Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure

Publicaciones

Preclinical development of a miR-132 inhibitor for heart failure treatment

Autores: Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatter
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14349-2

Living myocardial slices: a novel multicellular model for cardiac translational research

Autores: Filippo Perbellini, Thomas Thum
Publicado en: European Heart Journal, Edición 41/25, 2019, Página(s) 2405-2408, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehz779

Noncoding RNAs: potential regulators in cardioncology

Autores: Shambhabi Chatterjee, Shashi Kumar Gupta, Christian Bär, Thomas Thum
Publicado en: American Journal of Physiology-Heart and Circulatory Physiology, Edición 316/1, 2019, Página(s) H160-H168, ISSN 0363-6135
Editor: American Physiological Society
DOI: 10.1152/ajpheart.00418.2018

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

Autores: Nataliya Gorinski, Monika Bijata, Sonal Prasad, Alexander Wirth, Dalia Abdel Galil, Andre Zeug, Daria Bazovkina, Elena Kondaurova, Elizabeth Kulikova, Tatiana Ilchibaeva, Monika Zareba-Koziol, Francesco Papaleo, Diego Scheggia, Gaga Kochlamazashvili, Alexander Dityatev, Ian Smyth, Adam Krzystyniak, Jakub Wlodarczyk, Diethelm W. Richter, Tatyana Strekalova, Stephan Sigrist, Claudia Bang, Lisa Hobu
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-11876-5

A practical guide for investigating cardiac physiology using living myocardial slices

Autores: S. A. Watson, A. Dendorfer, T. Thum, F. Perbellini
Publicado en: Basic Research in Cardiology, Edición 115/6, 2020, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00822-y

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy

Autores: Janika Viereck, Anne Bührke, Ariana Foinquinos, Shambhabi Chatterjee, Jan A Kleeberger, Ke Xiao, Heike Janssen-Peters, Sandor Batkai, Deepak Ramanujam, Theresia Kraft, Serghei Cebotari, Faikah Gueler, Andreas M Beyer, Jessica Schmitz, Jan H Bräsen, Jan D Schmitto, Mariann Gyöngyösi, Alexandra Löser, Marc N Hirt, Thomas Eschenhagen, Stefan Engelhardt, Christian Bär, Thomas Thum
Publicado en: European Heart Journal, 2020, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehaa519

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

Autores: Laura Santer, Christian Bär, Thomas Thum
Publicado en: Molecular Therapy, Edición 27/8, 2019, Página(s) 1350-1363, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.001

Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology

Autores: Katharina Schimmel, Stevan D. Stojanović, Cheng-Kai Huang, Mira Jung, Martin H. Meyer, Ke Xiao, Lea Grote-Levi, Christian Bär, Angelika Pfanne, Saskia Mitzka, Annette Just, Robert Geffers, Katharina Bock, Franziska Kenneweg, Felix Kleemiß, Christine S. Falk, Jan Fiedler, Thomas Thum
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 150, 2021, Página(s) 91-100, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2020.10.008

Stimulating pro-reparative immune responses to prevent adverse cardiac remodelling: consensus document from the joint 2019 meeting of the ESC Working Groups of cellular biology of the heart and myocardial function

Autores: Sabine Steffens, Sophie Van Linthout, Joost P G Sluijter, Carlo Gabriele Tocchetti, Thomas Thum, Rosalinda Madonna
Publicado en: Cardiovascular Research, Edición 116/11, 2020, Página(s) 1850-1862, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvaa137

Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration

Autores: Naisam Abbas, Filippo Perbellini, Thomas Thum
Publicado en: Basic Research in Cardiology, Edición 115/5, 2020, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-0816-0

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Autores: Shashi Kumar Gupta, Ankita Garg, Petros Avramopoulos, Stefan Engelhardt, Katrin Streckfuss-Bömeke, Sandor Batkai, Thomas Thum
Publicado en: Molecular Therapy, Edición 27/1, 2019, Página(s) 17-28, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.004

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease

Autores: Laura Santer, Begoña López, Susana Ravassa, Christian Baer, Isabelle Riedel, Shambhabi Chatterjee, María U. Moreno, Arantxa González, Ramón Querejeta, Florence Pinet, Thomas Thum, Javier Díez
Publicado en: Hypertension, Edición 73/4, 2019, Página(s) 820-828, ISSN 0194-911X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.118.12261

