Structure and Dynamics of Low-Complexity Regions in Proteins: The Huntingtin Case

Project Information

chemREPEAT

Grant agreement ID: 648030

DOI 10.3030/648030

Project closed

EC signature date 28 August 2015

Start date 1 September 2015

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 844,00

EU contribution € 1 999 844,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (12)

Evidence of the Reduced Abundance of Proline cis Conformation in Protein Poly Proline Tracts

Author(s): Annika Urbanek; Matija Popovic; Carlos A. Elena-Real; Anna Morató; Alejandro Estaña; Aurélie Fournet; Frédéric Allemand; Ana M. Gil; Carlos Cativiela; Juan Cortés; Ana I. Jiménez; Nathalie Sibille; Pau Bernadó
Published in: Journal of the American Chemical Society, Issue 142, 2020, Page(s) 7976, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c02263

Site-Specific Isotopic Labeling (SSIL): Access to High-Resolution Structural and Dynamic Information in Low-Complexity Proteins.

Author(s): Urbanek, Annika; Elena‐Real, Carlos A.; Popovic, Matija; Morató, Anna; Fournet, Aurélie; Allemand, Frédéric; Delbecq, Stephane; Sibille, Nathalie; Bernadó, Pau
Published in: ChemBioChem, Issue 5, 2020, Page(s) 769-775, ISSN 1439-7633
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cbic.201900583

Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database

Author(s): Alejandro Estaña, Nathalie Sibille, Elise Delaforge, Marc Vaisset, Juan Cortés, Pau Bernadó
Published in: Structure, Issue 27, 2019, Page(s) 381-391, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2018.10.016

Disentangling the complexity of low complexity proteins

Author(s): Pablo Mier, Lisanna Paladin, Stella Tamana, Sophia Petrosian, Borbála Hajdu-Soltész, Annika Urbanek, Aleksandra Gruca, Dariusz Plewczynski, Marcin Grynberg, Pau Bernadó, Zoltán Gáspári, Christos A Ouzounis, Vasilis J Promponas, Andrey V Kajava, John M Hancock, Silvio C E Tosatto, Zsuzsanna Dosztanyi, Miguel A Andrade-Navarro
Published in: Briefings in Bioinformatics, Issue 21, 2020, Page(s) 458-472, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbz007

The importance of definitions in the study of polyQ regions: A tale of thresholds, impurities and sequence context.

Author(s): Pablo Mier; Carlos A. Elena-Real; Annika Urbanek; Pau Bernadó; Miguel A. Andrade-Navarro
Published in: Computational and Structural Biotechnology Journal, Issue 18, 2020, Page(s) 306-313, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2020.01.012

Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins

Author(s): Annika Urbanek, Matija Popovic, Anna Morató, Alejandro Estaña, Carlos A Elena-Real, Pablo Mier, Aurélie Fournet, Frédéric Allemand, Stephane Delbecq, Miguel A Andrade-Navarro, Juan Cortés, Nathalie Sibille, Pau Bernadó
Published in: Structure, Issue 28, 2020, Page(s) 733-746, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2020.04.008

Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins

Author(s): Anna Morató, Carlos A Elena-Real, Matija Popovic, Aurélie Fournet, Karen Zhang, Frédéric Allemand, Nathalie Sibille, Annika Urbanek, Pau Bernadó
Published in: Biomolecules, Issue 10, 2020, Page(s) 1458, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10101458

Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm

Author(s): Estaña, Alejandro; Ghallab, Malik; Bernadó, Pau; Cortés, Juan
Published in: Molecules, Issue 24, 2019, Page(s) 1150, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24061150

Predicting Secondary Structure Propensities in IDPs Using Simple Statistics from Three-Residue Fragments

Author(s): Alejandro Estaña, Amélie Barozet, Assia Mouhand, Marc Vaisset, Christophe Zanon, Pierre Fauret, Nathalie Sibille, Pau Bernadó, Juan Cortés
Published in: Journal of Molecuar Biology, Issue 432, 2020, Page(s) 5447-5459, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2020.07.026

A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats

Author(s): Annika Urbanek, Anna Morató, Frédéric Allemand, Elise Delaforge, Aurélie Fournet, Matija Popovic, Stephane Delbecq, Nathalie Sibille, Pau Bernadó
Published in: Angewandte Chemie International Edition, Issue 57/14, 2018, Page(s) 3598-3601, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711530

Hybrid parallelization of a multi-tree path search algorithm: Application to highly-flexible biomolecules

Author(s): Alejandro Estaña, Kevin Molloy, Marc Vaisset, Nathalie Sibille, Thierry Siméon, Pau Bernadó, Juan Cortés
Published in: Parallel Computing, Issue 77, 2018, Page(s) 84-100, ISSN 0167-8191
Publisher: Elsevier BV
DOI: 10.1016/j.parco.2018.06.005

Small-angle scattering studies of intrinsically disordered proteins and their complexes

Author(s): Tiago N Cordeiro, Fátima Herranz-Trillo, Annika Urbanek, Alejandro Estaña, Juan Cortés, Nathalie Sibille, Pau Bernadó
Published in: Current Opinion in Structural Biology, Issue 42, 2017, Page(s) 15-23, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2016.10.011

Book chapters (1)

Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering.

Author(s): Tiago N. Cordeiro, Fátima Herranz-Trillo, Annika Urbanek, Alejandro Estaña, Juan Cortés, Nathalie Sibille, Pau Bernadó
Published in: Advances in Experimental Medical Biology, 2017, Page(s) 107-129
Publisher: Springer Singapore
DOI: 10.1007/978-981-10-6038-0_7