Optical point of care system for heart failure mass screening

Información del proyecto

COSMOS

Identificador del acuerdo de subvención: 661484

DOI

10.3030/661484

Proyecto finalizado el 12 Octubre 2017

Fecha de la firma de la CE 13 Marzo 2015

Fecha de inicio 4 Mayo 2015

Fecha de finalización 23 Agosto 2018

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 185 076,00

Aportación de la UE

€ 185 076,00

Coordinado por

UNIVERSITE LYON 1 CLAUDE BERNARD
France

Objetivo

Diseases of the heart and circulatory system are the main cause of death in Europe (over 4 million deaths each year). In particular, heart failure (HF) accounts for almost 1.1 million deaths each year.
In early ’90 there was the formal recognition that inflammatory mediators are activated in the setting of HF by a sentinel description of inflammatory cytokines in patients with heart failure. After that, a growing interest in the role of biomarkers in regulating cardiac structure and function, particularly regarding their potential role in disease progression in heart failure, raised up. Nowadays, there are evidences on that.
Generally, biomarkers are determined mostly in plasma or in blood, rather than in saliva. In fact, despite of that very few of them have been currently studied in saliva, saliva has to be considered as an important diagnostic and prognostic medium for minimally invasive tools. Indeed a great progress in disclosing the complete salivary proteome has carried to the identification of more than 3000 different proteins.
Scope of this project is to develop a tool for HF-biomarkers detection through saliva. The idea is to combine the knowledge of the experienced researcher in microelectronics and CMOS imagers with the competences of the hosting laboratory on bioMEMs for biomarkers immobilization to develop an innovative point-of-care system for a fast and precise detection of HF-biomarkers. To this end the hosting institution and the experienced researcher complete each other and make the research and development on this cross related filed feasible. The proposed device will allow a mass screening for the prevention of HF and other pathologies related to the cardiovascular system.
Within this project, the experienced researcher will be able both to enlarge her knowledge in the design of CMOS imagers by implementing innovative photon detection techniques and to approach a growing branch of microelectronics, such as the bioMEMs one.

Ámbito científico (EuroSciVoc)

• ciencias naturales › ciencias biológicas › bioquímica › biomoléculas › proteínas › proteómica
• ciencias naturales › ciencias físicas › óptica › microscopía
• ciencias médicas y de la salud › medicina básica › patología
• ciencias naturales › ciencias físicas › electromagnetismo y electrónica › microelectrónica
• ciencias médicas y de la salud › medicina clínica › cardiología

Palabras clave

• BioMEMs
• optial readout
• point-of-care

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)
  

Régimen de financiación

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Convocatoria de propuestas

H2020-MSCA-IF-2014

Coordinador

UNIVERSITE LYON 1 CLAUDE BERNARD

• Aportación neta de la UEn: € 185 076,00
• Dirección: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 ; 69622 Villeurbanne Cedex ; Francia
• Región: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: € 185 076,00