scintigraphy Imaging (IXSI). This will provide for the first time real-time, multimodality imaging during medical interventions by combining live x-ray and live nuclear imaging simultaneously from an identical viewpoint. The hybrid x-ray/nuclear imaging device will enable surgeons and interventional radiologists to exploit the power of molecular imaging in the operating theatre and intervention room through i) live guidance using 2D imaging and ii) 3D quantitative evaluation (IXSI3D). Systems, like the successful PET/CT and SPECT/CT, have revolutionized diagnostic medical imaging; however they acquire x-ray (anatomical information) and nuclear images (molecular information) in sequence. Our new technology brings live, hybrid imaging to operations and interventions. This will have a broad and powerful impact, particularly in oncological applications, including internal radiotherapy, tumor resection and biopsies.For combined X-ray/nuclear imaging, an x-ray tube, an x-ray detector and a gamma camera with collimator are required. Our concept relies on placing these three elements in one line, thus enabling imaging of the same field-of-view. However, straight-forward combination of these elements would block the line of views. Inspired by how eyes see around the nose, I invented a gamma camera geometry that sees around the x-ray tube. I have created a prototype, and using a provisional set-up based on this novel concept (patent pending), I have demonstrated IXSI’s basic principles. This proposal describes the quantum leap in medical imaging: clinical realization of IXSI for guidance, and the development of IXSI3D that enables intra-operative quantitative evaluation. I will develop algorithms and hardware, build a mobile system and prove it’s potential in a clinical research protocol. This will be the start of a new era in image-guided intervention. Champ scientifique engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensorsnatural sciencesphysical scienceselectromagnetism and electronicssemiconductivitynatural sciencesmathematicspure mathematicsgeometryengineering and technologymedical engineeringdiagnostic imagingnatural sciencesphysical sciencestheoretical physicsparticle physicsphotons Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-CoG-2014 - ERC Consolidator Grant Appel à propositions ERC-2014-CoG Voir d’autres projets de cet appel Régime de financement ERC-COG - Consolidator Grant Institution d’accueil UNIVERSITAIR MEDISCH CENTRUM UTRECHT Contribution nette de l'UE € 1 999 000,00 Adresse HEIDELBERGLAAN 100 3584 CX Utrecht Pays-Bas Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 999 000,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSITAIR MEDISCH CENTRUM UTRECHT Pays-Bas Contribution nette de l'UE € 1 999 000,00 Adresse HEIDELBERGLAAN 100 3584 CX Utrecht Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 999 000,00