TIP 30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Autores: Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, H
Publicado en: EMBO Molecular Medicine, Edición 11/10, 2019, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201810018

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Autores: Antoine Bondue, Eloisa Arbustini, Anna Bianco, Michele Ciccarelli, Dana Dawson, Matteo De Rosa, Nazha Hamdani, Denise Hilfiker-Kleiner, Benjamin Meder, Adelino F Leite-Moreira, Thomas Thum, Carlo G Tocchetti, Gilda Varricchi, Jolanda Van der Velden, Roddy Walsh, Stephane Heymans
Publicado en: Cardiovascular Research, Edición 114/10, 2018, Página(s) 1287-1303, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvy122

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Autores: Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-65115-9

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Autores: Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Publicado en: Circulation, Edición 143/14, 2021, Página(s) 1426-1449, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.049254

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis

Autores: Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer, Stephane Mazlan, Blanche Schroen, Steffie Hermans-Beijnsberger, Ariana Foinquinos, Marc N. Hirt, Thomas Eschenhagen, Sandra Funcke, Stevan Stojanovic, Celina Genschel, Katharina Schimmel, Annette Just, Angelika Pfanne, Kristian Scherf, Susann Dehmel, Stella M. Raemon-Buettner, Jan Fiedler, Thomas Thum
Publicado en: Molecular Therapy - Nucleic Acids, Edición 18, 2019, Página(s) 363-374, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2019.09.003

Non‐coding RNAs: key players in cardiac disease

Autores: Fabian Philipp Kreutzer, Jan Fiedler, Thomas Thum
Publicado en: The Journal of Physiology, Edición 598/14, 2020, Página(s) 2995-3003, ISSN 0022-3751
Editor: Blackwell Publishing Inc.
DOI: 10.1113/jp278131

SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure?

Autores: Thomas Thum
Publicado en: European Heart Journal, Edición 41/19, 2020, Página(s) 1807-1809, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehaa410

Studying Interactions between 2’-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis

Autores: Markus Herkt, Sandor Batkai, Thomas Thum
Publicado en: Molecular Therapy - Nucleic Acids, Edición 18, 2019, Página(s) 259-268, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2019.08.019

Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy

Autores: Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-80868-z

Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic DysfunctionNovelty and Significance

Autores: Maria-Teresa Piccoli, Shashi Kumar Gupta, Janika Viereck, Ariana Foinquinos, Sabine Samolovac, Freya Luise Kramer, Ankita Garg, Janet Remke, Karina Zimmer, Sandor Batkai, Thomas Thum
Publicado en: Circulation Research, Edición 121/5, 2017, Página(s) 575-583, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.310624

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

Autores: Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-01737-4

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure

Autores: Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum
Publicado en: European Journal of Heart Failure, 2017, ISSN 1388-9842
Editor: Elsevier BV
DOI: 10.1002/ejhf.961

Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury

Autores: Janika Viereck, Thomas Thum
Publicado en: Circulation Research, Edición 120/2, 2017, Página(s) 381-399, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.308434

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA ExpressionNovelty and Significance

Autores: Shashi Kumar Gupta, Ankita Garg, Christian Bär, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin Streckfuß-Bömeke, Jan Fiedler, Thomas Thum
Publicado en: Circulation Research, Edición 122/2, 2018, Página(s) 246-254, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.311335

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation

Autores: Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß, Regalla Kumarswamy, Katharina Schimmel, Christian Bär, Thomas Thum
Publicado en: Cell Death and Differentiation, Edición 25/2, 2017, Página(s) 307-318, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/cdd.2017.158

Nichtkodierende RNA

Autores: A. Bührke, C. Bär, T. Thum
Publicado en: Herz, 2017, ISSN 0340-9937
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00059-017-4660-4

Changing Direction

Autores: Christian Bär, Thomas Thum
Publicado en: Circulation Research, Edición 120/9, 2017, Página(s) 1393-1395, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.310316

Linc- ing the Noncoding Genome to Heart Function: Beating Hypertrophy

Autores: Shambhabi Chatterjee, Christian Bär, Thomas Thum
Publicado en: Trends in Molecular Medicine, Edición 23/7, 2017, Página(s) 577-579, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2017.05.007

