Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure

Pubblicazioni

Preclinical development of a miR-132 inhibitor for heart failure treatment

Autori: Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatter
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14349-2

Living myocardial slices: a novel multicellular model for cardiac translational research

Autori: Filippo Perbellini, Thomas Thum
Pubblicato in: European Heart Journal, Numero 41/25, 2019, Pagina/e 2405-2408, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehz779

Noncoding RNAs: potential regulators in cardioncology

Autori: Shambhabi Chatterjee, Shashi Kumar Gupta, Christian Bär, Thomas Thum
Pubblicato in: American Journal of Physiology-Heart and Circulatory Physiology, Numero 316/1, 2019, Pagina/e H160-H168, ISSN 0363-6135
Editore: American Physiological Society
DOI: 10.1152/ajpheart.00418.2018

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

Autori: Nataliya Gorinski, Monika Bijata, Sonal Prasad, Alexander Wirth, Dalia Abdel Galil, Andre Zeug, Daria Bazovkina, Elena Kondaurova, Elizabeth Kulikova, Tatiana Ilchibaeva, Monika Zareba-Koziol, Francesco Papaleo, Diego Scheggia, Gaga Kochlamazashvili, Alexander Dityatev, Ian Smyth, Adam Krzystyniak, Jakub Wlodarczyk, Diethelm W. Richter, Tatyana Strekalova, Stephan Sigrist, Claudia Bang, Lisa Hobu
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11876-5

A practical guide for investigating cardiac physiology using living myocardial slices

Autori: S. A. Watson, A. Dendorfer, T. Thum, F. Perbellini
Pubblicato in: Basic Research in Cardiology, Numero 115/6, 2020, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00822-y

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy

Autori: Janika Viereck, Anne Bührke, Ariana Foinquinos, Shambhabi Chatterjee, Jan A Kleeberger, Ke Xiao, Heike Janssen-Peters, Sandor Batkai, Deepak Ramanujam, Theresia Kraft, Serghei Cebotari, Faikah Gueler, Andreas M Beyer, Jessica Schmitz, Jan H Bräsen, Jan D Schmitto, Mariann Gyöngyösi, Alexandra Löser, Marc N Hirt, Thomas Eschenhagen, Stefan Engelhardt, Christian Bär, Thomas Thum
Pubblicato in: European Heart Journal, 2020, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehaa519

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

Autori: Laura Santer, Christian Bär, Thomas Thum
Pubblicato in: Molecular Therapy, Numero 27/8, 2019, Pagina/e 1350-1363, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.001

Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology

Autori: Katharina Schimmel, Stevan D. Stojanović, Cheng-Kai Huang, Mira Jung, Martin H. Meyer, Ke Xiao, Lea Grote-Levi, Christian Bär, Angelika Pfanne, Saskia Mitzka, Annette Just, Robert Geffers, Katharina Bock, Franziska Kenneweg, Felix Kleemiß, Christine S. Falk, Jan Fiedler, Thomas Thum
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 150, 2021, Pagina/e 91-100, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2020.10.008

Stimulating pro-reparative immune responses to prevent adverse cardiac remodelling: consensus document from the joint 2019 meeting of the ESC Working Groups of cellular biology of the heart and myocardial function

Autori: Sabine Steffens, Sophie Van Linthout, Joost P G Sluijter, Carlo Gabriele Tocchetti, Thomas Thum, Rosalinda Madonna
Pubblicato in: Cardiovascular Research, Numero 116/11, 2020, Pagina/e 1850-1862, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvaa137

Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration

Autori: Naisam Abbas, Filippo Perbellini, Thomas Thum
Pubblicato in: Basic Research in Cardiology, Numero 115/5, 2020, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-0816-0

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity

Autori: Shashi Kumar Gupta, Ankita Garg, Petros Avramopoulos, Stefan Engelhardt, Katrin Streckfuss-Bömeke, Sandor Batkai, Thomas Thum
Pubblicato in: Molecular Therapy, Numero 27/1, 2019, Pagina/e 17-28, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.004

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease

Autori: Laura Santer, Begoña López, Susana Ravassa, Christian Baer, Isabelle Riedel, Shambhabi Chatterjee, María U. Moreno, Arantxa González, Ramón Querejeta, Florence Pinet, Thomas Thum, Javier Díez
Pubblicato in: Hypertension, Numero 73/4, 2019, Pagina/e 820-828, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.118.12261

