New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche

Project Information

StemNicheOnWaveCrest

Grant agreement ID: 648765

DOI

10.3030/648765

Project closed

EC signature date 28 August 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 594 500,00

EU contribution

€ 1 594 500,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Author(s): Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Published in: Annals of the Rheumatic Diseases, Issue 79/12, 2020, Page(s) 1625-1634, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218350

Human and mouse leukocytes: different clockwork

Author(s): Simón Méndez-Ferrer
Published in: Blood, Issue 130/18, 2017, Page(s) 1960-1961, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2017-09-805374

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Author(s): Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06069-5

Role of <i>VHL</i>, <i>HIF1A</i> and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate

Author(s): Anna Merlo, Cristóbal Bernardo-Castiñeira, Inés Sáenz-de-Santa-María, Ana S Pitiot, Milagros Balbín, Aurora Astudillo, Nuria Valdés, Bartolomé Scola, Raquel Del Toro, Simón Méndez-Ferrer, José I Piruat, Carlos Suarez, María-Dolores Chiara
Published in: Oncotarget, Issue 8/4, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.14265

Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

Author(s): Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A. Bejarano-García, Jacques Zimmer, José A. Pérez-Simón, Juan J. Toledo-Aral, Tatiana Michel, Matti S. Airaksinen, Simón Méndez-Ferrer
Published in: Blood, Issue 133/3, 2019, Page(s) 224-236, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2018-08-867648

T-ALL: several homes rather than homeless?

Author(s): Justyna Rak, Simón Méndez-Ferrer
Published in: Immunology and Cell Biology, Issue 95/1, 2016, Page(s) 1-2, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1038/icb.2016.103

Nestin+ cells direct inflammatory cell migration in atherosclerosis

Author(s): Raquel del Toro, Raphael Chèvre, Cristina Rodríguez, Antonio Ordóñez, José Martínez-González, Vicente Andrés, Simón Méndez-Ferrer
Published in: Nature Communications, Issue 7, 2016, Page(s) 12706, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms12706

Under Pressure: When a Transformed Environment Pushes Cells to Malignancy

Author(s): María García-Fernández, Simón Méndez-Ferrer
Published in: Cell Stem Cell, Issue 19/5, 2016, Page(s) 559-560, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2016.10.012

The European Hematology Association Roadmap for European Hematology Research: a consensus document

Author(s): A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe
Published in: Haematologica, Issue 101/2, 2016, Page(s) 115-208, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.136739

Myeloid malignancies and the microenvironment

Author(s): Claudia Korn, Simón Méndez-Ferrer
Published in: Blood, Issue 129/7, 2017, Page(s) 811-822, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2016-09-670224

The hematopoietic stem-cell niche in health and leukemia

Author(s): Abel Sánchez-Aguilera, Simón Méndez-Ferrer
Published in: Cellular and Molecular Life Sciences, Issue 74/4, 2017, Page(s) 579-590, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-016-2306-y

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

Author(s): Ya-Hsuan Ho, Raquel del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto del Monte, Monika Wittner, Amie K. Waller, Holly R. Foster, Carlos López-Otín, Randall S. Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Published in: Cell Stem Cell, Issue 25/3, 2019, Page(s) 407-418.e6, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2019.06.007

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Author(s): Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D. Milsom, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Published in: Nature Cell Biology, Issue 21/11, 2019, Page(s) 1309-1320, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0418-y

Updates on the hematologic tumor microenvironment and its therapeutic targeting

Author(s): Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer
Published in: Haematologica, Issue 104/10, 2019, Page(s) 1928-1934, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195396

Molecular interactome between HSCs and their niches

Author(s): Simón Méndez-Ferrer
Published in: Blood, Issue 134/15, 2019, Page(s) 1197-1198, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019002615

Bone marrow niches in haematological malignancies

Author(s): Simón Méndez-Ferrer, Dominique Bonnet, David P. Steensma, Robert P. Hasserjian, Irene M. Ghobrial, John G. Gribben, Michael Andreeff , Daniela S. Krause
Published in: Nature Reviews Cancer, 2020, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-020-0245-2

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

Author(s): Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S. Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K. Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekate
Published in: Cell Stem Cell, Issue 23/4, 2018, Page(s) 572-585.e7, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.08.002

The sympathomimetic agonist mirabegron did not lower JAK2 -V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14

Author(s): Beatrice Drexler, Jakob R. Passweg, Alexandar Tzankov, Martin Bigler, Alexandre PA Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G. Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C. Skoda
Published in: Haematologica, Issue 104/4, 2019, Page(s) 710-716, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.200014

Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension

Author(s): David Ramos, Joana Catita, Mariana López-Luppo, Andreia Valença, Aina Bonet, Ana Carretero, Marc Navarro, Victor Nacher, Simon Mendez-Ferrer, Anna Meseguer, Alba Casellas, Luísa Mendes-Jorge, Jesús Ruberte
Published in: Investigative Opthalmology & Visual Science, Issue 60/2, 2019, Page(s) 473, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.18-25000

Microenvironmental contributions to hematopoietic stem cell aging

Author(s): Ya-Hsuan Ho, Simón Méndez-Ferrer
Published in: Haematologica, Issue 105/1, 2020, Page(s) 38-46, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.211334

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Author(s): Dorian Forte, María García-Fernández, Abel Sánchez-Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana S.H. Costa, Laura Tronci, Efterpi Nikitopoulou, Michael Barber, Paolo Gallipoli, Ludovica Marando, Carlos López Fernández de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michele Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza
Published in: Cell Metabolism, Issue 32/5, 2020, Page(s) 829-843.e9, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.09.001

Neuronal regulation of bone marrow stem cell niches

Author(s): Claire Fielding, Simón Méndez-Ferrer
Published in: F1000Research, Issue 9, 2020, Page(s) 614, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.22554.1