COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics

Informazioni relative al progetto

COMAL

ID dell’accordo di sovvenzione: 647685

DOI 10.3030/647685

Progetto chiuso

Data della firma CE 3 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 28 Febbraio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 574,00

Contributo UE € 1 999 574,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Pubblicazioni

Peer reviewed articles (16)

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients

Autori: D Beck, J A I Thoms, C Palu, T Herold, A Shah, J Olivier, L Boelen, Y Huang, D Chacon, A Brown, M Babic, C Hahn, M Perugini, X Zhou, B J Huntly, A Schwarzer, J-H Klusmann, W E Berdel, B Wörmann, T Büchner, W Hiddemann, S K Bohlander, L B To, H S Scott, I D Lewis, R J D'Andrea, J W H Wong, J E Pimanda
Pubblicato in: Leukemia, Numero 32/2, 2018, Pagina/e 263-272, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.210

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

Autori: Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams
Pubblicato in: BMC Cancer, Numero 15/1, 2015, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-015-1586-1

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Autori: Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Ric
Pubblicato in: Nature, Numero 537/7621, 2016, Pagina/e 544-547, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature19353

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Autori: Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S.H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M.L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J.P. Huntly
Pubblicato in: Blood, 2018, Pagina/e blood-2017-12-820035, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2017-12-820035

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

Autori: George Giotopoulos, Louise van der Weyden, Hikari Osaki, Alistair G. Rust, Paolo Gallipoli, Eshwar Meduri, Sarah J. Horton, Wai-In Chan, Donna Foster, Rab K. Prinjha, John E. Pimanda, Daniel G. Tenen, George S. Vassiliou, Steffen Koschmieder, David J. Adams, Brian J.P. Huntly
Pubblicato in: The Journal of Experimental Medicine, Numero 212/10, 2015, Pagina/e 1551-1569, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20141661

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Autori: K Kollmann, W Warsch, C Gonzalez-Arias, F L Nice, E Avezov, J Milburn, J Li, D Dimitropoulou, S Biddie, M Wang, E Poynton, M Colzani, M R Tijssen, S Anand, U McDermott, B Huntly, T Green
Pubblicato in: Leukemia, Numero 31/4, 2016, Pagina/e 934-944, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.280

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies

Autori: Thomas McKerrell, Thaidy Moreno, Hannes Ponstingl, Niccolo Bolli, João M. L. Dias, German Tischler, Vincenza Colonna, Bridget Manasse, Anthony Bench, David Bloxham, Bram Herman, Danielle Fletcher, Naomi Park, Michael A. Quail, Nicla Manes, Clare Hodkinson, Joanna Baxter, Jorge Sierra, Theodora Foukaneli, Alan J. Warren, Jianxiang Chi, Paul Costeas, Roland Rad, Brian Huntly, Carolyn Grove, Zemin N
Pubblicato in: Blood, Numero 128/1, 2016, Pagina/e e1-e9, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2015-11-683334

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

Autori: Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach
Pubblicato in: Cell Reports, Numero 16/4, 2016, Pagina/e 1039-1054, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.06.046

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Autori: Konstantinos Tzelepis, Hiroko Koike-Yusa, Etienne De Braekeleer, Yilong Li, Emmanouil Metzakopian, Oliver M. Dovey, Annalisa Mupo, Vera Grinkevich, Meng Li, Milena Mazan, Malgorzata Gozdecka, Shuhei Ohnishi, Jonathan Cooper, Miten Patel, Thomas McKerrell, Bin Chen, Ana Filipa Domingues, Paolo Gallipoli, Sarah Teichmann, Hannes Ponstingl, Ultan McDermott, Julio Saez-Rodriguez, Brian J.P. Huntly
Pubblicato in: Cell Reports, Numero 17/4, 2016, Pagina/e 1193-1205, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.079

BET inhibitor resistance emerges from leukaemia stem cells

Autori: Chun Yew Fong, Omer Gilan, Enid Y. N. Lam, Alan F. Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G. Ramsay, Steven W. Lane, Omar Abdel-Wahab, Tony Kouzarides, Ricky W. Johnstone, Sarah-Jane Dawson, Brian J. P. Huntly, Rab K. Prinjha, Anthony
Pubblicato in: Nature, Numero 525/7570, 2015, Pagina/e 538-542, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature14888

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

Autori: Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodso
Pubblicato in: Nature Cell Biology, Numero 19/9, 2017, Pagina/e 1093-1104, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/ncb3597

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Autori: Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J. Knights, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A. Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A. Northcott
Pubblicato in: Nature Genetics, Numero 50/6, 2018, Pagina/e 883-894, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0114-z

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Autori: Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly
Pubblicato in: Blood, Numero 134/24, 2019, Pagina/e 2195-2208, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019001553

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

Autori: Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan, Daniel Sasca, Paolo Gallipoli, Ludovica Marando, Malgorzata Gozdecka, Ryan Asby, Olivia Sheppard, Monika Dudek, Lars Bullinger, Hartmut Döhner, Richard Dillon, Sylvie Freeman, Oliver Ottmann, Alan Burnett, Nigel Russell, Elli Papaemmanuil, Robert Hills, Peter Campbell, George S. Vassiliou, Brian J.P. Huntly
Pubblicato in: Journal of Experimental Medicine, Numero 216/4, 2019, Pagina/e 966-981, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20181276

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Autori: Gilan, O; Lam, EYN; Becher, I; Lugo, D; Cannizzaro, E; Joberty, G; Ward, A; Wiese, M; Fong, CY; Ftouni, S; Tyler, D; Stanley, K; MacPherson, L; Weng, C-F; Chan, Y-C; Ghisi, M; Smil, D; Carpenter, C; Brown, P; Garton, N; Blewitt, ME; Bannister, Andrew; Kouzarides, Tony; Huntly, Brian; Johnstone, RW; Drewes, G; Dawson, S-J; Arrowsmith, CH; Grandi, P; Prinjha, RK; Dawson, MA
Pubblicato in: Nature Structural & Molecular Biology, Numero 5, 2016, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.17863/cam.44304

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Autori: Christopher A.G. Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila, Elizabeth J. Soilleux, George Giotopoulos, Noushin Farnoud, Alice Giustacchini, Neil Ashley, Joana Carrelha, Lauren Jamieson, Deborah Atkinson, Tiphaine Bouriez-Jones, Rab K. Prinjha, Thomas A. Milne, David T. Teachey, Elli Papaemmanuil, Brian J.P. Huntly, Sten Eirik W. Jacobsen, Adam J. Mead
Pubblicato in: Cancer Cell, Numero 33/2, 2018, Pagina/e 274-291.e8, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2018.01.006