TIP 30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Autori: Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, H
Pubblicato in: EMBO Molecular Medicine, Numero 11/10, 2019, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201810018

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Autori: Antoine Bondue, Eloisa Arbustini, Anna Bianco, Michele Ciccarelli, Dana Dawson, Matteo De Rosa, Nazha Hamdani, Denise Hilfiker-Kleiner, Benjamin Meder, Adelino F Leite-Moreira, Thomas Thum, Carlo G Tocchetti, Gilda Varricchi, Jolanda Van der Velden, Roddy Walsh, Stephane Heymans
Pubblicato in: Cardiovascular Research, Numero 114/10, 2018, Pagina/e 1287-1303, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy122

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Autori: Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-65115-9

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Autori: Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Pubblicato in: Circulation, Numero 143/14, 2021, Pagina/e 1426-1449, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.049254

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis

Autori: Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer, Stephane Mazlan, Blanche Schroen, Steffie Hermans-Beijnsberger, Ariana Foinquinos, Marc N. Hirt, Thomas Eschenhagen, Sandra Funcke, Stevan Stojanovic, Celina Genschel, Katharina Schimmel, Annette Just, Angelika Pfanne, Kristian Scherf, Susann Dehmel, Stella M. Raemon-Buettner, Jan Fiedler, Thomas Thum
Pubblicato in: Molecular Therapy - Nucleic Acids, Numero 18, 2019, Pagina/e 363-374, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2019.09.003

Non‐coding RNAs: key players in cardiac disease

Autori: Fabian Philipp Kreutzer, Jan Fiedler, Thomas Thum
Pubblicato in: The Journal of Physiology, Numero 598/14, 2020, Pagina/e 2995-3003, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp278131

SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure?

Autori: Thomas Thum
Pubblicato in: European Heart Journal, Numero 41/19, 2020, Pagina/e 1807-1809, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehaa410

Studying Interactions between 2’-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis

Autori: Markus Herkt, Sandor Batkai, Thomas Thum
Pubblicato in: Molecular Therapy - Nucleic Acids, Numero 18, 2019, Pagina/e 259-268, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2019.08.019

Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy

Autori: Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-80868-z

Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic DysfunctionNovelty and Significance

Autori: Maria-Teresa Piccoli, Shashi Kumar Gupta, Janika Viereck, Ariana Foinquinos, Sabine Samolovac, Freya Luise Kramer, Ankita Garg, Janet Remke, Karina Zimmer, Sandor Batkai, Thomas Thum
Pubblicato in: Circulation Research, Numero 121/5, 2017, Pagina/e 575-583, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.310624

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

Autori: Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01737-4

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure

Autori: Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum
Pubblicato in: European Journal of Heart Failure, 2017, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.961

Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury

Autori: Janika Viereck, Thomas Thum
Pubblicato in: Circulation Research, Numero 120/2, 2017, Pagina/e 381-399, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.308434

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA ExpressionNovelty and Significance

Autori: Shashi Kumar Gupta, Ankita Garg, Christian Bär, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin Streckfuß-Bömeke, Jan Fiedler, Thomas Thum
Pubblicato in: Circulation Research, Numero 122/2, 2018, Pagina/e 246-254, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.311335

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation

Autori: Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß, Regalla Kumarswamy, Katharina Schimmel, Christian Bär, Thomas Thum
Pubblicato in: Cell Death and Differentiation, Numero 25/2, 2017, Pagina/e 307-318, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/cdd.2017.158

Nichtkodierende RNA

Autori: A. Bührke, C. Bär, T. Thum
Pubblicato in: Herz, 2017, ISSN 0340-9937
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00059-017-4660-4

Changing Direction

Autori: Christian Bär, Thomas Thum
Pubblicato in: Circulation Research, Numero 120/9, 2017, Pagina/e 1393-1395, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.310316

Linc- ing the Noncoding Genome to Heart Function: Beating Hypertrophy

Autori: Shambhabi Chatterjee, Christian Bär, Thomas Thum
Pubblicato in: Trends in Molecular Medicine, Numero 23/7, 2017, Pagina/e 577-579, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2017.05.007

Exosomal MicroRNAs Released by Pediatric Cardiac Progenitor Cells

Autori: Ke Xiao, Thomas Thum
Pubblicato in: Circulation Research, Numero 120/4, 2017, Pagina/e 607-609, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.310443

