Towards solving myopia: from genes to pathways using an integrated approach

Informazioni relative al progetto

MYOP-PATH

ID dell’accordo di sovvenzione: 648268

DOI

10.3030/648268

Progetto chiuso

Data della firma CE 31 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 28 Febbraio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (15)

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Autori: Qiao Fan, Alfred Pozarickij, Nicholas Y. Q. Tan, Xiaobo Guo, Virginie J. M. Verhoeven, Veronique Vitart, Jeremy A. Guggenheim, Masahiro Miyake, J. Willem L. Tideman, Anthony P. Khawaja, Liang Zhang, Stuart MacGregor, René Höhn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S. Tedja, Jing Xie, Carla Lanca, Ya Xing Wang, Srujana Sahebjada, Johanna Mazur, Alireza Mirshahi, Nic
Pubblicato in: Communications Biology, Numero 3/1, 2020, ISSN 2399-3642
Editore: nature
DOI: 10.1038/s42003-020-0802-y

The Complications of Myopia: A Review and Meta-Analysis

Autori: Annechien E. G. Haarman, Clair A. Enthoven, J. Willem L. Tideman, Milly S. Tedja, Virginie J. M. Verhoeven, Caroline C. W. Klaver
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 61/4, 2020, Pagina/e 49, ISSN 1552-5783
Editore: ARVO journals
DOI: 10.1167/iovs.61.4.49

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Autori: Hysi, Pirro G; Choquet, Hélène; Khawaja, Anthony P; Wojciechowski, Robert; Tedja, Milly S; Yin, Jie; Simcoe, Mark J; Patasova, Karina; Mahroo, Omar A; Thai, Khanh K; Cumberland, Phillippa M; Melles, Ronald B; Verhoeven, Virginie JM; Vitart, Veronique; Segre, Ayellet; Stone, Richard A; Wareham, Nicholas; Hewitt, Alex W; Mackey, David A; Klaver, Caroline CW; MacGregor, Stuart; Consortium for Refra
Pubblicato in: Nature Genetics , 52 pp. 401-407. (2020), Numero 7, 2020, Pagina/e 401-407, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.17863/cam.63302

Growth in foetal life, infancy, and early childhood and the association with ocular biometry

Autori: Jan Willem L Tideman, Jan Roelof Polling, Vincent W V Jaddoe, Johannes R Vingerling, Caroline C W Klaver
Pubblicato in: Ophthalmic and Physiological Optics, Numero 39/4, 2019, Pagina/e 245-252, ISSN 0275-5408
Editore: Blackwell Publishing Inc.
DOI: 10.1111/opo.12630

Development of Refractive Errors—What Can We Learn From Inherited Retinal Dystrophies?

Autori: Michelle Hendriks, Virginie J.M. Verhoeven, Gabriëlle H.S. Buitendijk, Jan Roelof Polling, Magda A. Meester-Smoor, Albert Hofman, Maarten Kamermans, L. Ingeborgh van den Born, Caroline C.W. Klaver, Ramon A. van Huet, B. Jeroen Klevering, Nathalie M. Bax, Stanley Lambertus, Caroline C.W. Klaver, Carel B. Hoyng, Clasien J. Oomen, Wendy A. van Zelst-Stams, Frans P. Cremers, Astrid S. Plomp, Mary J.
Pubblicato in: American Journal of Ophthalmology, Numero 182, 2017, Pagina/e 81-89, ISSN 0002-9394
Editore: Elsevier BV
DOI: 10.1016/j.ajo.2017.07.008

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Autori: Milly S. Tedja, Robert Wojciechowski, Pirro G. Hysi, Nicholas Eriksson, Nicholas A. Furlotte, Virginie J. M. Verhoeven, Adriana I. Iglesias, Magda A. Meester-Smoor, Stuart W. Tompson, Qiao Fan, Anthony P. Khawaja, Ching-Yu Cheng, René Höhn, Kenji Yamashiro, Adam Wenocur, Clare Grazal, Toomas Haller, Andres Metspalu, Juho Wedenoja, Jost B. Jonas, Ya Xing Wang, Jing Xie, Paul Mitchell, Paul J. Fos
Pubblicato in: Nature Genetics, Numero 50/6, 2018, Pagina/e 834-848, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0127-7

Environmental Risk Factors Can Reduce Axial Length Elongation and Myopia Incidence in 6- to 9-Year-Old Children

Autori: J. Willem L. Tideman, Jan Roelof Polling, Vincent W.V. Jaddoe, Johannes R. Vingerling, Caroline C.W. Klaver
Pubblicato in: Ophthalmology, 2018, ISSN 0161-6420
Editore: Elsevier BV
DOI: 10.1016/j.ophtha.2018.06.029

