Structure of paramagnetic integral membrane metalloproteins by MAS-NMR

Información del proyecto

P-MEM-NMR

Identificador del acuerdo de subvención: 648974

DOI

10.3030/648974

Proyecto cerrado

Fecha de la firma de la CE 6 Julio 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 375,00

Aportación de la UE

€ 2 499 375,00

Coordinado por

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (30)

Probing Membrane Protein Insertion into Lipid Bilayers by Solid‐State NMR

Autores: Eszter E. Najbauer, Kumar Tekwani Movellan, Tobias Schubeis, Tom Schwarzer, Kathrin Castiglione, Karin Giller, Guido Pintacuda, Stefan Becker, Loren B. Andreas
Publicado en: ChemPhysChem, 2018, ISSN 1439-4235
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201800793

Multimodal Response to Copper Binding in Superoxide Dismutase Dynamics

Autores: Marta Bonaccorsi, Michael J. Knight, Tanguy Le Marchand, Hugh R. W. Dannatt, Tobias Schubeis, Loïc Salmon, Isabella C. Felli, Lyndon Emsley, Roberta Pierattelli, Guido Pintacuda
Publicado en: Journal of the American Chemical Society, Edición 142/46, 2020, Página(s) 19660-19667, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c09242

Backbone assignment of crystalline E. coli maltose binding protein

Autores: Tobias Schubeis, Jan Stanek, Guido Pintacuda
Publicado en: Biomolecular NMR Assignments, Edición 15/2, 2021, Página(s) 317-322, ISSN 1874-2718
Editor: Springer Verlag
DOI: 10.1007/s12104-021-10023-w

Structural and molecular basis of cross-seeding barriers in amyloids

Autores: Asen Daskalov, Denis Martinez, Virginie Coustou, Nadia El Mammeri, Mélanie Berbon, Loren B. Andreas, Benjamin Bardiaux, Jan Stanek, Abdelmajid Noubhani, Brice Kauffmann, Joseph S. Wall, Guido Pintacuda, Sven J. Saupe, Birgit Habenstein, Antoine Loquet
Publicado en: Proceedings of the National Academy of Sciences, Edición 118/1, 2020, Página(s) e2014085118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2014085118

A β-barrel for oil transport through lipid membranes: Dynamic NMR structures of AlkL

Autores: Tobias Schubeis, Tanguy Le Marchand, Csaba Daday, Wojciech Kopec, Kumar Tekwani Movellan, Jan Stanek, Tom S. Schwarzer, Kathrin Castiglione, Bert L. de Groot, Guido Pintacuda, Loren B. Andreas
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/35, 2020, Página(s) 21014-21021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2002598117

Paramagnetic NMR in solution and the solid state

Autores: Andrew J. Pell, Guido Pintacuda, Clare P. Grey
Publicado en: Progress in Nuclear Magnetic Resonance Spectroscopy, Edición 111, 2019, Página(s) 1-271, ISSN 0079-6565
Editor: Elsevier BV
DOI: 10.1016/j.pnmrs.2018.05.001

Picometer Resolution Structure of the Coordination Sphere in the Metal-Binding Site in a Metalloprotein by NMR

Autores: Andrea Bertarello, Ladislav Benda, Kevin J. Sanders, Andrew J. Pell, Michael J. Knight, Vladimir Pelmenschikov, Leonardo Gonnelli, Isabella C. Felli, Martin Kaupp, Lyndon Emsley, Roberta Pierattelli, Guido Pintacuda
Publicado en: Journal of the American Chemical Society, Edición 142/39, 2020, Página(s) 16757-16765, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c07339

Resonance assignment of the outer membrane protein AlkL in lipid bilayers by proton-detected solid-state NMR

Autores: Tobias Schubeis, Tom S. Schwarzer, Tanguy Le Marchand, Jan Stanek, Kumar Tekwani Movellan, Kathrin Castiglione, Guido Pintacuda, Loren B. Andreas
Publicado en: Biomolecular NMR Assignments, Edición 14/2, 2020, Página(s) 295-300, ISSN 1874-2718
Editor: Springer Verlag
DOI: 10.1007/s12104-020-09964-5

Proton-detected fast-magic-angle spinning NMR of paramagnetic inorganic solids

Autores: Jan Blahut, Ladislav Benda, Arthur L. Lejeune, Kevin J. Sanders, Benjamin Burcher, Erwann Jeanneau, David Proriol, Leonor Catita, Pierre-Alain R. Breuil, Anne-Agathe Quoineaud, Andrew J. Pell, Guido Pintacuda
Publicado en: RSC Advances, Edición 11/47, 2021, Página(s) 29870-29876, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/d1ra04110j

Protein structural dynamics by Magic-Angle Spinning NMR

Autores: Marta Bonaccorsi, Tanguy Le Marchand, Guido Pintacuda
Publicado en: Current Opinion in Structural Biology, Edición 70, 2021, Página(s) 34-43, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2021.02.008

Monitoring Dynamics, Structure, and Magnetism of Switchable Metal–Organic Frameworks via 1 H‐Detected MAS NMR