Long Noncoding RNAs in Pathological Cardiac Remodeling

Autori: Janika Viereck, Thomas Thum
Pubblicato in: Circulation Research, Numero 120/2, 2017, Pagina/e 262-264, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.116.310174

Circular RNAs in heart failure

Autori: Yvan Devaux, Esther E. Creemers, Reinier A. Boon, Stanislas Werfel, Thomas Thum, Stefan Engelhardt, Stefanie Dimmeler, Iain Squire
Pubblicato in: European Journal of Heart Failure, Numero 19/6, 2017, Pagina/e 701-709, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.801

A long way for microRNAs to become meaningful prognostic biomarkers

Autori: Christian Bär, Thomas Thum
Pubblicato in: European Journal of Heart Failure, 2017, ISSN 1388-9842
Editore: Elsevier BV
DOI: 10.1002/ejhf.1036

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Autori: Cinzia Perrino, Albert-Laszló Barabási, Gianluigi Condorelli, Sean Michael Davidson, Leon De Windt, Stefanie Dimmeler, Felix Benedikt Engel, Derek John Hausenloy, Joseph Addison Hill, Linda Wilhelmina Van Laake, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Manuel Mayr, Fabrice Prunier, Joost Petrus Geradus Sluijter, Rainer Schulz, Thomas Thum, Kirsti Ytrehus, Péter Ferdinandy
Pubblicato in: Cardiovascular Research, Numero 113/7, 2017, Pagina/e 725-736, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx070

Circulating Long Noncoding RNAs in Personalized Medicine

Autori: David de Gonzalo-Calvo, Franziska Kenneweg, Claudia Bang, Rocío Toro, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W.A. Smit, Hildo J. Lamb, Vicenta Llorente-Cortes, Thomas Thum
Pubblicato in: Journal of the American College of Cardiology, Numero 68/25, 2016, Pagina/e 2914-2916, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2016.10.014

Long noncoding RNA Chast promotes cardiac remodeling

Autori: J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum
Pubblicato in: Science Translational Medicine, Numero 8/326, 2016, Pagina/e 326ra22-326ra22, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaf1475

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial FibrillationClinical Perspective

Autori: Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N. Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M. Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya
Pubblicato in: Circulation, Numero 134/11, 2016, Pagina/e 817-832, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.115.016423

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance

Autori: Sandra C. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez, Tilman Schnick, Nadine Beetz, Achim Lother, Carolin Rommel, Hannah Ihle, Heiko Bugger, Frank Rühle, Andrea Schrepper, Michael Schwarzer, Claudia Heilmann, Ulrike Bönisch, Shashi Kumar Gupta, Jochen Wilpert, Oliver Kretz, Dominik von Elverfeldt, Joachim Orth, Klaus Aktories, Friedhelm Beyersdorf, Christoph Bode, Brigi
Pubblicato in: Circulation Research, Numero 117/7, 2015, Pagina/e 622-633, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.115.306721

Non-coding RNAs as modulators of the cardiac fibroblast phenotype

Autori: Maria-Teresa Piccoli, Christian Bär, Thomas Thum
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 92, 2016, Pagina/e 75-81, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2015.12.023

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Autori: D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R. W. van der Meer, L. J. Rijzewijk, J. W. Smit, H. J. Lamb, V. Llorente-Cortes, T. Thum
Pubblicato in: Scientific Reports, Numero 6, 2016, Pagina/e 37354, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep37354

Antiageing concepts and cardiovascular disease

Autori: Thomas Thum
Pubblicato in: European Heart Journal, Numero 36/48, 2015, Pagina/e 3435-3436, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehv412

Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima FormationSignificance

Autori: Jan-Marcus Daniel, André Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G. Sedding
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 36/2, 2016, Pagina/e 317-327, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.115.305974

Non-coding RNAs as orchestrators of autophagic processes

Autori: Shashi Kumar Gupta, Thomas Thum
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 95, 2016, Pagina/e 26-30, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2015.11.012

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy

Autori: Christian Bär, Shambhabi Chatterjee, Thomas Thum
Pubblicato in: Circulation, Numero 134/19, 2016, Pagina/e 1484-1499, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.023686

