Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) during Ebola virus infection in non-human primates humans

Risultati finali

publication 2

Various publications

Report modviro-immunological markers in NHPs

Report on the modelling of viro-immunological markers in NHPs

Publication scientific papers

Scientific papers published in the frame of WPs 1, 2, 3 & 4 activities

Report 1 educational activities and surveys REACTION!

Reports on the educational activities and surveys conducted under REACTION!

scientific documents on website plus discussion forum launch

Scientific documents addressing the current knowledge on the field (with a lay summary) published on website. A discussion forum on these topics is launched

Manuscript 2
Manual and toolkit

Manual and toolkit with key messages and knowledge translation strategies

Active dissemination

Active dissemination of relevant papers from REACTION! amongst all relevant stakeholders

Report on the antiviral efficacy of Favipiravir in humans
Report 2 educational activities and surveys REACTION!

Reports on the educational activities and surveys conducted under REACTION!

Manuscript 1
Report on Symposium

Report with main conclusions from the symposium on Sociocultural and historical context of Ebola virus disease and the response. Specific exchanges with Scientific Committee and IRB

publication 1

Various publications

report effect Favipiravir in mice

Report on the effect of treatment with Favipiravir in mice

Special issue

Edited special issue: “Ebola: the burdens of history. Lessons from the history of health crises in West Africa”, this will be based on a workshop.

All approvals package

All approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Software prediction Favipiravir treatment

Software for prediction of Favipiravir-based treatment regimens

Intervention draft

Drafting of an appropriate intervention to foster acceptable and sustainable forms of care, to be implemented in WP5

Pubblicazioni

The Humanitarian Response in Guinea during Ebola outbreak

Autori: Carémel, Jean François, Faye Sylvain, Ouédraogo Ramatou
Pubblicato in: The Politics of Fear: Médecins Sans Frontières and the West African Ebola Epidemic, 2017, ISBN 9780-190624477
Editore: Oxford University Press

"Pratiques de ""mobilisation de communates""dalns lurgence sanitaire par les humanitaires en Afrique de l'Ouest"

Autori: Faye Sylvain
Pubblicato in: Transition humanitaire en Côte d'Ivoire, 2017, Pagina/e 123 - 145, ISBN 9782-811117917
Editore: Karthala

Doing Science in an Emergency. Challenging clinical trial standards and producing care.

Autori: Frédéric Le Marcis, Daouda Sissoko, Xavier Anglaret and Denis Malvy
Pubblicato in: Localizing Standards, 2018
Editore: Vancouver UBC Press

L’« exceptionnalité » d’Ebola et les « réticences » populaires en Guinée-Conakry. Réflexions à partir d’une approche d’anthropologie symétrique

Autori: Sylvain Landry Faye
Pubblicato in: Anthropologie et Santé, Numero 11, 2015, ISSN 2111-5028
Editore: Anthropologie & Sante
DOI: 10.4000/anthropologiesante.1796

La mise en camp de la Guinée. Ebola et l'expérience postcoloniale

Autori: Gomez-Temesio Veronica; Le Marcis, Frédéric
Pubblicato in: L'Homme - Revue française d'anthropologie, Éditions de l'EHESS 2017, 2017, Pagina/e 57-90, ISSN 0439-4216
Editore: Editions de I'Ecole des Hautes Etudes en Sciences Sociales

Vaccination and blood sampling acceptability during Ramadan fasting month: A cross-sectional study in Conakry, Guinea

Autori: Nathan Peiffer-Smadja, Ramatou Ouedraogo, Eric D'Ortenzio, Papa Ndiaga Cissé, Zahra Zeggani, Abdoul Habib Beavogui, Sylvain Landry Faye, Frédéric Le Marcis, Yazdan Yazdanpanah, Vinh-Kim Nguyen
Pubblicato in: Vaccine, Numero 35/19, 2017, Pagina/e 2569-2574, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2017.03.068

Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Autori: Vincent Madelain, Jérémie Guedj, France Mentré, Thi Huyen Tram Nguyen, Frédéric Jacquot, Lisa Oestereich, Takumi Kadota, Koichi Yamada, Anne-Marie Taburet, Xavier de Lamballerie, Hervé Raoul
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 61/1, 2016, Pagina/e e01305-16, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/AAC.01305-16

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study

Autori: Daouda Sissoko, Sophie Duraffour, Romy Kerber, Jacques Seraphin Kolie, Abdoul Habib Beavogui, Alseny-Modet Camara, Géraldine Colin, Toni Rieger, Lisa Oestereich, Bernadett Pályi, Stephanie Wurr, Jeremie Guedj, Thi Huyen Tram Nguyen, Rosalind M Eggo, Conall H Watson, W John Edmunds, Joseph Akoi Bore, Fara Raymond Koundouno, Mar Cabeza-Cabrerizo, Lisa L Carter, Liana Eleni Kafetzopoulou, Eeva Kuis
Pubblicato in: The Lancet Global Health, Numero 5/1, 2017, Pagina/e e80-e88, ISSN 2214-109X
Editore: Elsevier BV
DOI: 10.1016/S2214-109X(16)30243-1

How to treat Ebola virus infections? A lesson from the field

Autori: Sophie Duraffour, Denis Malvy, Daouda Sissoko
Pubblicato in: Current Opinion in Virology, Numero 24, 2017, Pagina/e 9-15, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2017.03.003

Favipiravir for children with Ebola

Autori: Naïm Bouazza, Jean-Marc Treluyer, Frantz Foissac, France Mentré, Anne-Marie Taburet, Jérémie Guedj, Xavier Anglaret, Xavier de Lamballerie, Sakoba Keïta, Denis Malvy, Pierre Frange
Pubblicato in: The Lancet, Numero 385/9968, 2015, Pagina/e 603-604, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(15)60232-X

