Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure

Informations projet

Titin Signals

N° de convention de subvention: 656636

DOI 10.3030/656636

Projet clôturé

Date de signature de la CE 28 Juillet 2015

Date de début 1 Juillet 2016

Date de fin 31 Decembre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 239 860,80

Contribution de l’UE € 239 860,80

Coordonné par

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany

Livrables

Open Research Data Pilot (1)

The summary of data generated in first 12 months of project

The summary of raw data and metadata generated in first 12 months of project

Publications

Peer reviewed articles (9)

HSPB7 is indispensable for heart development by modulating actin filament assembly

Auteurs: Tongbin Wu, Yongxin Mu, Julius Bogomolovas, Xi Fang, Jennifer Veevers, Roberta B. Nowak, Christopher T. Pappas, Carol C. Gregorio, Sylvia M. Evans, Velia M. Fowler, Ju Chen
Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/45, 2017, Page(s) 11956-11961, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1713763114

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

Auteurs: Xi Fang, Julius Bogomolovas, Tongbin Wu, Wei Zhang, Canzhao Liu, Jennifer Veevers, Matthew J. Stroud, Zhiyuan Zhang, Xiaolong Ma, Yongxin Mu, Dieu-Hung Lao, Nancy D. Dalton, Yusu Gu, Celine Wang, Michael Wang, Yan Liang, Stephan Lange, Kunfu Ouyang, Kirk L. Peterson, Sylvia M. Evans, Ju Chen
Publié dans: Journal of Clinical Investigation, Numéro 127/8, 2017, Page(s) 3189-3200, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI94310

Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages

Auteurs: Thomas Moore-Morris, Paola Cattaneo, Nuno Guimarães-Camboa, Julius Bogomolovas, Marta Cedenilla, Indroneal Banerjee, Mercedes Ricote, Tatiana Kisseleva, Lunfeng Zhang, Yusu Gu, Nancy D Dalton, Kirk L Peterson, Ju Chen, Michel Puceat, Sylvia M Evans
Publié dans: Circulation Research, 2017, Page(s) CIRCRESAHA.117.311490, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311490

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

Auteurs: Cornelis J Boogerd, Xiaoming Zhu, Ivy Aneas, Noboru J Sakabe, Lunfeng Zhang, Debora R Sobreira, Lindsey E Montefiori, Julius Bogomolovas, Amelia C Joslin, Bin Zhou, Ju Chen, Marcelo Nobrega, Sylvia M Evans
Publié dans: Circulation Research, 2018, Page(s) CIRCRESAHA.118.311339, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.118.311339

The BAG3-dependent and -independent roles of cardiac small heat shock proteins

Auteurs: Xi Fang, Julius Bogomolovas, Christa Trexler, Ju Chen
Publié dans: JCI Insight, Numéro 4/4, 2019, ISSN 2379-3708
Éditeur: JCI Insight
DOI: 10.1172/jci.insight.126464

PKC and PKN in heart disease

Auteurs: Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G. dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
Publié dans: Journal of Molecular and Cellular Cardiology, Numéro 128, 2019, Page(s) 212-226, ISSN 0022-2828
Éditeur: Academic Press
DOI: 10.1016/j.yjmcc.2019.01.029

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury

Auteurs: Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Publié dans: International Journal of Cardiology, Numéro 212, 2016, Page(s) 232-234, ISSN 0167-5273
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2016.03.045

A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Auteurs: Julijus Bogomolovas, Egidijus Šimoliūnas, Ieva Rinkūnaitė, Luka Smalinskaitė, Andrej Podkopajev, Daiva Bironaitė, Cleo-Aron Weis, Alexander Marx, Virginija Bukelskienė, Norbert Gretz, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Publié dans: BioMed Research International, Numéro 2016, 2016, Page(s) 1-9, ISSN 2314-6133
Éditeur: Hindawi Publishing Corporation
DOI: 10.1155/2016/1627184

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Auteurs: Tiankun Zhou, Jennifer R. Fleming, Barbara Franke, Julius Bogomolovas, Igor Barsukov, Daniel J. Rigden, Siegfried Labeit, Olga Mayans
Publié dans: FEBS Letters, Numéro 590/18, 2016, Page(s) 3098-3110, ISSN 0014-5793
Éditeur: Elsevier BV
DOI: 10.1002/1873-3468.12362