Structural and mechanistic insights into RING E3-mediated ubiquitination

Publicaciones

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

Autores: Mads Gabrielsen, Lori Buetow, Mark A. Nakasone, Syed Feroj Ahmed, Gary J. Sibbet, Brian O. Smith, Wei Zhang, Sachdev S. Sidhu, Danny T. Huang
Publicado en: Molecular Cell, Edición 68/2, 2017, Página(s) 456-470.e10, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2017.09.027

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

Autores: Koji Nomura, Marta Klejnot, Dominika Kowalczyk, Andreas K Hock, Gary J Sibbet, Karen H Vousden, Danny T Huang
Publicado en: Nature Structural & Molecular Biology, Edición 24/7, 2017, Página(s) 578-587, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/nsmb.3414

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones

Autores: Gabriele Marcianò, Stefano Da Vela, Giancarlo Tria, Dmitri I. Svergun, Olwyn Byron, Danny T. Huang
Publicado en: Journal of Biological Chemistry, 2018, Página(s) jbc.RA117.000994, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000994

Ubiquitination Accomplished: E1 and E2 Enzymes Were Not Necessary

Autores: Mark A. Nakasone, Danny T. Huang
Publicado en: Molecular Cell, Edición 62/6, 2016, Página(s) 807-809, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2016.06.001

Structure of the human histone chaperone FACT Spt16 N-terminal domain

Autores: G. Marcianò, D. T. Huang
Publicado en: Acta Crystallographica Section F Structural Biology Communications, Edición 72/2, 2016, Página(s) 121-128, ISSN 2053-230X
Editor: John Wiley and Sons Ltd
DOI: 10.1107/S2053230X15024565

Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

Autores: Lori Buetow, Giancarlo Tria, Syed Feroj Ahmed, Andreas Hock, Hao Dou, Gary J. Sibbet, Dmitri I. Svergun, Danny T. Huang
Publicado en: BMC Biology, Edición 14/1, 2016, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-016-0298-6

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Autores: Lori Buetow, Danny T. Huang
Publicado en: Nature Reviews Molecular Cell Biology, Edición 17/10, 2016, Página(s) 626-642, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/nrm.2016.91

Identification and characterization of mutations in ubiquitin required for non-covalent dimer formation

Autores: Mads Gabrielsen, Lori Buetow, Dominika Kowalczyk, Wei Zhang, Sachdev S.Sidhu and Danny T.Huang
Publicado en: Structure, Edición 27/9, 2019, Página(s) 1452-1459.e4, ISSN 0969-2126
Editor: Cell Press
DOI: 10.1016/j.str.2019.06.008

Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex

Autores: Amrita Patel, Gary J. Sibbet, Danny T. Huang
Publicado en: Journal of Biological Chemistry, Edición 294/4, 2019, Página(s) 1240-1249, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.006045

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Autores: Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15783-y

Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays

Autores: Lori Buetow, Mads Gabrielsen, Danny T. Huang
Publicado en: The Ubiquitin Proteasome System - Methods and Protocols, Edición 1844, 2018, Página(s) 19-31, ISBN 978-1-4939-8705-4
Editor: Springer New York
DOI: 10.1007/978-1-4939-8706-1_2

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