Autores: Jan Blahut, Arthur L. Lejeune, Sebastian Ehrling, Irena Senkovska, Stefan Kaskel, Florian M. Wisser, Guido Pintacuda
Publicado en: Angewandte Chemie International Edition, Edición 60/40, 2021, Página(s) 21778-21783, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202107032

Structural Analysis of an Antigen Chemically Coupled on Virus‐Like Particles in Vaccine Formulation

Autores: Kristaps Jaudzems, Anna Kirsteina, Tobias Schubeis, Gilles Casano, Olivier Ouari, Janis Bogans, Andris Kazaks, Kaspars Tars, Anne Lesage, Guido Pintacuda
Publicado en: Angewandte Chemie International Edition, Edición 60/23, 2021, Página(s) 12847-12851, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202013189

Protein NMR Resonance Assignment without Spectral Analysis: 5D SOlid‐State Automated Projection SpectroscopY (SO‐APSY)

Autores: Henry W. Orton, Jan Stanek, Tobias Schubeis, Dylan Foucaudeau, Claire Ollier, Adrian W. Draney, Tanguy Le Marchand, Diane Cala‐De Paepe, Isabella C. Felli, Roberta Pierattelli, Sebastian Hiller, Wolfgang Bermel, Guido Pintacuda
Publicado en: Angewandte Chemie International Edition, Edición 59/6, 2020, Página(s) 2380-2384, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201912211

Impact of Magnetic Field Strength on Resolution and Sensitivity of Proton Resonances in Biological Solids

Autores: Kai Xue, Riddhiman Sarkar, Daniela Lalli, Benita Koch, Guido Pintacuda, Zdenek Tosner, Bernd Reif
Publicado en: The Journal of Physical Chemistry C, Edición 124/41, 2020, Página(s) 22631-22637, ISSN 1932-7447
Editor: American Chemical Society
DOI: 10.1021/acs.jpcc.0c05407

Proton-Based Structural Analysis of a Heptahelical Transmembrane Protein in Lipid Bilayers

Autores: Daniela Lalli, Matthew N. Idso, Loren B. Andreas, Sunyia Hussain, Naomi Baxter, Songi Han, Bradley F. Chmelka, Guido Pintacuda
Publicado en: Journal of the American Chemical Society, Edición 139/37, 2017, Página(s) 13006-13012, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b05269

Selective 1 H– 1 H Distance Restraints in Fully Protonated Proteins by Very Fast Magic-Angle Spinning Solid-State NMR

Autores: Mukul G. Jain, Daniela Lalli, Jan Stanek, Chandrakala Gowda, Satya Prakash, Tom S. Schwarzer, Tobias Schubeis, Kathrin Castiglione, Loren B. Andreas, P. K. Madhu, Guido Pintacuda, Vipin Agarwal
Publicado en: The Journal of Physical Chemistry Letters, Edición 8/11, 2017, Página(s) 2399-2405, ISSN 1948-7185
Editor: American Chemical Society
DOI: 10.1021/acs.jpclett.7b00983

Paramagnetic Properties of a Crystalline Iron–Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy

Autores: Andrea Bertarello, Tobias Schubeis, Carmelo Fuccio, Enrico Ravera, Marco Fragai, Giacomo Parigi, Lyndon Emsley, Guido Pintacuda, Claudio Luchinat
Publicado en: Inorganic Chemistry, Edición 56/11, 2017, Página(s) 6624-6629, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.7b00674

NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils

Autores: Jan Stanek, Loren B. Andreas, Kristaps Jaudzems, Diane Cala, Daniela Lalli, Andrea Bertarello, Tobias Schubeis, Inara Akopjana, Svetlana Kotelovica, Kaspars Tars, Andrea Pica, Serena Leone, Delia Picone, Zhi-Qiang Xu, Nicholas E. Dixon, Denis Martinez, Mélanie Berbon, Nadia El Mammeri, Abdelmajid Noubhani, Sven Saupe, Birgit Habenstein, Antoine Loquet, Guido Pintacuda
Publicado en: Angewandte Chemie International Edition, Edición 55/50, 2016, Página(s) 15504-15509, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201607084

Structure of fully protonated proteins by proton-detected magic-angle spinning NMR

Autores: Loren B. Andreas, Kristaps Jaudzems, Jan Stanek, Daniela Lalli, Andrea Bertarello, Tanguy Le Marchand, Diane Cala-De Paepe, Svetlana Kotelovica, Inara Akopjana, Benno Knott, Sebastian Wegner, Frank Engelke, Anne Lesage, Lyndon Emsley, Kaspars Tars, Torsten Herrmann, Guido Pintacuda
Publicado en: Proceedings of the National Academy of Sciences, Edición 113/33, 2016, Página(s) 9187-9192, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1602248113

1 H magic-angle spinning NMR evolves as a powerful new tool for membrane proteins

Autores: Tobias Schubeis, Tanguy Le Marchand, Loren B. Andreas, Guido Pintacuda
Publicado en: Journal of Magnetic Resonance, Edición 287, 2018, Página(s) 140-152, ISSN 1090-7807
Editor: Academic Press
DOI: 10.1016/j.jmr.2017.11.014

