Linking Cardiometabolic Disease and Cancer in the Level of Genetics, Circulating Biomarkers, Microbiota and Environmental Risk Factors

Project Information

BIOMENDELIAN

Grant agreement ID: 649021

DOI 10.3030/649021

Project closed

EC signature date 22 June 2015

Start date 1 September 2015

End date 31 August 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

LUNDS UNIVERSITET
Sweden

Publications

Peer reviewed articles (18)

Dietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI

Author(s): Gull Rukh, Ulrika Ericson, Johanna Andersson-Assarsson, Marju Orho-Melander, Emily Sonestedt
Published in: American Journal of Clinical Nutrition, 2017, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.3945/ajcn.116.149831

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Author(s): Einar Smith, Filip Ottosson, Sophie Hellstrand, Ulrika Ericson, Marju Orho-Melander, Céline Fernandez, Olle Melander
Published in: Heart, Issue 106/9, 2020, Page(s) 691-697, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2019-315485

Comparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors

Author(s): Stina Ramne, Nicola Gray, Sophie Hellstrand, Louise Brunkwall, Sofia Enhörning, Peter M. Nilsson, Gunnar Engström, Marju Orho-Melander, Ulrika Ericson, Gunter G. C. Kuhnle, Emily Sonestedt
Published in: Frontiers in Nutrition, Issue 7, 2020, ISSN 2296-861X
Publisher: Frontiers Media SA
DOI: 10.3389/fnut.2020.00062

Type 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting

Author(s): Isabel Drake, Bo Gullberg, Emily Sonestedt, Tanja Stocks, Anders Bjartell, Elisabet Wirfält, Peter Wallström, Marju Orho-Melander
Published in: International Journal of Cancer, Issue 141/6, 2017, Page(s) 1170-1180, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30824

The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities

Author(s): Louise Brunkwall, Marju Orho-Melander
Published in: Diabetologia, Issue 60/6, 2017, Page(s) 943-951, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4278-3

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8

Author(s): Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
Published in: Genes & Nutrition, Issue 12/1, 2017, ISSN 1555-8932
Publisher: New Century Health Publishers
DOI: 10.1186/s12263-017-0586-y

Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study

Author(s): Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Published in: International Journal of Epidemiology, Issue 47/2, 2017, Page(s) 495-505, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyx237

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes

Author(s): George Hindy, Gunnar Engström, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, Olle Melander, Marju Orho-Melander
Published in: Stroke, Issue 49/4, 2018, Page(s) 820-827, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019653

Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota

Author(s): Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M Nilsson, Peter Almgren, Céline Fernandez, Olle Melander, Marju Orho-Melander
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/4, 2018, Page(s) 1491-1501, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/jc.2017-02114

Dietary and genetic risk scores and incidence of type 2 diabetes

Author(s): Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren, Marju Orho-Melander
Published in: Genes & Nutrition, Issue 13/1, 2018, ISSN 1555-8932
Publisher: New Century Health Publishers
DOI: 10.1186/s12263-018-0599-1

Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) and Impaired Kidney Function in the Population-based Malmö Diet and Cancer Study

Author(s): Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, Peter M. Nilsson, Olle Melander, Gunnar Engström, Marju Orho-Melander
Published in: Kidney International Reports, Issue 2/2, 2017, Page(s) 239-247, ISSN 2468-0249
Publisher: Elsevier
DOI: 10.1016/j.ekir.2016.11.004

High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD

Author(s): Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M. Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander, Marju Orho-Melander
Published in: Journal of the American Society of Nephrology, Issue 28/1, 2016, Page(s) 291-303, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2015101177

An obligatory role for neurotensin in high-fat-diet-induced obesity

Author(s): Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang
Published in: Nature, Issue 533/7603, 2016, Page(s) 411-415, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature17662

A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study

Author(s): Ulrika Ericson, Louise Brunkwall, Sophie Hellstrand, Peter M Nilsson, Marju Orho-Melander
Published in: The Journal of Nutrition, Issue 150 (4), 2020, Page(s) 861-872, ISSN 1541-6100
Publisher: American Society of Nutrition
DOI: 10.1093/jn/nxz293

Genetic Predisposition for Renal Dysfunction and Incidence of CKD in the Malmö Diet and Cancer Study

Author(s): Christina-Alexandra Schulz, Gunnar Engström, Anders Christensson, Peter M. Nilsson, Olle Melander, Marju Orho-Melander
Published in: Kidney International Reports, Issue 4/8, 2019, Page(s) 1143-1151, ISSN 2468-0249
Publisher: Elsevier inc
DOI: 10.1016/j.ekir.2019.05.003

A favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort

Author(s): Kristian Dimovski, Marju Orho-Melander, Isabel Drake
Published in: BMC Public Health, Issue 19/1, 2019, Page(s) 1575-1583, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-019-7948-x

Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years

Author(s): Christina-Alexandra Schulz, Gunnar Engström, Jan Nilsson, Peter Almgren, Marinka Petkovic, Anders Christensson, Peter M Nilsson, Olle Melander, Marju Orho-Melander
Published in: Nephrology Dialysis Transplantation, Issue 35/2, 2019, Page(s) 265-273, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfy382

Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

Author(s): George Hindy, Kristina E. Åkesson, Olle Melander, Krishna G. Aragam, Mary E. Haas, Peter M. Nilsson, Umesh T. Kadam, Marju Orho‐Melander
Published in: Arthritis & Rheumatology, Issue 71/6, 2019, Page(s) 925-934, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40812