Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure

Project Information

Titin Signals

Grant agreement ID: 656636

DOI 10.3030/656636

Project closed

EC signature date 28 July 2015

Start date 1 July 2016

End date 31 December 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 239 860,80

EU contribution € 239 860,80

Coordinated by

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany

Deliverables

Open Research Data Pilot (1)

The summary of data generated in first 12 months of project

The summary of raw data and metadata generated in first 12 months of project

Publications

Peer reviewed articles (9)

HSPB7 is indispensable for heart development by modulating actin filament assembly

Author(s): Tongbin Wu, Yongxin Mu, Julius Bogomolovas, Xi Fang, Jennifer Veevers, Roberta B. Nowak, Christopher T. Pappas, Carol C. Gregorio, Sylvia M. Evans, Velia M. Fowler, Ju Chen
Published in: Proceedings of the National Academy of Sciences, Issue 114/45, 2017, Page(s) 11956-11961, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1713763114

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

Author(s): Xi Fang, Julius Bogomolovas, Tongbin Wu, Wei Zhang, Canzhao Liu, Jennifer Veevers, Matthew J. Stroud, Zhiyuan Zhang, Xiaolong Ma, Yongxin Mu, Dieu-Hung Lao, Nancy D. Dalton, Yusu Gu, Celine Wang, Michael Wang, Yan Liang, Stephan Lange, Kunfu Ouyang, Kirk L. Peterson, Sylvia M. Evans, Ju Chen
Published in: Journal of Clinical Investigation, Issue 127/8, 2017, Page(s) 3189-3200, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI94310

Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages

Author(s): Thomas Moore-Morris, Paola Cattaneo, Nuno Guimarães-Camboa, Julius Bogomolovas, Marta Cedenilla, Indroneal Banerjee, Mercedes Ricote, Tatiana Kisseleva, Lunfeng Zhang, Yusu Gu, Nancy D Dalton, Kirk L Peterson, Ju Chen, Michel Puceat, Sylvia M Evans
Published in: Circulation Research, 2017, Page(s) CIRCRESAHA.117.311490, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311490

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

Author(s): Cornelis J Boogerd, Xiaoming Zhu, Ivy Aneas, Noboru J Sakabe, Lunfeng Zhang, Debora R Sobreira, Lindsey E Montefiori, Julius Bogomolovas, Amelia C Joslin, Bin Zhou, Ju Chen, Marcelo Nobrega, Sylvia M Evans
Published in: Circulation Research, 2018, Page(s) CIRCRESAHA.118.311339, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.118.311339

The BAG3-dependent and -independent roles of cardiac small heat shock proteins

Author(s): Xi Fang, Julius Bogomolovas, Christa Trexler, Ju Chen
Published in: JCI Insight, Issue 4/4, 2019, ISSN 2379-3708
Publisher: JCI Insight
DOI: 10.1172/jci.insight.126464

PKC and PKN in heart disease

Author(s): Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G. dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
Published in: Journal of Molecular and Cellular Cardiology, Issue 128, 2019, Page(s) 212-226, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2019.01.029

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury

Author(s): Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Published in: International Journal of Cardiology, Issue 212, 2016, Page(s) 232-234, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2016.03.045

A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Author(s): Julijus Bogomolovas, Egidijus Šimoliūnas, Ieva Rinkūnaitė, Luka Smalinskaitė, Andrej Podkopajev, Daiva Bironaitė, Cleo-Aron Weis, Alexander Marx, Virginija Bukelskienė, Norbert Gretz, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Published in: BioMed Research International, Issue 2016, 2016, Page(s) 1-9, ISSN 2314-6133
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2016/1627184

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Author(s): Tiankun Zhou, Jennifer R. Fleming, Barbara Franke, Julius Bogomolovas, Igor Barsukov, Daniel J. Rigden, Siegfried Labeit, Olga Mayans
Published in: FEBS Letters, Issue 590/18, 2016, Page(s) 3098-3110, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.12362