Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres

Informazioni relative al progetto

BeadDiagnosis

ID dell’accordo di sovvenzione: 665631

DOI

10.3030/665631

Progetto chiuso

Data della firma CE 7 Luglio 2015

Data di avvio 1 Agosto 2015

Data di completamento 31 Gennaio 2017

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 149 972,00

Contributo UE

€ 149 972,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Periodic Reporting for period 1 - BeadDiagnosis (Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres)

Periodo di rendicontazione: 2015-08-01 al 2017-01-31

Sintesi del contesto e degli obiettivi generali del progetto

There is currently no early detection system for neurological protein misfolding disorders (such as Alzheimer's and Parkinson's diseases) that would satisfy the demands for rapid, quantitative, flexible, and reproducible assays to study the aggregation of these disease-inducing proteins in biological samples. The project has established the feasibility of such a system, where emerging protein aggregates are confined in microdroplets that are formed in microfluidic devices and can be analysed by a variety of fluorescence-based methods (e.g. FACS, fluorescence lifetime analysis or in chip devices).