Linking Cardiometabolic Disease and Cancer in the Level of Genetics, Circulating Biomarkers, Microbiota and Environmental Risk Factors

Informazioni relative al progetto

BIOMENDELIAN

ID dell’accordo di sovvenzione: 649021

DOI 10.3030/649021

Progetto chiuso

Data della firma CE 22 Giugno 2015

Data di avvio 1 Settembre 2015

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

LUNDS UNIVERSITET
Sweden

Pubblicazioni

Peer reviewed articles (18)

Dietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI

Autori: Gull Rukh, Ulrika Ericson, Johanna Andersson-Assarsson, Marju Orho-Melander, Emily Sonestedt
Pubblicato in: American Journal of Clinical Nutrition, 2017, ISSN 0002-9165
Editore: American Society for Clinical Nutrition, Inc.
DOI: 10.3945/ajcn.116.149831

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Autori: Einar Smith, Filip Ottosson, Sophie Hellstrand, Ulrika Ericson, Marju Orho-Melander, Céline Fernandez, Olle Melander
Pubblicato in: Heart, Numero 106/9, 2020, Pagina/e 691-697, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2019-315485

Comparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors

Autori: Stina Ramne, Nicola Gray, Sophie Hellstrand, Louise Brunkwall, Sofia Enhörning, Peter M. Nilsson, Gunnar Engström, Marju Orho-Melander, Ulrika Ericson, Gunter G. C. Kuhnle, Emily Sonestedt
Pubblicato in: Frontiers in Nutrition, Numero 7, 2020, ISSN 2296-861X
Editore: Frontiers Media SA
DOI: 10.3389/fnut.2020.00062

Type 2 diabetes, adiposity and cancer morbidity and mortality risk taking into account competing risk of noncancer deaths in a prospective cohort setting

Autori: Isabel Drake, Bo Gullberg, Emily Sonestedt, Tanja Stocks, Anders Bjartell, Elisabet Wirfält, Peter Wallström, Marju Orho-Melander
Pubblicato in: International Journal of Cancer, Numero 141/6, 2017, Pagina/e 1170-1180, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30824

The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities

Autori: Louise Brunkwall, Marju Orho-Melander
Pubblicato in: Diabetologia, Numero 60/6, 2017, Pagina/e 943-951, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4278-3

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8

Autori: Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
Pubblicato in: Genes & Nutrition, Numero 12/1, 2017, ISSN 1555-8932
Editore: New Century Health Publishers
DOI: 10.1186/s12263-017-0586-y

Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study

Autori: Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Pubblicato in: International Journal of Epidemiology, Numero 47/2, 2017, Pagina/e 495-505, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyx237

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes

Autori: George Hindy, Gunnar Engström, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, Olle Melander, Marju Orho-Melander
Pubblicato in: Stroke, Numero 49/4, 2018, Pagina/e 820-827, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.117.019653

Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota

Autori: Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M Nilsson, Peter Almgren, Céline Fernandez, Olle Melander, Marju Orho-Melander
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 103/4, 2018, Pagina/e 1491-1501, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/jc.2017-02114

Dietary and genetic risk scores and incidence of type 2 diabetes

Autori: Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren, Marju Orho-Melander
Pubblicato in: Genes & Nutrition, Numero 13/1, 2018, ISSN 1555-8932
Editore: New Century Health Publishers
DOI: 10.1186/s12263-018-0599-1

Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) and Impaired Kidney Function in the Population-based Malmö Diet and Cancer Study

Autori: Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, Peter M. Nilsson, Olle Melander, Gunnar Engström, Marju Orho-Melander
Pubblicato in: Kidney International Reports, Numero 2/2, 2017, Pagina/e 239-247, ISSN 2468-0249
Editore: Elsevier
DOI: 10.1016/j.ekir.2016.11.004

High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD

Autori: Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M. Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander, Marju Orho-Melander
Pubblicato in: Journal of the American Society of Nephrology, Numero 28/1, 2016, Pagina/e 291-303, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2015101177

An obligatory role for neurotensin in high-fat-diet-induced obesity

Autori: Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang
Pubblicato in: Nature, Numero 533/7603, 2016, Pagina/e 411-415, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature17662

A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study

Autori: Ulrika Ericson, Louise Brunkwall, Sophie Hellstrand, Peter M Nilsson, Marju Orho-Melander
Pubblicato in: The Journal of Nutrition, Numero 150 (4), 2020, Pagina/e 861-872, ISSN 1541-6100
Editore: American Society of Nutrition
DOI: 10.1093/jn/nxz293

Genetic Predisposition for Renal Dysfunction and Incidence of CKD in the Malmö Diet and Cancer Study

Autori: Christina-Alexandra Schulz, Gunnar Engström, Anders Christensson, Peter M. Nilsson, Olle Melander, Marju Orho-Melander
Pubblicato in: Kidney International Reports, Numero 4/8, 2019, Pagina/e 1143-1151, ISSN 2468-0249
Editore: Elsevier inc
DOI: 10.1016/j.ekir.2019.05.003

A favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort

Autori: Kristian Dimovski, Marju Orho-Melander, Isabel Drake
Pubblicato in: BMC Public Health, Numero 19/1, 2019, Pagina/e 1575-1583, ISSN 1471-2458
Editore: BioMed Central
DOI: 10.1186/s12889-019-7948-x

Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years

Autori: Christina-Alexandra Schulz, Gunnar Engström, Jan Nilsson, Peter Almgren, Marinka Petkovic, Anders Christensson, Peter M Nilsson, Olle Melander, Marju Orho-Melander
Pubblicato in: Nephrology Dialysis Transplantation, Numero 35/2, 2019, Pagina/e 265-273, ISSN 0931-0509
Editore: Oxford University Press
DOI: 10.1093/ndt/gfy382

Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

Autori: George Hindy, Kristina E. Åkesson, Olle Melander, Krishna G. Aragam, Mary E. Haas, Peter M. Nilsson, Umesh T. Kadam, Marju Orho‐Melander
Pubblicato in: Arthritis & Rheumatology, Numero 71/6, 2019, Pagina/e 925-934, ISSN 2326-5191
Editore: Wiley
DOI: 10.1002/art.40812