DNA strand break repair and links to human disease

Project Information

DNA2REPAIR

Grant agreement ID: 666400

DOI 10.3030/666400

Project closed

EC signature date 24 July 2015

Start date 1 September 2015

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 203 153,00

EU contribution € 2 203 153,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Publications

Peer reviewed articles (16)

Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability

Author(s): Young, S. J. West, S. C.
Published in: Crit. Rev. Biochem. Mol. Biol., Issue 56, 2021, Page(s) 157-177, ISSN 1549-7798
Publisher: Taylor and Francis
DOI: 10.1080/10409238.2021.1881433

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Author(s): Fugger, K. Bajrami, I. Silva Dos Santos, M. Young, S. J. Kunzelmann, S. Kelly, G. Hewitt, G. Patel, H. Goldstone, R. Carell, T. Boulton, S. J. MacRae, J. Taylor, I. A. West, S. C.
Published in: Science, Issue 372, 2021, Page(s) 156-165, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb4542

Defective ALC1 nucleosome remodelling confers PARPi sensitivity and synthetic lethality with HRD

Author(s): Hewitt, G. Borel, V. Segura-Bayona, S. Takaki, T. Ruis, P. Bellelli, R. Lehmann, L. C. Sommerova, L. Vancevska, A. Tomas-Loba, A. Zhu, K. Cooper, C. Fugger, K. Patel, H. Goldstone, R. Schneider-Luftman, D. Herbert, E. Stamp, G. Brough, R. Pettitt, S. Lord, C. J. West, S. C. Ahel, I. Ahel, D. Chapman, J. R. Deindl, S. Boulton, S. J.
Published in: Molecular Cell, Issue 81, 2021, Page(s) 767-783, ISSN 1097-4164
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.006

Tackling PARP inhibitor resistance

Author(s): Fugger, K. Hewitt, G. West, S. C. Boulton, S. J.
Published in: Trends Cancer, Issue 12, 2021, Page(s) 1102-1118, ISSN 2405-8025
Publisher: Cell Press
DOI: 10.1016/j.trecan.2021.08.007

Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2

Author(s): Kanagaraj, R. Mitter, R. Kantidakis, T. Edwards, M.M. Benitez, A. Chakravarty, P. Fu, B. Becherel, O. J. Yang, F. Lavin, M.F. Koren, A. Stewart, A. West, S.C.
Published in: Proc. Natl. Acad. Sci. USA, Issue 119, 2022, Page(s) e2114314119, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2114314119

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

Author(s): Ying Wai Chan, Kasper Fugger, Stephen C. West
Published in: Nature Cell Biology, Issue 20/1, 2018, Page(s) 92-103, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-017-0011-1

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates

Author(s): Stephen C. West, Ying Wai Chan
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 82, 2018, Page(s) 034256, ISSN 0091-7451
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.034256

SMX makes the cut in genome stability

Author(s): Haley D.M. Wyatt, Stephen C. West
Published in: Oncotarget, Issue 8/61, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.22420

The SMX DNA Repair Tri-nuclease

Author(s): Haley D.M. Wyatt, Rob C. Laister, Stephen R. Martin, Cheryl H. Arrowsmith, Stephen C. West
Published in: Molecular Cell, Issue 65/5, 2017, Page(s) 848-860.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2017.01.031

A new class of ultrafine anaphase bridges generated by homologous recombination

Author(s): Ying Wai Chan, Stephen C. West
Published in: Cell Cycle, 2018, Page(s) 1-9, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2018.1515555

Resolution of single and double Holliday junction recombination intermediates by GEN1

Author(s): Shah Punatar, R. Martin, M. J. Wyatt, H. D. Chan, Y. W. West, S. C.
Published in: Proc Natl Acad Sci U S A, Issue 114, 2017, Page(s) 443-450, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1619790114

Resolution of Recombination Intermediates: Mechanisms and Regulation

Author(s): Stephen C. West, Miguel G. Blanco, Ying Wai Chan, Joao Matos, Shriparna Sarbajna, Haley D.M. Wyatt
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 80, 2015, Page(s) 103-109, ISSN 0091-7451
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2015.80.027649

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis

Author(s): Kotynkova, K. Su, K. C. West, S. C. Petronczki, M.
Published in: Cell Reports, Issue 17, 2016, Page(s) 2672-2686, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.11.029

GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism

Author(s): Ying Wai Chan, Stephen West
Published in: Nucleic Acids Research, Issue 43/22, 2015, Page(s) 10882-10892, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv1207

MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

Author(s): Young, S. J. Sebald, M. Shah Punatar, R. Larin, M. Masino, L. Rodrigo-Brenni, M. C. Liang, C. C. West, S. C.
Published in: Cell Reports, Issue 33, 2020, Page(s) 108289, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108289

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Author(s): van Wietmarschen, Niek Sridharan, Sriram Nathan, William J. Tubbs, Anthony Chan, Edmond M. Callen, Elsa Wu, Wei Belinky, Frida Tripathi, Veenu Wong, Nancy Foster, Kyla Noorbakhsh, Javad Garimella, Kiran Cruz-Migoni, Abimael Sommers, Joshua A. Huang, Yongqing Borah, Ashir A. Smith, Jonathan T. Kalfon, Jeremie Kesten, Nikolas Fugger, Kasper Walker, Robert L. Dolzhenko, Egor Eberle, Michael A. Haywar
Published in: Nature, Issue 586, 2020, Page(s) 292-298, ISSN 1476-4687
Publisher: MacMillan
DOI: 10.1038/s41586-020-2769-8

Book chapters (3)

Preparation and resolution of Holliday junction DNA recombination intermediates

Author(s): Rajvee Shah Punatar, Stephen C. West
Published in: Methods in Enzymology, Issue 600, 2018, Page(s) 569-590
Publisher: Elsevier
DOI: 10.1016/bs.mie.2017.11.022

GEN1 endonuclease: Purification and nuclease assays

Author(s): Ying Wai Chan, Stephen C. West
Published in: Methods in Enzymology, Issue 600, 2018, Page(s) 527-542
Publisher: Elsevier
DOI: 10.1016/bs.mie.2017.11.020

Analysis of Structure-Selective Endonuclease Activities From Yeast and Human Extracts

Author(s): Joao Matos, Stephen C. West
Published in: Methods in Enzymology, Issue 591, 2017, Page(s) 271-286
Publisher: Elsevier
DOI: 10.1016/bs.mie.2017.03.005