Bio-Imaging of Zoonotic and Emerging Bunyaviruses

Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data

Autores: Vahid Abrishami, Serban L. Ilca, Josue Gomez-Blanco, Ilona Rissanen, José Miguel de la Rosa-Trevín, Vijay S. Reddy, José-Maria Carazo, Juha T. Huiskonen
Publicado en: Progress in Biophysics and Molecular Biology, 2020, ISSN 0079-6107
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2020.05.004

High-Resolution Description of the Hantavirus Surface Glycoprotein Lattice and Its Membrane Fusion Control Mechanism

Autores: Alexandra Serris, Robert Stass, Eduardo A. Bignon, Nicolas A. Muena, Jean-Claude Manuguerra, Rohit K. Jangra, Sai Li, Kartik Chandran, Nicole Tischler, Juha T. Huiskonen, Felix Augusto Rey, Pablo Guardado-Calvo
Publicado en: SSRN Electronic Journal, 2020, ISSN 1556-5068
Editor: Elsevier
DOI: 10.2139/ssrn.3596593

Shielding and activation of a viral membrane fusion protein

Autores: Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02789-2

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Autores: Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Annamaria Tessitore, Leela Shrestha, Shubhashish Mukhopadhyay, Pravin Mahajan, Rod Chalk, Nicola A Burgess-Brown, Rebecca Sitsapesan, Juha T Huiskonen, Elisabeth P Carpenter
Publicado en: Nature Structural & Molecular Biology, Edición 24/2, 2017, Página(s) 114-122, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/nsmb.3343

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Autores: Nayab Malik, Abhay Kotecha, Sarah Gold, Amin Asfor, Jingshan Ren, Juha T. Huiskonen, Tobias J. Tuthill, Elizabeth E. Fry, David I. Stuart
Publicado en: PLOS Pathogens, Edición 13/9, 2017, Página(s) e1006607, ISSN 1553-7374
Editor: The Public Library of Science
DOI: 10.1371/journal.ppat.1006607

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope

Autores: Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J. C. Gilbert, Juha T. Huiskonen, Thomas A. Bowden
Publicado en: Journal of Virology, Edición 91/21, 2017, Página(s) e00378-17, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00378-17

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Autores: Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki, Soizick Lucas-Staat, Ying Liu, Mart Krupovic, Simon E. V. Phillips, David Prangishvili, Juha T. Huiskonen
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-01668-0

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Autores: Steinar Halldorsson, Anna-Janina Behrens, Karl Harlos, Juha T. Huiskonen, Richard M Elliott, Max Crispin, Benjamin Brennan, and Thomas A Bowden
Publicado en: P Natl Acad Sci Usa, 2016, ISSN 1091-6490
Editor: PNAS
DOI: 10.1073/pnas.1603827113

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Autores: Serban L. Ilca, Abhay Kotecha, Xiaoyu Sun, Minna M. Poranen, David I. Stuart, Juha T. Huiskonen
Publicado en: Nature Communications, Edición 6, 2015, Página(s) 8843, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms9843

Low pH and Anionic Lipid-dependent Fusion of Uukuniemi Phlebovirus to Liposomes*

Autores: Bitto, David; Halldorsson, Steinar; Huiskonen, Juha T; Caputo, Alessandro
Publicado en: The Journal of Biological Chemistry, 2016, ISSN 1083-351X
Editor: American Society for Biochemistry and Molecular Biology
DOI: 10.1074/jbc.M115.691113

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

Autores: Renner, Max; Leyrat, Cédric; Huiskonen, Juha T; Paesen, Guido C; Bertinelli, Mattia; Saraiva de Oliveira, Laura Freitas; Grimes, Jonathan M.
Publicado en: eLife, 2016, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.12627

A Molecular-Level Account of the Antigenic Hantaviral Surface

Autores: Sai Li; Ilona Rissanen; Jayna Raghwani; Thomas A. Bowden; Juha T. Huiskonen; Antra Zeltina; Jussi Hepojoki; Karl Harlos; Oliver G. Pybus
Publicado en: Cell Reports, Edición 1, 2016, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.03.082

