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Theranostic Injectable Hydrogel for Glioblastoma

Obiettivo

Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults and is characterized by invariably fatal prognosis. Although the incidence of GBM is less than 10 to 100,000, the median survival of approximate 1 year from diagnosis makes it a considerable socio-economic burden. The presence of biological barriers for effective drug transport to the brain, the strong migrating-ability of the tumor and its rapid evolution into more aggressive and treatment-resistant variants, make GBM extremely hard to treat with traditional systemic chemotherapy. The HyGlio project proposes an ambitious bottom-up approach to build a multifunctional tool for long-term imaging and treatment of GBM, combining multiple treatment strategies, patient-specificity, and BBB bypassing in an all-in-one system. The system combines the advantages of: (i) Intracranial treatment, which maximizes efficacy while minimizing side effects; (ii) mild gelling conditions of the hydrogel, which reduce potential damages to the healthy tissue; (iii) increased drug penetration and selectivity due to the use of targeted polymer nanoparticles; (iv) Inhibition of molecular mechanisms involved in GBM spreading and aggressiveness; (iv) theranostic potential, due to the presence of magnetic resonance imaging, agents for rapid therapy adjustment according to patient’s needs.
The HyGlio project is expected to introduce innovative concepts and methodologies for the treatment of GBM, by providing advanced and promising tools for more efficient therapy and increased patient outcome.

Meccanismo di finanziamento

MSCA-IF-GF - Global Fellowships

Coordinatore

POLITECNICO DI TORINO
Contribution nette de l'UE
€ 244 269,00
Indirizzo
Corso Duca Degli Abruzzi 24
10129 Torino
Italia

Mostra sulla mappa

Regione
Nord-Ovest Piemonte Torino
Tipo di attività
Higher or Secondary Education Establishments
Contributo di paesi terzi
€ 0,00

Partner (1)

Partner

Le organizzazioni partner contribuiscono all’attuazione dell’azione, ma non sottoscrivono l’accordo di sovvenzione.

THE METHODIST HOSPITAL RESEARCH INSTITUTE
Stati Uniti
Contribution nette de l'UE
€ 0,00
Contributo di paesi terzi
€ 160 130,40