Dose regimen of favipiravir for Ebola virus disease

Autori: France Mentré, Anne-Marie Taburet, Jeremie Guedj, Xavier Anglaret, Sakoba Keïta, Xavier de Lamballerie, Denis Malvy
Pubblicato in: The Lancet Infectious Diseases, Numero 15/2, 2015, Pagina/e 150-151, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)71047-3

Ebola virus dynamics in mice treated with favipiravir

Autori: Vincent Madelain, Lisa Oestereich, Frederik Graw, Thi Huyen Tram Nguyen, Xavier de Lamballerie, France Mentré, Stephan Günther, Jeremie Guedj
Pubblicato in: Antiviral Research, Numero 123, 2015, Pagina/e 70-77, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2015.08.015

Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days

Autori: Boubacar Diallo, Daouda Sissoko, Nicholas J. Loman, Hadja Aïssatou Bah, Hawa Bah, Mary Claire Worrell, lya Saidou Conde, Ramata Sacko, Samuel Mesfin, Angelo Loua, Jacques Katomba Kalonda, Ngozi A. Erondu, Benjamin A. Dahl, Susann Handrick, Ian Goodfellow, Luke W. Meredith, Matthew Cotten, Umaru Jah, Raoul Emeric Guetiya Wadoum, Pierre Rollin, N'Faly Magassouba, Denis Malvy, Xavier Anglaret, Miles
Pubblicato in: Clinical Infectious Diseases, Numero 63/10, 2016, Pagina/e 1353-1356, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciw601

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

Autori: Daouda Sissoko, Cedric Laouenan, Elin Folkesson, Abdoul-Bing M’Lebing, Abdoul-Habib Beavogui, Sylvain Baize, Alseny-Modet Camara, Piet Maes, Susan Shepherd, Christine Danel, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Géraldine Colin, Hélène Savini, Joseph Akoi Bore, Frederic Le Marcis, Fara Raymond Koundouno, Frédéric Petitjean, Marie-Claire Lamah, Sandra Diederich, Alexis Tounkara, Gee
Pubblicato in: PLOS Medicine, Numero 13/3, 2016, Pagina/e e1001967, ISSN 1549-1676
Editore: PLOS Medicine
DOI: 10.1371/journal.pmed.1001967

Drug assessment in the Ebola virus disease epidemic in west Africa

Autori: Yazdan Yazdanpanah, Peter Horby, Johan van Griensven, France Mentre, Vinh-Kim Nguyen, Jean Marie Denis Malvy, Jake Dunning, Daouda Sissoko, Jean-Francois Delfraissy, Yves Levy
Pubblicato in: The Lancet Infectious Diseases, Numero 15/11, 2015, Pagina/e 1258, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(15)00344-8

Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials

Autori: Vincent Madelain, Thi Huyen Tram Nguyen, Anaelle Olivo, Xavier de Lamballerie, Jérémie Guedj, Anne-Marie Taburet, France Mentré
Pubblicato in: Clinical Pharmacokinetics, Numero 55/8, 2016, Pagina/e 907-923, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-015-0364-1

Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Autori: Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France Mentré
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 11/2, 2017, Pagina/e e0005389, ISSN 1935-2735
Editore: PLOS Neglected Tropical Diseases
DOI: 10.1371/journal.pntd.0005389

Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child

Autori: Daouda Sissoko, Mory Keïta, Boubacar Diallo, Negar Aliabadi, David L. Fitter, Benjamin A. Dahl, Joseph Akoi Bore, Fara Raymond Koundouno, Katrin Singethan, Sarah Meisel, Theresa Enkirch, Antonio Mazzarelli, Victoria Amburgey, Ousmane Faye, Amadou Alpha Sall, N’Faly Magassouba, Miles W. Carroll, Xavier Anglaret, Denis Malvy, Pierre Formenty, Raymond Bruce Aylward, Sakoba Keïta, Mamoudou Harouna
Pubblicato in: Clinical Infectious Diseases, 2017, Pagina/e ciw793, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciw793

« Traiter les corps comme des fagots » Production sociale de l’indifférence en contexte Ebola (Guinée)

Autori: Frédéric Le Marcis
Pubblicato in: Anthropologie et Santé, Numero 11, 2015, ISSN 2111-5028
Editore: Anthropologie & Santé
DOI: 10.4000/anthropologiesante.1907

Confrontations des « grammaires » de la «participation» communautaire en contexte d’urgence sanitaire d’Ebola en Guinée Conakry

Autori: Sylvain Laundry Faye
Pubblicato in: 2017
Editore: CODESRIA

Antiviral efficacy of favipiravir against Ebola virus in cynomolgus macaques.

Autori: Guedj J, Piorkowski G, Jacquot F, Madelain V, Nguyen T-H-T, Rodallec A, Gunther S, Carbonelle C, Mentré F, Raoul H, de Lamballerie X.
Pubblicato in: 2018
Editore: PLOS Medicine

An Ebola Photo Essay

Autori: Frédéric Le Marcis, Vinh-Kim Nguyen
Pubblicato in: Limn - Numero Number Five: Ebola's Ecologies, Numero Five, 2015
Editore: Limn

Ebola : chronique d’une catastrophe annoncée

Autori: Paul Benkimoun, Gilbert Potier, Michel Janssens, Frédéric Le Marcis et Antoine Petibon
Pubblicato in: Humanitaire, 2015, ISSN 2105-2522
Editore: Revue Humanitaire

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Risultati finali

Pubblicazioni

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