Structural and mechanistic insights into RING E3-mediated ubiquitination

Publikacje

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

Autorzy: Mads Gabrielsen, Lori Buetow, Mark A. Nakasone, Syed Feroj Ahmed, Gary J. Sibbet, Brian O. Smith, Wei Zhang, Sachdev S. Sidhu, Danny T. Huang
Opublikowane w: Molecular Cell, Numer 68/2, 2017, Strona(/y) 456-470.e10, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2017.09.027

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

Autorzy: Koji Nomura, Marta Klejnot, Dominika Kowalczyk, Andreas K Hock, Gary J Sibbet, Karen H Vousden, Danny T Huang
Opublikowane w: Nature Structural & Molecular Biology, Numer 24/7, 2017, Strona(/y) 578-587, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/nsmb.3414

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones

Autorzy: Gabriele Marcianò, Stefano Da Vela, Giancarlo Tria, Dmitri I. Svergun, Olwyn Byron, Danny T. Huang
Opublikowane w: Journal of Biological Chemistry, 2018, Strona(/y) jbc.RA117.000994, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000994

Ubiquitination Accomplished: E1 and E2 Enzymes Were Not Necessary

Autorzy: Mark A. Nakasone, Danny T. Huang
Opublikowane w: Molecular Cell, Numer 62/6, 2016, Strona(/y) 807-809, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2016.06.001

Structure of the human histone chaperone FACT Spt16 N-terminal domain

Autorzy: G. Marcianò, D. T. Huang
Opublikowane w: Acta Crystallographica Section F Structural Biology Communications, Numer 72/2, 2016, Strona(/y) 121-128, ISSN 2053-230X
Wydawca: John Wiley and Sons Ltd
DOI: 10.1107/S2053230X15024565

Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

Autorzy: Lori Buetow, Giancarlo Tria, Syed Feroj Ahmed, Andreas Hock, Hao Dou, Gary J. Sibbet, Dmitri I. Svergun, Danny T. Huang
Opublikowane w: BMC Biology, Numer 14/1, 2016, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-016-0298-6

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Autorzy: Lori Buetow, Danny T. Huang
Opublikowane w: Nature Reviews Molecular Cell Biology, Numer 17/10, 2016, Strona(/y) 626-642, ISSN 1471-0072
Wydawca: Nature Publishing Group
DOI: 10.1038/nrm.2016.91

Identification and characterization of mutations in ubiquitin required for non-covalent dimer formation

Autorzy: Mads Gabrielsen, Lori Buetow, Dominika Kowalczyk, Wei Zhang, Sachdev S.Sidhu and Danny T.Huang
Opublikowane w: Structure, Numer 27/9, 2019, Strona(/y) 1452-1459.e4, ISSN 0969-2126
Wydawca: Cell Press
DOI: 10.1016/j.str.2019.06.008

Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex

Autorzy: Amrita Patel, Gary J. Sibbet, Danny T. Huang
Opublikowane w: Journal of Biological Chemistry, Numer 294/4, 2019, Strona(/y) 1240-1249, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.006045

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Autorzy: Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-15783-y

Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays

Autorzy: Lori Buetow, Mads Gabrielsen, Danny T. Huang
Opublikowane w: The Ubiquitin Proteasome System - Methods and Protocols, Numer 1844, 2018, Strona(/y) 19-31, ISBN 978-1-4939-8705-4
Wydawca: Springer New York
DOI: 10.1007/978-1-4939-8706-1_2

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