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Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure

Deliverables

The summary of data generated in first 12 months of project

The summary of raw data and metadata generated in first 12 months of project

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Publications

HSPB7 is indispensable for heart development by modulating actin filament assembly

Author(s): Tongbin Wu, Yongxin Mu, Julius Bogomolovas, Xi Fang, Jennifer Veevers, Roberta B. Nowak, Christopher T. Pappas, Carol C. Gregorio, Sylvia M. Evans, Velia M. Fowler, Ju Chen
Published in: Proceedings of the National Academy of Sciences, Issue 114/45, 2017, Page(s) 11956-11961, ISSN 0027-8424
DOI: 10.1073/pnas.1713763114

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

Author(s): Xi Fang, Julius Bogomolovas, Tongbin Wu, Wei Zhang, Canzhao Liu, Jennifer Veevers, Matthew J. Stroud, Zhiyuan Zhang, Xiaolong Ma, Yongxin Mu, Dieu-Hung Lao, Nancy D. Dalton, Yusu Gu, Celine Wang, Michael Wang, Yan Liang, Stephan Lange, Kunfu Ouyang, Kirk L. Peterson, Sylvia M. Evans, Ju Chen
Published in: Journal of Clinical Investigation, Issue 127/8, 2017, Page(s) 3189-3200, ISSN 0021-9738
DOI: 10.1172/JCI94310

Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages


Published in: ISSN 0009-7330
DOI: 10.1161/circresaha.117.311490

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development


Published in: ISSN 0009-7330
DOI: 10.1161/CIRCRESAHA.118.311339

The BAG3-dependent and -independent roles of cardiac small heat shock proteins

Author(s): Xi Fang, Julius Bogomolovas, Christa Trexler, Ju Chen
Published in: JCI Insight, Issue 4/4, 2019, ISSN 2379-3708
DOI: 10.1172/jci.insight.126464

PKC and PKN in heart disease

Author(s): Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G. dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
Published in: Journal of Molecular and Cellular Cardiology, Issue 128, 2019, Page(s) 212-226, ISSN 0022-2828
DOI: 10.1016/j.yjmcc.2019.01.029

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury

Author(s): Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Published in: International Journal of Cardiology, Issue 212, 2016, Page(s) 232-234, ISSN 0167-5273
DOI: 10.1016/j.ijcard.2016.03.045

A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Author(s): Julijus Bogomolovas, Egidijus Šimoliūnas, Ieva Rinkūnaitė, Luka Smalinskaitė, Andrej Podkopajev, Daiva Bironaitė, Cleo-Aron Weis, Alexander Marx, Virginija Bukelskienė, Norbert Gretz, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Published in: BioMed Research International, Issue 2016, 2016, Page(s) 1-9, ISSN 2314-6133
DOI: 10.1155/2016/1627184

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Author(s): Tiankun Zhou, Jennifer R. Fleming, Barbara Franke, Julius Bogomolovas, Igor Barsukov, Daniel J. Rigden, Siegfried Labeit, Olga Mayans
Published in: FEBS Letters, Issue 590/18, 2016, Page(s) 3098-3110, ISSN 0014-5793
DOI: 10.1002/1873-3468.12362