Periodic Reporting for period 1 - KINSELECT (Microtubule organisation and polarized transport of kinesins in neurons)
Periodo di rendicontazione: 2015-05-01 al 2017-04-30
Exploitation and dissemination: regarding this project, 6 seminars were given to the Department during my Marie Sklodowska-Curie fellowship. The work performed in the last two years will lead to two publications. First part of the work has already generated wide-spread enthusiasm at the various cell biology, neuroscience and advanced microscopy meetings where it has been presented (e.g. the EMBO conference on Microtubules, the European Neuroscience Meeting (FENS), the GRC on molecular motors, the EMBO Meeting, the European Microscopy Conference); and is under review in Neuron. The second part of this work is now finished and in preparation to be submitted in an open source high impact journal.
This work provides fundamental knowledge required to understand the molecular mechanisms involved in neurodegenerative diseases such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis. Therefore, it will contribute to a better understanding of brain functioning, meeting perfectly the priorities of the current research framework in the European Research Area. The outcome of this study might also provide new strategic approaches to counter such diseases or decrease the consequences for the concerned individuals.