Bio-Imaging of Zoonotic and Emerging Bunyaviruses

Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data

Autori: Vahid Abrishami, Serban L. Ilca, Josue Gomez-Blanco, Ilona Rissanen, José Miguel de la Rosa-Trevín, Vijay S. Reddy, José-Maria Carazo, Juha T. Huiskonen
Pubblicato in: Progress in Biophysics and Molecular Biology, 2020, ISSN 0079-6107
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2020.05.004

High-Resolution Description of the Hantavirus Surface Glycoprotein Lattice and Its Membrane Fusion Control Mechanism

Autori: Alexandra Serris, Robert Stass, Eduardo A. Bignon, Nicolas A. Muena, Jean-Claude Manuguerra, Rohit K. Jangra, Sai Li, Kartik Chandran, Nicole Tischler, Juha T. Huiskonen, Felix Augusto Rey, Pablo Guardado-Calvo
Pubblicato in: SSRN Electronic Journal, 2020, ISSN 1556-5068
Editore: Elsevier
DOI: 10.2139/ssrn.3596593

Shielding and activation of a viral membrane fusion protein

Autori: Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02789-2

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Autori: Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Annamaria Tessitore, Leela Shrestha, Shubhashish Mukhopadhyay, Pravin Mahajan, Rod Chalk, Nicola A Burgess-Brown, Rebecca Sitsapesan, Juha T Huiskonen, Elisabeth P Carpenter
Pubblicato in: Nature Structural & Molecular Biology, Numero 24/2, 2017, Pagina/e 114-122, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/nsmb.3343

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Autori: Nayab Malik, Abhay Kotecha, Sarah Gold, Amin Asfor, Jingshan Ren, Juha T. Huiskonen, Tobias J. Tuthill, Elizabeth E. Fry, David I. Stuart
Pubblicato in: PLOS Pathogens, Numero 13/9, 2017, Pagina/e e1006607, ISSN 1553-7374
Editore: The Public Library of Science
DOI: 10.1371/journal.ppat.1006607

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope

Autori: Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J. C. Gilbert, Juha T. Huiskonen, Thomas A. Bowden
Pubblicato in: Journal of Virology, Numero 91/21, 2017, Pagina/e e00378-17, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.00378-17

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Autori: Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki, Soizick Lucas-Staat, Ying Liu, Mart Krupovic, Simon E. V. Phillips, David Prangishvili, Juha T. Huiskonen
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01668-0

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Autori: Steinar Halldorsson, Anna-Janina Behrens, Karl Harlos, Juha T. Huiskonen, Richard M Elliott, Max Crispin, Benjamin Brennan, and Thomas A Bowden
Pubblicato in: P Natl Acad Sci Usa, 2016, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.1603827113

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Autori: Serban L. Ilca, Abhay Kotecha, Xiaoyu Sun, Minna M. Poranen, David I. Stuart, Juha T. Huiskonen
Pubblicato in: Nature Communications, Numero 6, 2015, Pagina/e 8843, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms9843

Low pH and Anionic Lipid-dependent Fusion of Uukuniemi Phlebovirus to Liposomes*

Autori: Bitto, David; Halldorsson, Steinar; Huiskonen, Juha T; Caputo, Alessandro
Pubblicato in: The Journal of Biological Chemistry, 2016, ISSN 1083-351X
Editore: American Society for Biochemistry and Molecular Biology
DOI: 10.1074/jbc.M115.691113

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

Autori: Renner, Max; Leyrat, Cédric; Huiskonen, Juha T; Paesen, Guido C; Bertinelli, Mattia; Saraiva de Oliveira, Laura Freitas; Grimes, Jonathan M.
Pubblicato in: eLife, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.12627

A Molecular-Level Account of the Antigenic Hantaviral Surface

Autori: Sai Li; Ilona Rissanen; Jayna Raghwani; Thomas A. Bowden; Juha T. Huiskonen; Antra Zeltina; Jussi Hepojoki; Karl Harlos; Oliver G. Pybus
Pubblicato in: Cell Reports, Numero 1, 2016, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.03.082