Exosomal MicroRNAs Released by Pediatric Cardiac Progenitor Cells

Autores: Ke Xiao, Thomas Thum
Publicado en: Circulation Research, Edición 120/4, 2017, Página(s) 607-609, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.310443

Long Noncoding RNAs in Pathological Cardiac Remodeling

Autores: Janika Viereck, Thomas Thum
Publicado en: Circulation Research, Edición 120/2, 2017, Página(s) 262-264, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.310174

Circular RNAs in heart failure

Autores: Yvan Devaux, Esther E. Creemers, Reinier A. Boon, Stanislas Werfel, Thomas Thum, Stefan Engelhardt, Stefanie Dimmeler, Iain Squire
Publicado en: European Journal of Heart Failure, Edición 19/6, 2017, Página(s) 701-709, ISSN 1388-9842
Editor: Elsevier BV
DOI: 10.1002/ejhf.801

A long way for microRNAs to become meaningful prognostic biomarkers

Autores: Christian Bär, Thomas Thum
Publicado en: European Journal of Heart Failure, 2017, ISSN 1388-9842
Editor: Elsevier BV
DOI: 10.1002/ejhf.1036

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Autores: Cinzia Perrino, Albert-Laszló Barabási, Gianluigi Condorelli, Sean Michael Davidson, Leon De Windt, Stefanie Dimmeler, Felix Benedikt Engel, Derek John Hausenloy, Joseph Addison Hill, Linda Wilhelmina Van Laake, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Manuel Mayr, Fabrice Prunier, Joost Petrus Geradus Sluijter, Rainer Schulz, Thomas Thum, Kirsti Ytrehus, Péter Ferdinandy
Publicado en: Cardiovascular Research, Edición 113/7, 2017, Página(s) 725-736, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvx070

Circulating Long Noncoding RNAs in Personalized Medicine

Autores: David de Gonzalo-Calvo, Franziska Kenneweg, Claudia Bang, Rocío Toro, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W.A. Smit, Hildo J. Lamb, Vicenta Llorente-Cortes, Thomas Thum
Publicado en: Journal of the American College of Cardiology, Edición 68/25, 2016, Página(s) 2914-2916, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2016.10.014

Long noncoding RNA Chast promotes cardiac remodeling

Autores: J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum
Publicado en: Science Translational Medicine, Edición 8/326, 2016, Página(s) 326ra22-326ra22, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaf1475

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial FibrillationClinical Perspective

Autores: Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N. Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M. Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya
Publicado en: Circulation, Edición 134/11, 2016, Página(s) 817-832, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.115.016423

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance

Autores: Sandra C. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez, Tilman Schnick, Nadine Beetz, Achim Lother, Carolin Rommel, Hannah Ihle, Heiko Bugger, Frank Rühle, Andrea Schrepper, Michael Schwarzer, Claudia Heilmann, Ulrike Bönisch, Shashi Kumar Gupta, Jochen Wilpert, Oliver Kretz, Dominik von Elverfeldt, Joachim Orth, Klaus Aktories, Friedhelm Beyersdorf, Christoph Bode, Brigi
Publicado en: Circulation Research, Edición 117/7, 2015, Página(s) 622-633, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.115.306721

Non-coding RNAs as modulators of the cardiac fibroblast phenotype

Autores: Maria-Teresa Piccoli, Christian Bär, Thomas Thum
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 92, 2016, Página(s) 75-81, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2015.12.023

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Autores: D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R. W. van der Meer, L. J. Rijzewijk, J. W. Smit, H. J. Lamb, V. Llorente-Cortes, T. Thum
Publicado en: Scientific Reports, Edición 6, 2016, Página(s) 37354, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep37354

Antiageing concepts and cardiovascular disease

Autores: Thomas Thum
Publicado en: European Heart Journal, Edición 36/48, 2015, Página(s) 3435-3436, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehv412

Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima FormationSignificance

Autores: Jan-Marcus Daniel, André Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G. Sedding
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 36/2, 2016, Página(s) 317-327, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.115.305974

Non-coding RNAs as orchestrators of autophagic processes

Autores: Shashi Kumar Gupta, Thomas Thum
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 95, 2016, Página(s) 26-30, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2015.11.012

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy

Autores: Christian Bär, Shambhabi Chatterjee, Thomas Thum
Publicado en: Circulation, Edición 134/19, 2016, Página(s) 1484-1499, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.023686

