GENEtic DiSsection of Innate Immune Sensing and Signalling

Informazioni relative al progetto

GENESIS

ID dell’accordo di sovvenzione: 647858

DOI 10.3030/647858

Progetto chiuso

Data della firma CE 11 Settembre 2015

Data di avvio 1 Ottobre 2015

Data di completamento 30 Settembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 970 000,00

Contributo UE € 1 970 000,00

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Pubblicazioni

Peer reviewed articles (10)

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

Autori: Sarah Kim-Hellmuth, Matthias Bechheim, Benno Pütz, Pejman Mohammadi, Yohann Nédélec, Nicholas Giangreco, Jessica Becker, Vera Kaiser, Nadine Fricker, Esther Beier, Peter Boor, Stephane E. Castel, Markus M. Nöthen, Luis B. Barreiro, Joseph K. Pickrell, Bertram Müller-Myhsok, Tuuli Lappalainen, Johannes Schumacher, Veit Hornung
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00366-1

Alternative inflammasome activation enables IL-1β release from living cells

Autori: Moritz M Gaidt, Veit Hornung
Pubblicato in: Current Opinion in Immunology, Numero 44, 2017, Pagina/e 7-13, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2016.10.007

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Autori: Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O’Duill, Jonathan L. Schmid-Burgk, Florian Hoss, Raymund Buhmann, Georg Wittmann, Eicke Latz, Marion Subklewe, Veit Hornung
Pubblicato in: Cell, Numero 171/5, 2017, Pagina/e 1110-1124.e18, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.09.039

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

Autori: Jonathan L. Schmid-Burgk, Klara Höning, Thomas S. Ebert, Veit Hornung
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 12338, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms12338

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Autori: Jonathan L. Schmid-Burgk, Dhruv Chauhan, Tobias Schmidt, Thomas S. Ebert, Julia Reinhardt, Elmar Endl, Veit Hornung
Pubblicato in: Journal of Biological Chemistry, Numero 291/1, 2016, Pagina/e 103-109, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.C115.700492

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Autori: Søren R. Paludan, Line S. Reinert, Veit Hornung
Pubblicato in: Nature Reviews Immunology, Numero 19/3, 2019, Pagina/e 141-153, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-018-0117-0

Molecular mechanisms and cellular functions of cGAS–STING signalling

Autori: Karl-Peter Hopfner, Veit Hornung
Pubblicato in: Nature Reviews Molecular Cell Biology, 2020, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-020-0244-x

TLR8 Is a Sensor of RNase T2 Degradation Products

Autori: Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Pubblicato in: Cell, Numero 179/6, 2019, Pagina/e 1264-1275.e13, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.11.001

C-tag TNF: a reporter system to study TNF shedding

Autori: Francesca Pinci, Moritz M Gaidt, Christophe Jung, Gunnar Kuut, Margaret A Jackson, Stefan Bauernfried, Veit Hornung
Pubblicato in: Journal of Biological Chemistry, 2020, Pagina/e jbc.RA120.015248, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015248

Human NLRP1 is a sensor for double-stranded RNA

Autori: Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Pubblicato in: Science, 2020, Pagina/e eabd0811, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811