Obiettivo Diseases of the heart and circulatory system are the main cause of death in Europe (over 4 million deaths each year). In particular, heart failure (HF) accounts for almost 1.1 million deaths each year. In early ’90 there was the formal recognition that inflammatory mediators are activated in the setting of HF by a sentinel description of inflammatory cytokines in patients with heart failure. After that, a growing interest in the role of biomarkers in regulating cardiac structure and function, particularly regarding their potential role in disease progression in heart failure, raised up. Nowadays, there are evidences on that. Generally, biomarkers are determined mostly in plasma or in blood, rather than in saliva. In fact, despite of that very few of them have been currently studied in saliva, saliva has to be considered as an important diagnostic and prognostic medium for minimally invasive tools. Indeed a great progress in disclosing the complete salivary proteome has carried to the identification of more than 3000 different proteins. Scope of this project is to develop a tool for HF-biomarkers detection through saliva. The idea is to combine the knowledge of the experienced researcher in microelectronics and CMOS imagers with the competences of the hosting laboratory on bioMEMs for biomarkers immobilization to develop an innovative point-of-care system for a fast and precise detection of HF-biomarkers. To this end the hosting institution and the experienced researcher complete each other and make the research and development on this cross related filed feasible. The proposed device will allow a mass screening for the prevention of HF and other pathologies related to the cardiovascular system.Within this project, the experienced researcher will be able both to enlarge her knowledge in the design of CMOS imagers by implementing innovative photon detection techniques and to approach a growing branch of microelectronics, such as the bioMEMs one. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesbasic medicinepathologynatural sciencesphysical scienceselectromagnetism and electronicsmicroelectronicsmedical and health sciencesclinical medicinecardiology Parole chiave BioMEMs optial readout point-of-care Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinatore UNIVERSITE LYON 1 CLAUDE BERNARD Contribution nette de l'UE € 185 076,00 Indirizzo BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex Francia Mostra sulla mappa Regione Auvergne-Rhône-Alpes Rhône-Alpes Rhône Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 185 076,00