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

Autores: Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum
Publicado en: Physiological Reviews, Edición 96/4, 2016, Página(s) 1297-1325, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00041.2015

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

Autores: Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A. Boon, Leon J. de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum
Publicado en: Journal of the American College of Cardiology, Edición 68/14, 2016, Página(s) 1557-1571, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2016.07.739

A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs

Autores: Meik Kunz, Beat Wolf, Maximilian Fuchs, Jan Christoph, Ke Xiao, Thomas Thum, David Atlan, Hans-Ulrich Prokosch, Thomas Dandekar
Publicado en: Briefings in Bioinformatics, Edición 21/4, 2019, Página(s) 1391-1396, ISSN 1477-4054
Editor: Oxford Academic
DOI: 10.1093/bib/bbz066

CircSlc8a1, breaking a vicious circle in cardiac hypertrophy

Autores: Christopher Jahn, Christian Bär, Thomas Thum
Publicado en: Cardiovascular Research, Edición 115/14, 2019, Página(s) 1946-1947, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvz147

Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy

Autores: Kristina Sonnenschein, Adriana Luisa Wilczek, David de Gonzalo-Calvo, Angelika Pfanne, Anselm Arthur Derda, Carolin Zwadlo, Udo Bavendiek, Johann Bauersachs, Jan Fiedler, Thomas Thum
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56617-2

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Autores: Katharina Schimmel, Mira Jung, Ariana Foinquinos, Gorka San José, Javier Beaumont, Katharina Bock, Lea Grote-Levi, Ke Xiao, Christian Bär, Angelika Pfanne, Annette Just, Karina Zimmer, Soeun Ngoy, Begoña López, Susana Ravassa, Sabine Samolovac, Heike Janssen-Peters, Janet Remke, Kristian Scherf, Seema Dangwal, Maria-Teresa Piccoli, Felix Kleemiss, Fabian Philipp Kreutzer, Franziska Kenneweg, J
Publicado en: Circulation, Edición 141/9, 2020, Página(s) 751-767, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042559

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

Autores: Cheng-Kai Huang, Sabine Kafert-Kasting, Thomas Thum
Publicado en: Circulation Research, Edición 126/5, 2020, Página(s) 663-678, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315856

Telomerase therapy attenuates cardiotoxic effects of doxorubicin

Autores: Shambhabi Chatterjee, Teresa Hofer, Alessia Costa, Dongchao Lu, Sandor Batkai, Shashi Kumar Gupta, Emiliano Bolesani, Robert Zweigerdt, Diego Megias, Katrin Streckfuss-Bömeke, Christina Brandenberger, Thomas Thum, Christian Bär
Publicado en: Molecular Therapy, 2021, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.12.035

Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry

Autores: Markus Herkt, Ariana Foinquinos, Sandor Batkai, Thomas Thum, Andreas Pich
Publicado en: Frontiers in Pharmacology, Edición 11, 2020, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00220

Translational Opportunities and Challenges of Long Noncoding RNAs in Cardiac Regeneration

Autores: Thomas Thum
Publicado en: Journal of the American College of Cardiology, Edición 72/5, 2018, Página(s) 551-552, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2018.05.039

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction

Autores: Mira Jung, Michael Dodsworth, Thomas Thum
Publicado en: Basic Research in Cardiology, Edición 114/1, 2019, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-018-0712-z

The Long Non-coding RNA Cyrano Is Dispensable for Pluripotency of Murine and Human Pluripotent Stem Cells

Autores: Hannah J. Hunkler, Jeannine Hoepfner, Cheng-Kai Huang, Shambhabi Chatterjee, Monica Jara-Avaca, Ina Gruh, Emiliano Bolesani, Robert Zweigerdt, Thomas Thum, Christian Bär
Publicado en: Stem Cell Reports, Edición 15/1, 2020, Página(s) 13-21, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2020.05.011

Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology

Autores: M. Sansonetti, F. J. G. Waleczek, M. Jung, T. Thum, F. Perbellini
Publicado en: Basic Research in Cardiology, Edición 115/6, 2020, ISSN 0300-8428
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00836-6

Derechos de propiedad intelectual

THE INCRNA MEG3 FOR THERAPY AND DIAGNOSIS OF CARDIAC REMODELLING

Número de solicitud/publicación: 17 722704
Fecha: 2017-04-26

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