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

Autori: Kamel El Omari, Sai Li, Abhay Kotecha, Thomas S. Walter, Eduardo A. Bignon, Karl Harlos, Pentti Somerharju, Felix De Haas, Daniel K. Clare, Mika Molin, Felipe Hurtado, Mengqiu Li, Jonathan M. Grimes, Dennis H. Bamford, Nicole D. Tischler, Juha T. Huiskonen, David I. Stuart, Elina Roine
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08728-7

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Autori: Elizabeth R. Allen, Stefanie A. Krumm, Jayna Raghwani, Steinar Halldorsson, Angela Elliott, Victoria A. Graham, Elina Koudriakova, Karl Harlos, Daniel Wright, George M. Warimwe, Benjamin Brennan, Juha T. Huiskonen, Stuart D. Dowall, Richard M. Elliott, Oliver G. Pybus, Dennis R. Burton, Roger Hewson, Katie J. Doores, Thomas A. Bowden
Pubblicato in: Cell Reports, Numero 25/13, 2018, Pagina/e 3750-3758.e4, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.12.001

Structure of the Lassa virus glycan shield provides a model for immunological resistance

Autori: Yasunori Watanabe, Jayna Raghwani, Joel D. Allen, Gemma E. Seabright, Sai Li, Felipe Moser, Juha T. Huiskonen, Thomas Strecker, Thomas A. Bowden, Max Crispin
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/28, 2018, Pagina/e 7320-7325, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1803990115

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Autori: César López-Camacho, Young Chan Kim, Joshua Blight, Marcos Lazaro Moreli, Eduardo Montoya-Diaz, Juha T Huiskonen, Beate Mareike Kümmerer, Arturo Reyes-Sandoval
Pubblicato in: Viruses, Numero 11/4, 2019, Pagina/e 322, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11040322

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Autori: Max Renner, Aleksandra Flanagan, Wanwisa Dejnirattisai, Chunya Puttikhunt, Watchara Kasinrerk, Piyada Supasa, Wiyada Wongwiwat, Kriangkrai Chawansuntati, Thaneeya Duangchinda, Alison Cowper, Claire M. Midgley, Prida Malasit, Juha T. Huiskonen, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Pubblicato in: Nature Immunology, Numero 19/11, 2018, Pagina/e 1248-1256, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0227-7

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

Autori: Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09451-z

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

Autori: Serban L. Ilca, Xiaoyu Sun, Kamel El Omari, Abhay Kotecha, Felix de Haas, Frank DiMaio, Jonathan M. Grimes, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Pubblicato in: Nature, Numero 570/7760, 2019, Pagina/e 252-256, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1229-9

Beyond structures of highly symmetric purified viral capsids by cryo-EM

Autori: Robert Stass, Serban L Ilca, Juha T Huiskonen
Pubblicato in: Current Opinion in Structural Biology, Numero 52, 2018, Pagina/e 25-31, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2018.07.011

Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes

Autori: Juha T. Huiskonen
Pubblicato in: Bioscience Reports, Numero 38/2, 2018, ISSN 0144-8463
Editore: Kluwer Academic Publishers
DOI: 10.1042/bsr20170203

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Autori: Zhaoyang Sun, Kamel El Omari, Xiaoyu Sun, Serban L. Ilca, Abhay Kotecha, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 14814, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms14814

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Autori: Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15408, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15408

Structures of enveloped virions determined by cryogenic electron microscopy and tomography

Autori: Robert Stass, Weng M. Ng, Young Chan Kim, Juha T. Huiskonen
Pubblicato in: Complementary Strategies to Understand Virus Structure and Function, Numero 105, 2019, Pagina/e 35-71, ISBN 9780-128184561
Editore: Elsevier
DOI: 10.1016/bs.aivir.2019.07.009

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

Autori: Ilona Rissanen, Robert Stass, Stefanie A. Krumm, Jeffrey Seow, Ruben J.G. Hulswit, Guido C. Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J. Doores, Juha T. Huiskonen, Thomas A. Bowden
Pubblicato in: bioRxiv, 2020
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.04.17.029876

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