GENEtic DiSsection of Innate Immune Sensing and Signalling

Publicaciones

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

Autores: Sarah Kim-Hellmuth, Matthias Bechheim, Benno Pütz, Pejman Mohammadi, Yohann Nédélec, Nicholas Giangreco, Jessica Becker, Vera Kaiser, Nadine Fricker, Esther Beier, Peter Boor, Stephane E. Castel, Markus M. Nöthen, Luis B. Barreiro, Joseph K. Pickrell, Bertram Müller-Myhsok, Tuuli Lappalainen, Johannes Schumacher, Veit Hornung
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-00366-1

Alternative inflammasome activation enables IL-1β release from living cells

Autores: Moritz M Gaidt, Veit Hornung
Publicado en: Current Opinion in Immunology, Edición 44, 2017, Página(s) 7-13, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2016.10.007

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Autores: Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O’Duill, Jonathan L. Schmid-Burgk, Florian Hoss, Raymund Buhmann, Georg Wittmann, Eicke Latz, Marion Subklewe, Veit Hornung
Publicado en: Cell, Edición 171/5, 2017, Página(s) 1110-1124.e18, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2017.09.039

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

Autores: Jonathan L. Schmid-Burgk, Klara Höning, Thomas S. Ebert, Veit Hornung
Publicado en: Nature Communications, Edición 7, 2016, Página(s) 12338, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms12338

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Autores: Jonathan L. Schmid-Burgk, Dhruv Chauhan, Tobias Schmidt, Thomas S. Ebert, Julia Reinhardt, Elmar Endl, Veit Hornung
Publicado en: Journal of Biological Chemistry, Edición 291/1, 2016, Página(s) 103-109, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.C115.700492

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Autores: Søren R. Paludan, Line S. Reinert, Veit Hornung
Publicado en: Nature Reviews Immunology, Edición 19/3, 2019, Página(s) 141-153, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-018-0117-0

Molecular mechanisms and cellular functions of cGAS–STING signalling

Autores: Karl-Peter Hopfner, Veit Hornung
Publicado en: Nature Reviews Molecular Cell Biology, 2020, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-020-0244-x

TLR8 Is a Sensor of RNase T2 Degradation Products

Autores: Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Publicado en: Cell, Edición 179/6, 2019, Página(s) 1264-1275.e13, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.11.001

C-tag TNF: a reporter system to study TNF shedding

Autores: Francesca Pinci, Moritz M Gaidt, Christophe Jung, Gunnar Kuut, Margaret A Jackson, Stefan Bauernfried, Veit Hornung
Publicado en: Journal of Biological Chemistry, 2020, Página(s) jbc.RA120.015248, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015248

Human NLRP1 is a sensor for double-stranded RNA

Autores: Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Publicado en: Science, 2020, Página(s) eabd0811, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811

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