Bio-Imaging of Zoonotic and Emerging Bunyaviruses

Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data

Author(s): Vahid Abrishami, Serban L. Ilca, Josue Gomez-Blanco, Ilona Rissanen, José Miguel de la Rosa-Trevín, Vijay S. Reddy, José-Maria Carazo, Juha T. Huiskonen
Published in: Progress in Biophysics and Molecular Biology, 2020, ISSN 0079-6107
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2020.05.004

High-Resolution Description of the Hantavirus Surface Glycoprotein Lattice and Its Membrane Fusion Control Mechanism

Author(s): Alexandra Serris, Robert Stass, Eduardo A. Bignon, Nicolas A. Muena, Jean-Claude Manuguerra, Rohit K. Jangra, Sai Li, Kartik Chandran, Nicole Tischler, Juha T. Huiskonen, Felix Augusto Rey, Pablo Guardado-Calvo
Published in: SSRN Electronic Journal, 2020, ISSN 1556-5068
Publisher: Elsevier
DOI: 10.2139/ssrn.3596593

Shielding and activation of a viral membrane fusion protein

Author(s): Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02789-2

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Author(s): Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Annamaria Tessitore, Leela Shrestha, Shubhashish Mukhopadhyay, Pravin Mahajan, Rod Chalk, Nicola A Burgess-Brown, Rebecca Sitsapesan, Juha T Huiskonen, Elisabeth P Carpenter
Published in: Nature Structural & Molecular Biology, Issue 24/2, 2017, Page(s) 114-122, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3343

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Author(s): Nayab Malik, Abhay Kotecha, Sarah Gold, Amin Asfor, Jingshan Ren, Juha T. Huiskonen, Tobias J. Tuthill, Elizabeth E. Fry, David I. Stuart
Published in: PLOS Pathogens, Issue 13/9, 2017, Page(s) e1006607, ISSN 1553-7374
Publisher: The Public Library of Science
DOI: 10.1371/journal.ppat.1006607

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope

Author(s): Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J. C. Gilbert, Juha T. Huiskonen, Thomas A. Bowden
Published in: Journal of Virology, Issue 91/21, 2017, Page(s) e00378-17, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.00378-17

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Author(s): Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki, Soizick Lucas-Staat, Ying Liu, Mart Krupovic, Simon E. V. Phillips, David Prangishvili, Juha T. Huiskonen
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01668-0

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Author(s): Steinar Halldorsson, Anna-Janina Behrens, Karl Harlos, Juha T. Huiskonen, Richard M Elliott, Max Crispin, Benjamin Brennan, and Thomas A Bowden
Published in: P Natl Acad Sci Usa, 2016, ISSN 1091-6490
Publisher: PNAS
DOI: 10.1073/pnas.1603827113

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Author(s): Serban L. Ilca, Abhay Kotecha, Xiaoyu Sun, Minna M. Poranen, David I. Stuart, Juha T. Huiskonen
Published in: Nature Communications, Issue 6, 2015, Page(s) 8843, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms9843

Low pH and Anionic Lipid-dependent Fusion of Uukuniemi Phlebovirus to Liposomes*

Author(s): Bitto, David; Halldorsson, Steinar; Huiskonen, Juha T; Caputo, Alessandro
Published in: The Journal of Biological Chemistry, 2016, ISSN 1083-351X
Publisher: American Society for Biochemistry and Molecular Biology
DOI: 10.1074/jbc.M115.691113

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

Author(s): Renner, Max; Leyrat, Cédric; Huiskonen, Juha T; Paesen, Guido C; Bertinelli, Mattia; Saraiva de Oliveira, Laura Freitas; Grimes, Jonathan M.
Published in: eLife, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.12627

A Molecular-Level Account of the Antigenic Hantaviral Surface

Author(s): Sai Li; Ilona Rissanen; Jayna Raghwani; Thomas A. Bowden; Juha T. Huiskonen; Antra Zeltina; Jussi Hepojoki; Karl Harlos; Oliver G. Pybus
Published in: Cell Reports, Issue 1, 2016, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.03.082

