New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche

Pubblicazioni

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Autori: Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Pubblicato in: Annals of the Rheumatic Diseases, Numero 79/12, 2020, Pagina/e 1625-1634, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218350

Human and mouse leukocytes: different clockwork

Autori: Simón Méndez-Ferrer
Pubblicato in: Blood, Numero 130/18, 2017, Pagina/e 1960-1961, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2017-09-805374

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Autori: Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06069-5

Role of <i>VHL</i>, <i>HIF1A</i> and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate

Autori: Anna Merlo, Cristóbal Bernardo-Castiñeira, Inés Sáenz-de-Santa-María, Ana S Pitiot, Milagros Balbín, Aurora Astudillo, Nuria Valdés, Bartolomé Scola, Raquel Del Toro, Simón Méndez-Ferrer, José I Piruat, Carlos Suarez, María-Dolores Chiara
Pubblicato in: Oncotarget, Numero 8/4, 2017, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.14265

Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

Autori: Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A. Bejarano-García, Jacques Zimmer, José A. Pérez-Simón, Juan J. Toledo-Aral, Tatiana Michel, Matti S. Airaksinen, Simón Méndez-Ferrer
Pubblicato in: Blood, Numero 133/3, 2019, Pagina/e 224-236, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2018-08-867648

T-ALL: several homes rather than homeless?

Autori: Justyna Rak, Simón Méndez-Ferrer
Pubblicato in: Immunology and Cell Biology, Numero 95/1, 2016, Pagina/e 1-2, ISSN 0818-9641
Editore: Blackwell Publishing Inc.
DOI: 10.1038/icb.2016.103

Nestin+ cells direct inflammatory cell migration in atherosclerosis

Autori: Raquel del Toro, Raphael Chèvre, Cristina Rodríguez, Antonio Ordóñez, José Martínez-González, Vicente Andrés, Simón Méndez-Ferrer
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 12706, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms12706

Under Pressure: When a Transformed Environment Pushes Cells to Malignancy

Autori: María García-Fernández, Simón Méndez-Ferrer
Pubblicato in: Cell Stem Cell, Numero 19/5, 2016, Pagina/e 559-560, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2016.10.012

The European Hematology Association Roadmap for European Hematology Research: a consensus document

Autori: A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe
Pubblicato in: Haematologica, Numero 101/2, 2016, Pagina/e 115-208, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.136739

Myeloid malignancies and the microenvironment

Autori: Claudia Korn, Simón Méndez-Ferrer
Pubblicato in: Blood, Numero 129/7, 2017, Pagina/e 811-822, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2016-09-670224

The hematopoietic stem-cell niche in health and leukemia

Autori: Abel Sánchez-Aguilera, Simón Méndez-Ferrer
Pubblicato in: Cellular and Molecular Life Sciences, Numero 74/4, 2017, Pagina/e 579-590, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-016-2306-y

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

Autori: Ya-Hsuan Ho, Raquel del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto del Monte, Monika Wittner, Amie K. Waller, Holly R. Foster, Carlos López-Otín, Randall S. Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Pubblicato in: Cell Stem Cell, Numero 25/3, 2019, Pagina/e 407-418.e6, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2019.06.007

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Autori: Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D. Milsom, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Pubblicato in: Nature Cell Biology, Numero 21/11, 2019, Pagina/e 1309-1320, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-019-0418-y

Updates on the hematologic tumor microenvironment and its therapeutic targeting

Autori: Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer
Pubblicato in: Haematologica, Numero 104/10, 2019, Pagina/e 1928-1934, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195396

Molecular interactome between HSCs and their niches

Autori: Simón Méndez-Ferrer
Pubblicato in: Blood, Numero 134/15, 2019, Pagina/e 1197-1198, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019002615

Bone marrow niches in haematological malignancies

Autori: Simón Méndez-Ferrer, Dominique Bonnet, David P. Steensma, Robert P. Hasserjian, Irene M. Ghobrial, John G. Gribben, Michael Andreeff , Daniela S. Krause
Pubblicato in: Nature Reviews Cancer, 2020, ISSN 1474-175X
Editore: Nature Publishing Group
DOI: 10.1038/s41568-020-0245-2

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

Autori: Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S. Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K. Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekate
Pubblicato in: Cell Stem Cell, Numero 23/4, 2018, Pagina/e 572-585.e7, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2018.08.002

The sympathomimetic agonist mirabegron did not lower JAK2 -V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14

Autori: Beatrice Drexler, Jakob R. Passweg, Alexandar Tzankov, Martin Bigler, Alexandre PA Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G. Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C. Skoda
Pubblicato in: Haematologica, Numero 104/4, 2019, Pagina/e 710-716, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.200014

Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension

Autori: David Ramos, Joana Catita, Mariana López-Luppo, Andreia Valença, Aina Bonet, Ana Carretero, Marc Navarro, Victor Nacher, Simon Mendez-Ferrer, Anna Meseguer, Alba Casellas, Luísa Mendes-Jorge, Jesús Ruberte
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 60/2, 2019, Pagina/e 473, ISSN 1552-5783
Editore: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.18-25000

Microenvironmental contributions to hematopoietic stem cell aging

Autori: Ya-Hsuan Ho, Simón Méndez-Ferrer
Pubblicato in: Haematologica, Numero 105/1, 2020, Pagina/e 38-46, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.211334

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Autori: Dorian Forte, María García-Fernández, Abel Sánchez-Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana S.H. Costa, Laura Tronci, Efterpi Nikitopoulou, Michael Barber, Paolo Gallipoli, Ludovica Marando, Carlos López Fernández de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michele Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza
Pubblicato in: Cell Metabolism, Numero 32/5, 2020, Pagina/e 829-843.e9, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.09.001

Neuronal regulation of bone marrow stem cell niches

Autori: Claire Fielding, Simón Méndez-Ferrer
Pubblicato in: F1000Research, Numero 9, 2020, Pagina/e 614, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.22554.1

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