Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres

Projektinformationen

BeadDiagnosis

ID Finanzhilfevereinbarung: 665631

DOI

10.3030/665631

Projekt abgeschlossen

EK-Unterschriftsdatum 7 Juli 2015

Startdatum 1 August 2015

Enddatum 31 Januar 2017

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten

€ 149 972,00

EU-Beitrag

€ 149 972,00

Koordiniert durch

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Periodic Reporting for period 1 - BeadDiagnosis (Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres)

Berichtszeitraum: 2015-08-01 bis 2017-01-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

There is currently no early detection system for neurological protein misfolding disorders (such as Alzheimer's and Parkinson's diseases) that would satisfy the demands for rapid, quantitative, flexible, and reproducible assays to study the aggregation of these disease-inducing proteins in biological samples. The project has established the feasibility of such a system, where emerging protein aggregates are confined in microdroplets that are formed in microfluidic devices and can be analysed by a variety of fluorescence-based methods (e.g. FACS, fluorescence lifetime analysis or in chip devices).