Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres

Información del proyecto

BeadDiagnosis

Identificador del acuerdo de subvención: 665631

DOI

10.3030/665631

Proyecto cerrado

Fecha de la firma de la CE 7 Julio 2015

Fecha de inicio 1 Agosto 2015

Fecha de finalización 31 Enero 2017

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 149 972,00

Aportación de la UE

€ 149 972,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Periodic Reporting for period 1 - BeadDiagnosis (Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres)

Período documentado: 2015-08-01 hasta 2017-01-31

Resumen del contexto y de los objetivos generales del proyecto

There is currently no early detection system for neurological protein misfolding disorders (such as Alzheimer's and Parkinson's diseases) that would satisfy the demands for rapid, quantitative, flexible, and reproducible assays to study the aggregation of these disease-inducing proteins in biological samples. The project has established the feasibility of such a system, where emerging protein aggregates are confined in microdroplets that are formed in microfluidic devices and can be analysed by a variety of fluorescence-based methods (e.g. FACS, fluorescence lifetime analysis or in chip devices).