[18F]Fluorination of alkylCF3 and alkylCF2CF3 chains-Application to hypoxia biomarkers for PET imaging.

Informazioni relative al progetto

HYPOXFLU

ID dell’accordo di sovvenzione: 658405

DOI 10.3030/658405

Progetto concluso il 3 Dicembre 2016

Data della firma CE 7 Aprile 2015

Data di avvio 16 Marzo 2015

Data di completamento 15 Marzo 2017

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 195 454,80

Contributo UE € 195 454,80

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Obiettivo

The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.

Campo scientifico

• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › clinical medicine › radiology › nuclear medicine
• natural sciences › chemical sciences › nuclear chemistry › radiochemistry
• medical and health sciences › clinical medicine › oncology
• natural sciences › chemical sciences › inorganic chemistry › halogens

Parole chiave

• Fluorine chemistry
• [18F]radiochemistry
• biomarkers

Programma(i)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Argomento(i)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Invito a presentare proposte

H2020-MSCA-IF-2014

Meccanismo di finanziamento

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinatore

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

• Contribution nette de l'UE: € 195 454,80
• Indirizzo: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Regno Unito
• Regione: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: € 195 454,80