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

Autores: Kamel El Omari, Sai Li, Abhay Kotecha, Thomas S. Walter, Eduardo A. Bignon, Karl Harlos, Pentti Somerharju, Felix De Haas, Daniel K. Clare, Mika Molin, Felipe Hurtado, Mengqiu Li, Jonathan M. Grimes, Dennis H. Bamford, Nicole D. Tischler, Juha T. Huiskonen, David I. Stuart, Elina Roine
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08728-7

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Autores: Elizabeth R. Allen, Stefanie A. Krumm, Jayna Raghwani, Steinar Halldorsson, Angela Elliott, Victoria A. Graham, Elina Koudriakova, Karl Harlos, Daniel Wright, George M. Warimwe, Benjamin Brennan, Juha T. Huiskonen, Stuart D. Dowall, Richard M. Elliott, Oliver G. Pybus, Dennis R. Burton, Roger Hewson, Katie J. Doores, Thomas A. Bowden
Publicado en: Cell Reports, Edición 25/13, 2018, Página(s) 3750-3758.e4, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.12.001

Structure of the Lassa virus glycan shield provides a model for immunological resistance

Autores: Yasunori Watanabe, Jayna Raghwani, Joel D. Allen, Gemma E. Seabright, Sai Li, Felipe Moser, Juha T. Huiskonen, Thomas Strecker, Thomas A. Bowden, Max Crispin
Publicado en: Proceedings of the National Academy of Sciences, Edición 115/28, 2018, Página(s) 7320-7325, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1803990115

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Autores: César López-Camacho, Young Chan Kim, Joshua Blight, Marcos Lazaro Moreli, Eduardo Montoya-Diaz, Juha T Huiskonen, Beate Mareike Kümmerer, Arturo Reyes-Sandoval
Publicado en: Viruses, Edición 11/4, 2019, Página(s) 322, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11040322

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Autores: Max Renner, Aleksandra Flanagan, Wanwisa Dejnirattisai, Chunya Puttikhunt, Watchara Kasinrerk, Piyada Supasa, Wiyada Wongwiwat, Kriangkrai Chawansuntati, Thaneeya Duangchinda, Alison Cowper, Claire M. Midgley, Prida Malasit, Juha T. Huiskonen, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Publicado en: Nature Immunology, Edición 19/11, 2018, Página(s) 1248-1256, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0227-7

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

Autores: Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09451-z

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

Autores: Serban L. Ilca, Xiaoyu Sun, Kamel El Omari, Abhay Kotecha, Felix de Haas, Frank DiMaio, Jonathan M. Grimes, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Publicado en: Nature, Edición 570/7760, 2019, Página(s) 252-256, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1229-9

Beyond structures of highly symmetric purified viral capsids by cryo-EM

Autores: Robert Stass, Serban L Ilca, Juha T Huiskonen
Publicado en: Current Opinion in Structural Biology, Edición 52, 2018, Página(s) 25-31, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2018.07.011

Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes

Autores: Juha T. Huiskonen
Publicado en: Bioscience Reports, Edición 38/2, 2018, ISSN 0144-8463
Editor: Kluwer Academic Publishers
DOI: 10.1042/bsr20170203

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Autores: Zhaoyang Sun, Kamel El Omari, Xiaoyu Sun, Serban L. Ilca, Abhay Kotecha, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 14814, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14814

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Autores: Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 15408, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15408

Structures of enveloped virions determined by cryogenic electron microscopy and tomography

Autores: Robert Stass, Weng M. Ng, Young Chan Kim, Juha T. Huiskonen
Publicado en: Complementary Strategies to Understand Virus Structure and Function, Edición 105, 2019, Página(s) 35-71, ISBN 9780-128184561
Editor: Elsevier
DOI: 10.1016/bs.aivir.2019.07.009

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

Autores: Ilona Rissanen, Robert Stass, Stefanie A. Krumm, Jeffrey Seow, Ruben J.G. Hulswit, Guido C. Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J. Doores, Juha T. Huiskonen, Thomas A. Bowden
Publicado en: bioRxiv, 2020
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.04.17.029876

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