Low-power broadband solid-state MAS NMR of 14 N

Autores: Andrew J. Pell, Kevin J. Sanders, Sebastian Wegner, Guido Pintacuda, Clare P. Grey
Publicado en: The Journal of Chemical Physics, Edición 146/19, 2017, Página(s) 194202, ISSN 0021-9606
Editor: American Institute of Physics
DOI: 10.1063/1.4983220

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity

Autores: Tanguy Le Marchand, Matteo de Rosa, Nicola Salvi, Benedetta Maria Sala, Loren B. Andreas, Emeline Barbet-Massin, Pietro Sormanni, Alberto Barbiroli, Riccardo Porcari, Cristiano Sousa Mota, Daniele de Sanctis, Martino Bolognesi, Lyndon Emsley, Vittorio Bellotti, Martin Blackledge, Carlo Camilloni, Guido Pintacuda, Stefano Ricagno
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04078-y

Is protein deuteration beneficial for proton detected solid-state NMR at and above 100 kHz magic-angle spinning?

Autores: Diane Cala-De Paepe, Jan Stanek, Kristaps Jaudzems, Kaspars Tars, Loren B. Andreas, Guido Pintacuda
Publicado en: Solid State Nuclear Magnetic Resonance, Edición 87, 2017, Página(s) 126-136, ISSN 0926-2040
Editor: Academic Press
DOI: 10.1016/j.ssnmr.2017.07.004

Straightforward Access to Stable, 16-Valence-Electron Phosphine-Stabilized Fe 0 Olefin Complexes and Their Reactivity

Autores: Benjamin Burcher, Kevin J. Sanders, Ladislav Benda, Guido Pintacuda, Erwann Jeanneau, Andreas A. Danopoulos, Pierre Braunstein, Hélène Olivier-Bourbigou, Pierre-Alain R. Breuil
Publicado en: Organometallics, Edición 36/3, 2017, Página(s) 605-613, ISSN 0276-7333
Editor: American Chemical Society
DOI: 10.1021/acs.organomet.6b00803

Local and Global Dynamics in Klebsiella pneumoniae Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution

Autores: Olivier Saurel, Iordan Iordanov, Guillaume Nars, Pascal Demange, Tanguy Le Marchand, Loren B. Andreas, Guido Pintacuda, Alain Milon
Publicado en: Journal of the American Chemical Society, Edición 139/4, 2017, Página(s) 1590-1597, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.6b11565

Broadband MAS NMR spectroscopy in the low-power limit

Autores: Kevin J. Sanders, Andrew J. Pell, Sebastian Wegner, Clare P. Grey, Guido Pintacuda
Publicado en: Chemical Physics Letters, Edición 697, 2018, Página(s) 29-37, ISSN 0009-2614
Editor: Elsevier BV
DOI: 10.1016/j.cplett.2018.01.028

3D structure determination of amyloid fibrils using solid-state NMR spectroscopy

Autores: Antoine Loquet, Nadia El Mammeri, Jan Stanek, Mélanie Berbon, Benjamin Bardiaux, Guido Pintacuda, Birgit Habenstein
Publicado en: Methods, 2018, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2018.03.014

Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS

Autores: Alexander Marchanka, Jan Stanek, Guido Pintacuda, Teresa Carlomagno
Publicado en: Chemical Communications, Edición 54/65, 2018, Página(s) 8972-8975, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c8cc04437f

MAS dependent sensitivity of different isotopomers in selectively methyl protonated protein samples in solid state NMR

Autores: Kai Xue, Riddhiman Sarkar, Zdenek Tosner, Daniela Lalli, Carina Motz, Benita Koch, Guido Pintacuda, Bernd Reif
Publicado en: Journal of Biomolecular NMR, Edición 73/10-11, 2019, Página(s) 625-631, ISSN 0925-2738
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10858-019-00274-0

Automated Backbone NMR Resonance Assignment of Large Proteins Using Redundant Linking from a Single Simultaneous Acquisition

Autores: Jan Stanek, Tobias Schubeis, Piotr Paluch, Peter Güntert, Loren B. Andreas, Guido Pintacuda
Publicado en: Journal of the American Chemical Society, Edición 142/12, 2020, Página(s) 5793-5799, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c00251

Non-peer reviewed articles (1)

Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation

Autores: Nicolai Tidemand Johansen, Marta Bonaccorsi, Tone Bengtsen, Andreas Haahr Larsen, Frederik Grønbæk Tidemand, Martin Cramer Pedersen, Pie Huda, Jens Berndtsson, Tamim Darwish, Nageshwar Rao Yepuri, Anne Martel, Thomas Günther Pomorski, Andrea Bertarello, Mark Sansom, Mikaela Rapp, Ramon Crehuet, Tobias Schubeis, Kresten Lindorff-Larsen, Guido Pintacuda, Lise Arleth
Publicado en: bioRxiv, 2021, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.08.20.457080