A genome-wide association study for corneal astigmatism: The CREAM Consortium

Autori: Shah Rupal, Li Q, Zhao W, Tedja MS, Tideman WL, Khawaja A, Fan Q, Yazar S, Williams KM, Verhoeven VJM, Xie J, Wang YX, Hess M, Nickels S, Lackner KJ, Pärssinen O, Wedenoja J, Biino G, Concas MP, Uitterlinden A, Rivadeneira F, Jaddoe VWV, Hysi PG, Sim X, Tan N, Tham Y, Sensaki S, Hofman A, Vingerling JR, Jonas JB, Mitchell P, Hammond CJ, Höhn R, Baird PN, Wong TY, Cheng C, Teo YY, Mackey DA, Will
Pubblicato in: Molecular Vision, Numero vol. 24, 2018, Pagina/e 127-142, ISSN 1090-0535
Editore: Molecular Vision

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma

Autori: Adriana I. Iglesias, Jue Sheng Ong, Anthony P. Khawaja, Puya Gharahkhani, Milly S. Tedja, Virginie J. M. Verhoeven, Pieter W. M. Bonnemaijer, Roger C. W. Wolfs, Terri L. Young, Nomdo M. Jansonius, Jamie E. Craig, Dwight Stambolian, Cornelia M. van Duijn, Stuart MacGregor, Caroline C. W. Klaver
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 60/8, 2019, Pagina/e 3142, ISSN 1552-5783
Editore: ARVO Journals
DOI: 10.1167/iovs.18-26231

IMI – Myopia Genetics Report

Autori: Milly S. Tedja, Annechien E. G. Haarman, Magda A. Meester-Smoor, Jaakko Kaprio, David A. Mackey, Jeremy A. Guggenheim, Christopher J. Hammond, Virginie J. M. Verhoeven, Caroline C. W. Klaver
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 60/3, 2019, Pagina/e M89, ISSN 1552-5783
Editore: ARVO journals
DOI: 10.1167/iovs.18-25965

Evidence That Emmetropization Buffers Against Both Genetic and Environmental Risk Factors for Myopia

Autori: Alfred Pozarickij, Clair A. Enthoven, Neema Ghorbani Mojarrad, Denis Plotnikov, Milly S. Tedja, Annechien E.G. Haarman, J. Willem L. Tideman, Jan Roelof Polling, Kate Northstone, Cathy Williams, Caroline C. W. Klaver, Jeremy A. Guggenheim
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 61/2, 2020, Pagina/e 41, ISSN 1552-5783
Editore: IOVS
DOI: 10.1167/iovs.61.2.41

The impact of computer use on myopia development in childhood: The Generation R study

Autori: Clair A. Enthoven, J. Willem L. Tideman, Jan Roelof Polling, Junwen Yang-Huang, Hein Raat, Caroline C.W. Klaver
Pubblicato in: Preventive Medicine, Numero 132, 2020, Pagina/e 105988, ISSN 0091-7435
Editore: Academic Press
DOI: 10.1016/j.ypmed.2020.105988

Association of Rhegmatogenous Retinal Detachment Incidence With Myopia Prevalence in the Netherlands

Autori: Redmer van Leeuwen, Annechien E. G. Haarman, Mathijs A. J. van de Put, Caroline C. W. Klaver, Leonoor I. Los
Pubblicato in: JAMA Ophthalmology, Numero 139/1, 2021, Pagina/e 85, ISSN 2168-6165
Editore: American Medical Association
DOI: 10.1001/jamaophthalmol.2020.5114

Interaction between lifestyle and genetic susceptibility in myopia: the Generation R study

Autori: Caroline C W Klaver; Caroline C W Klaver; Jan Roelof Polling; Jan Willem L Tideman; Clair Enthoven; Hein Raat; Virginie J. M. Verhoeven; Adriana I. Iglesias; Milly S. Tedja
Pubblicato in: European Journal of Epidemiology, Numero 3, 2019, Pagina/e 777-784, ISSN 0393-2990
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10654-019-00512-7

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

Autori: Wim H. Quint, Kirke C. D. Tadema, Erik de Vrieze, Rachel M. Lukowicz, Sanne Broekman, Beerend H. J. Winkelman, Melanie Hoevenaars, H. Martijn de Gruiter, Erwin van Wijk, Frank Schaeffel, Magda Meester-Smoor, Adam C. Miller, Rob Willemsen, Caroline C. W. Klaver, Adriana I. Iglesias
Pubblicato in: Communications Biology, Numero 4/1, 2021, Pagina/e 1-14, ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-021-02185-z

Book chapters (1)

Advances in Vision Research, Volume IIIGenetic Eye Research around the Globe

Autori: Tedja, Haarman, Klaver, Verhoeven
Pubblicato in: 2020
Editore: Springer