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

Author(s): Kamel El Omari, Sai Li, Abhay Kotecha, Thomas S. Walter, Eduardo A. Bignon, Karl Harlos, Pentti Somerharju, Felix De Haas, Daniel K. Clare, Mika Molin, Felipe Hurtado, Mengqiu Li, Jonathan M. Grimes, Dennis H. Bamford, Nicole D. Tischler, Juha T. Huiskonen, David I. Stuart, Elina Roine
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08728-7

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Author(s): Elizabeth R. Allen, Stefanie A. Krumm, Jayna Raghwani, Steinar Halldorsson, Angela Elliott, Victoria A. Graham, Elina Koudriakova, Karl Harlos, Daniel Wright, George M. Warimwe, Benjamin Brennan, Juha T. Huiskonen, Stuart D. Dowall, Richard M. Elliott, Oliver G. Pybus, Dennis R. Burton, Roger Hewson, Katie J. Doores, Thomas A. Bowden
Published in: Cell Reports, Issue 25/13, 2018, Page(s) 3750-3758.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.12.001

Structure of the Lassa virus glycan shield provides a model for immunological resistance

Author(s): Yasunori Watanabe, Jayna Raghwani, Joel D. Allen, Gemma E. Seabright, Sai Li, Felipe Moser, Juha T. Huiskonen, Thomas Strecker, Thomas A. Bowden, Max Crispin
Published in: Proceedings of the National Academy of Sciences, Issue 115/28, 2018, Page(s) 7320-7325, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1803990115

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Author(s): César López-Camacho, Young Chan Kim, Joshua Blight, Marcos Lazaro Moreli, Eduardo Montoya-Diaz, Juha T Huiskonen, Beate Mareike Kümmerer, Arturo Reyes-Sandoval
Published in: Viruses, Issue 11/4, 2019, Page(s) 322, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11040322

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Author(s): Max Renner, Aleksandra Flanagan, Wanwisa Dejnirattisai, Chunya Puttikhunt, Watchara Kasinrerk, Piyada Supasa, Wiyada Wongwiwat, Kriangkrai Chawansuntati, Thaneeya Duangchinda, Alison Cowper, Claire M. Midgley, Prida Malasit, Juha T. Huiskonen, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Published in: Nature Immunology, Issue 19/11, 2018, Page(s) 1248-1256, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0227-7

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

Author(s): Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09451-z

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

Author(s): Serban L. Ilca, Xiaoyu Sun, Kamel El Omari, Abhay Kotecha, Felix de Haas, Frank DiMaio, Jonathan M. Grimes, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Published in: Nature, Issue 570/7760, 2019, Page(s) 252-256, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1229-9

Beyond structures of highly symmetric purified viral capsids by cryo-EM

Author(s): Robert Stass, Serban L Ilca, Juha T Huiskonen
Published in: Current Opinion in Structural Biology, Issue 52, 2018, Page(s) 25-31, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2018.07.011

Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes

Author(s): Juha T. Huiskonen
Published in: Bioscience Reports, Issue 38/2, 2018, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/bsr20170203

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Author(s): Zhaoyang Sun, Kamel El Omari, Xiaoyu Sun, Serban L. Ilca, Abhay Kotecha, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Published in: Nature Communications, Issue 8, 2017, Page(s) 14814, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14814

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Author(s): Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Published in: Nature Communications, Issue 8, 2017, Page(s) 15408, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15408

Structures of enveloped virions determined by cryogenic electron microscopy and tomography

Author(s): Robert Stass, Weng M. Ng, Young Chan Kim, Juha T. Huiskonen
Published in: Complementary Strategies to Understand Virus Structure and Function, Issue 105, 2019, Page(s) 35-71, ISBN 9780-128184561
Publisher: Elsevier
DOI: 10.1016/bs.aivir.2019.07.009

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

Author(s): Ilona Rissanen, Robert Stass, Stefanie A. Krumm, Jeffrey Seow, Ruben J.G. Hulswit, Guido C. Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J. Doores, Juha T. Huiskonen, Thomas A. Bowden
Published in: bioRxiv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.04.17.029876

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