Objective
Beyond the paradigm of the central dogma of biology lie a number of recently discovered elements that are nonetheless central to cellular function. Eukaryotic genomes express an unexpectedly wide variety of functional long transcripts that do not encode major proteins, called long non-coding RNAs (lncRNAs), whose functions are still poorly understood. More recent work has uncovered the prevalence of small open reading frames (smORFs) encoded within both mRNA and lncRNAs, only a few of which have evidence of active translation and function. The work in this proposal focuses on these relatively uncharacterized layers of biological regulation, and aims to harness the power of insect developmental genetics and the exquisite knowledge of axial patterning in embryos to probe the function of small peptides/lncRNA. Developmental gene networks in insects with varied modes of development have been studied in detail, allowing insights into how such networks have evolved. I will use a combination of state-of-the-art comparative genomics and transcriptome analysis, molecular genetics, biochemistry, and ribosome profiling to identify transcripts encoding putative small peptides with conserved features across insects, which represent novel components of developmental networks. This will be accompanied by genetic studies illuminating their functional interactions within developmental networks, including embryonic expression and loss of function phenotypes. Our approach to studying small peptides includes creation of innovative functional assays needed in the field, and is relevant to understanding the function of small peptides in all animals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7610001 Rehovot
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.