Regarding the selected case study, MuMoSiSt has surely achieved significant new knowledge about the history of the area, going considerably beyond the previous state of the art. The existing studies were almost entirely insufficient regarding the assessment of the actual state of the site throughout history. During the project, specific research was carried out in order to study the Temple's area during the Middle Ages and the Early Modern Age, with a specific attention to the Colonna estates, such as the so-called Palazzo dell'Olmo and Loggia dei Colonnesi, that partially occupied the ancient ruins of the eastern double stairway. A large number of unpublished documents primarily from the Colonna archives were collected, analysed and confronted with the coeval iconographic sources already present in the Census database. This analysis was implemented by means of a specific interpretation of archival and iconographic sources and relating them to more recent buildings in the area, on both the historical and constructive point of view, and especially to the re-modelling of Piazza del Quirinale with the interventions from the 17th to the 19th centuries. But the innovation of MuMoSiSt, as well as the improvement of the knowledge about the Temple of Serapis and its post-antique transformations, mainly consists of both the methodology applied and the strategy selected for the communication of the achieved goals. In fact, the different historiography sectors were investigated simultaneously, thus allowing the study of the area in all its complexity. This approach is addressed to the creation of a general methodology, able to involve and encourage cooperation between different kinds of scholars, to be applied in future larger studies dealing with multilayer monumental sites. Therefore, the definition of a tool able to facilitate multi-disciplinary research, is one of the most relevant goals achieved. The research covered the whole development period of the area by means of systematic data collection.