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DNA strand break repair and links to human disease

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Publications

Preparation and resolution of Holliday junction DNA recombination intermediates

Author(s): Rajvee Shah Punatar, Stephen C. West
Published in: Methods in Enzymology, Issue 600, 2018, Page(s) 569-590
DOI: 10.1016/bs.mie.2017.11.022

GEN1 endonuclease: Purification and nuclease assays

Author(s): Ying Wai Chan, Stephen C. West
Published in: Methods in Enzymology, Issue 600, 2018, Page(s) 527-542
DOI: 10.1016/bs.mie.2017.11.020

Analysis of Structure-Selective Endonuclease Activities From Yeast and Human Extracts

Author(s): Joao Matos, Stephen C. West
Published in: Methods in Enzymology, Issue 591, 2017, Page(s) 271-286
DOI: 10.1016/bs.mie.2017.03.005

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

Author(s): Ying Wai Chan, Kasper Fugger, Stephen C. West
Published in: Nature Cell Biology, Issue 20/1, 2018, Page(s) 92-103, ISSN 1465-7392
DOI: 10.1038/s41556-017-0011-1

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates

Author(s): Stephen C. West, Ying Wai Chan
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 82, 2018, Page(s) 034256, ISSN 0091-7451
DOI: 10.1101/sqb.2017.82.034256

SMX makes the cut in genome stability

Author(s): Haley D.M. Wyatt, Stephen C. West
Published in: Oncotarget, Issue 8/61, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.22420

The SMX DNA Repair Tri-nuclease

Author(s): Haley D.M. Wyatt, Rob C. Laister, Stephen R. Martin, Cheryl H. Arrowsmith, Stephen C. West
Published in: Molecular Cell, Issue 65/5, 2017, Page(s) 848-860.e11, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.01.031

A new class of ultrafine anaphase bridges generated by homologous recombination

Author(s): Ying Wai Chan, Stephen C. West
Published in: Cell Cycle, 2018, Page(s) 1-9, ISSN 1538-4101
DOI: 10.1080/15384101.2018.1515555

Resolution of single and double Holliday junction recombination intermediates by GEN1

Author(s): Shah Punatar, R. Martin, M. J. Wyatt, H. D. Chan, Y. W. West, S. C.
Published in: Proc Natl Acad Sci U S A, Issue 114, 2017, Page(s) 443-450, ISSN 0027-8424
DOI: 10.1073/pnas.1619790114

Resolution of Recombination Intermediates: Mechanisms and Regulation

Author(s): Stephen C. West, Miguel G. Blanco, Ying Wai Chan, Joao Matos, Shriparna Sarbajna, Haley D.M. Wyatt
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 80, 2015, Page(s) 103-109, ISSN 0091-7451
DOI: 10.1101/sqb.2015.80.027649

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis

Author(s): Kotynkova, K. Su, K. C. West, S. C. Petronczki, M.
Published in: Cell Reports, Issue 17, 2016, Page(s) 2672-2686, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.11.029

GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism

Author(s): Ying Wai Chan, Stephen West
Published in: Nucleic Acids Research, Issue 43/22, 2015, Page(s) 10882-10892, ISSN 0305-1048
DOI: 10.1093/nar/gkv1207