COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics

Información del proyecto

COMAL

Identificador del acuerdo de subvención: 647685

DOI

10.3030/647685

Proyecto cerrado

Fecha de la firma de la CE 3 Agosto 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 28 Febrero 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 574,00

Aportación de la UE

€ 1 999 574,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (16)

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients

Autores: D Beck, J A I Thoms, C Palu, T Herold, A Shah, J Olivier, L Boelen, Y Huang, D Chacon, A Brown, M Babic, C Hahn, M Perugini, X Zhou, B J Huntly, A Schwarzer, J-H Klusmann, W E Berdel, B Wörmann, T Büchner, W Hiddemann, S K Bohlander, L B To, H S Scott, I D Lewis, R J D'Andrea, J W H Wong, J E Pimanda
Publicado en: Leukemia, Edición 32/2, 2018, Página(s) 263-272, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.210

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

Autores: Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams
Publicado en: BMC Cancer, Edición 15/1, 2015, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-015-1586-1

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Autores: Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Ric
Publicado en: Nature, Edición 537/7621, 2016, Página(s) 544-547, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature19353

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Autores: Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S.H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M.L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J.P. Huntly
Publicado en: Blood, 2018, Página(s) blood-2017-12-820035, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2017-12-820035

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

Autores: George Giotopoulos, Louise van der Weyden, Hikari Osaki, Alistair G. Rust, Paolo Gallipoli, Eshwar Meduri, Sarah J. Horton, Wai-In Chan, Donna Foster, Rab K. Prinjha, John E. Pimanda, Daniel G. Tenen, George S. Vassiliou, Steffen Koschmieder, David J. Adams, Brian J.P. Huntly
Publicado en: The Journal of Experimental Medicine, Edición 212/10, 2015, Página(s) 1551-1569, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20141661

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Autores: K Kollmann, W Warsch, C Gonzalez-Arias, F L Nice, E Avezov, J Milburn, J Li, D Dimitropoulou, S Biddie, M Wang, E Poynton, M Colzani, M R Tijssen, S Anand, U McDermott, B Huntly, T Green
Publicado en: Leukemia, Edición 31/4, 2016, Página(s) 934-944, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.280

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies

Autores: Thomas McKerrell, Thaidy Moreno, Hannes Ponstingl, Niccolo Bolli, João M. L. Dias, German Tischler, Vincenza Colonna, Bridget Manasse, Anthony Bench, David Bloxham, Bram Herman, Danielle Fletcher, Naomi Park, Michael A. Quail, Nicla Manes, Clare Hodkinson, Joanna Baxter, Jorge Sierra, Theodora Foukaneli, Alan J. Warren, Jianxiang Chi, Paul Costeas, Roland Rad, Brian Huntly, Carolyn Grove, Zemin N
Publicado en: Blood, Edición 128/1, 2016, Página(s) e1-e9, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-11-683334

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

Autores: Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach
Publicado en: Cell Reports, Edición 16/4, 2016, Página(s) 1039-1054, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.06.046

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Autores: Konstantinos Tzelepis, Hiroko Koike-Yusa, Etienne De Braekeleer, Yilong Li, Emmanouil Metzakopian, Oliver M. Dovey, Annalisa Mupo, Vera Grinkevich, Meng Li, Milena Mazan, Malgorzata Gozdecka, Shuhei Ohnishi, Jonathan Cooper, Miten Patel, Thomas McKerrell, Bin Chen, Ana Filipa Domingues, Paolo Gallipoli, Sarah Teichmann, Hannes Ponstingl, Ultan McDermott, Julio Saez-Rodriguez, Brian J.P. Huntly
Publicado en: Cell Reports, Edición 17/4, 2016, Página(s) 1193-1205, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.079

BET inhibitor resistance emerges from leukaemia stem cells

Autores: Chun Yew Fong, Omer Gilan, Enid Y. N. Lam, Alan F. Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G. Ramsay, Steven W. Lane, Omar Abdel-Wahab, Tony Kouzarides, Ricky W. Johnstone, Sarah-Jane Dawson, Brian J. P. Huntly, Rab K. Prinjha, Anthony
Publicado en: Nature, Edición 525/7570, 2015, Página(s) 538-542, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature14888

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

Autores: Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodso
Publicado en: Nature Cell Biology, Edición 19/9, 2017, Página(s) 1093-1104, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/ncb3597

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Autores: Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J. Knights, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A. Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A. Northcott
Publicado en: Nature Genetics, Edición 50/6, 2018, Página(s) 883-894, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-018-0114-z

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Autores: Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly
Publicado en: Blood, Edición 134/24, 2019, Página(s) 2195-2208, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019001553

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

Autores: Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan, Daniel Sasca, Paolo Gallipoli, Ludovica Marando, Malgorzata Gozdecka, Ryan Asby, Olivia Sheppard, Monika Dudek, Lars Bullinger, Hartmut Döhner, Richard Dillon, Sylvie Freeman, Oliver Ottmann, Alan Burnett, Nigel Russell, Elli Papaemmanuil, Robert Hills, Peter Campbell, George S. Vassiliou, Brian J.P. Huntly
Publicado en: Journal of Experimental Medicine, Edición 216/4, 2019, Página(s) 966-981, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20181276

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Autores: Gilan, O; Lam, EYN; Becher, I; Lugo, D; Cannizzaro, E; Joberty, G; Ward, A; Wiese, M; Fong, CY; Ftouni, S; Tyler, D; Stanley, K; MacPherson, L; Weng, C-F; Chan, Y-C; Ghisi, M; Smil, D; Carpenter, C; Brown, P; Garton, N; Blewitt, ME; Bannister, Andrew; Kouzarides, Tony; Huntly, Brian; Johnstone, RW; Drewes, G; Dawson, S-J; Arrowsmith, CH; Grandi, P; Prinjha, RK; Dawson, MA
Publicado en: Nature Structural & Molecular Biology, Edición 5, 2016, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.17863/cam.44304

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Autores: Christopher A.G. Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila, Elizabeth J. Soilleux, George Giotopoulos, Noushin Farnoud, Alice Giustacchini, Neil Ashley, Joana Carrelha, Lauren Jamieson, Deborah Atkinson, Tiphaine Bouriez-Jones, Rab K. Prinjha, Thomas A. Milne, David T. Teachey, Elli Papaemmanuil, Brian J.P. Huntly, Sten Eirik W. Jacobsen, Adam J. Mead
Publicado en: Cancer Cell, Edición 33/2, 2018, Página(s) 274-291.e8, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2018.01.006