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

Autori: Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum
Pubblicato in: Physiological Reviews, Numero 96/4, 2016, Pagina/e 1297-1325, ISSN 0031-9333
Editore: American Physiological Society
DOI: 10.1152/physrev.00041.2015

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

Autori: Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A. Boon, Leon J. de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum
Pubblicato in: Journal of the American College of Cardiology, Numero 68/14, 2016, Pagina/e 1557-1571, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2016.07.739

A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs

Autori: Meik Kunz, Beat Wolf, Maximilian Fuchs, Jan Christoph, Ke Xiao, Thomas Thum, David Atlan, Hans-Ulrich Prokosch, Thomas Dandekar
Pubblicato in: Briefings in Bioinformatics, Numero 21/4, 2019, Pagina/e 1391-1396, ISSN 1477-4054
Editore: Oxford Academic
DOI: 10.1093/bib/bbz066

CircSlc8a1, breaking a vicious circle in cardiac hypertrophy

Autori: Christopher Jahn, Christian Bär, Thomas Thum
Pubblicato in: Cardiovascular Research, Numero 115/14, 2019, Pagina/e 1946-1947, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvz147

Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy

Autori: Kristina Sonnenschein, Adriana Luisa Wilczek, David de Gonzalo-Calvo, Angelika Pfanne, Anselm Arthur Derda, Carolin Zwadlo, Udo Bavendiek, Johann Bauersachs, Jan Fiedler, Thomas Thum
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-56617-2

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Autori: Katharina Schimmel, Mira Jung, Ariana Foinquinos, Gorka San José, Javier Beaumont, Katharina Bock, Lea Grote-Levi, Ke Xiao, Christian Bär, Angelika Pfanne, Annette Just, Karina Zimmer, Soeun Ngoy, Begoña López, Susana Ravassa, Sabine Samolovac, Heike Janssen-Peters, Janet Remke, Kristian Scherf, Seema Dangwal, Maria-Teresa Piccoli, Felix Kleemiss, Fabian Philipp Kreutzer, Franziska Kenneweg, J
Pubblicato in: Circulation, Numero 141/9, 2020, Pagina/e 751-767, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042559

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

Autori: Cheng-Kai Huang, Sabine Kafert-Kasting, Thomas Thum
Pubblicato in: Circulation Research, Numero 126/5, 2020, Pagina/e 663-678, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315856

Telomerase therapy attenuates cardiotoxic effects of doxorubicin

Autori: Shambhabi Chatterjee, Teresa Hofer, Alessia Costa, Dongchao Lu, Sandor Batkai, Shashi Kumar Gupta, Emiliano Bolesani, Robert Zweigerdt, Diego Megias, Katrin Streckfuss-Bömeke, Christina Brandenberger, Thomas Thum, Christian Bär
Pubblicato in: Molecular Therapy, 2021, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.12.035

Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry

Autori: Markus Herkt, Ariana Foinquinos, Sandor Batkai, Thomas Thum, Andreas Pich
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00220

Translational Opportunities and Challenges of Long Noncoding RNAs in Cardiac Regeneration

Autori: Thomas Thum
Pubblicato in: Journal of the American College of Cardiology, Numero 72/5, 2018, Pagina/e 551-552, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2018.05.039

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction

Autori: Mira Jung, Michael Dodsworth, Thomas Thum
Pubblicato in: Basic Research in Cardiology, Numero 114/1, 2019, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-018-0712-z

The Long Non-coding RNA Cyrano Is Dispensable for Pluripotency of Murine and Human Pluripotent Stem Cells

Autori: Hannah J. Hunkler, Jeannine Hoepfner, Cheng-Kai Huang, Shambhabi Chatterjee, Monica Jara-Avaca, Ina Gruh, Emiliano Bolesani, Robert Zweigerdt, Thomas Thum, Christian Bär
Pubblicato in: Stem Cell Reports, Numero 15/1, 2020, Pagina/e 13-21, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.05.011

Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology

Autori: M. Sansonetti, F. J. G. Waleczek, M. Jung, T. Thum, F. Perbellini
Pubblicato in: Basic Research in Cardiology, Numero 115/6, 2020, ISSN 0300-8428
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-020-00836-6

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THE INCRNA MEG3 FOR THERAPY AND DIAGNOSIS OF CARDIAC REMODELLING

Numero candidatura/pubblicazione: 17 722704
Data: 2017-04-26

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