DNA strand break repair and links to human disease

Publicaciones

Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability

Autores: Young, S. J. West, S. C.
Publicado en: Crit. Rev. Biochem. Mol. Biol., Edición 56, 2021, Página(s) 157-177, ISSN 1549-7798
Editor: Taylor and Francis
DOI: 10.1080/10409238.2021.1881433

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Autores: Fugger, K. Bajrami, I. Silva Dos Santos, M. Young, S. J. Kunzelmann, S. Kelly, G. Hewitt, G. Patel, H. Goldstone, R. Carell, T. Boulton, S. J. MacRae, J. Taylor, I. A. West, S. C.
Publicado en: Science, Edición 372, 2021, Página(s) 156-165, ISSN 1095-9203
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abb4542

Defective ALC1 nucleosome remodelling confers PARPi sensitivity and synthetic lethality with HRD

Autores: Hewitt, G. Borel, V. Segura-Bayona, S. Takaki, T. Ruis, P. Bellelli, R. Lehmann, L. C. Sommerova, L. Vancevska, A. Tomas-Loba, A. Zhu, K. Cooper, C. Fugger, K. Patel, H. Goldstone, R. Schneider-Luftman, D. Herbert, E. Stamp, G. Brough, R. Pettitt, S. Lord, C. J. West, S. C. Ahel, I. Ahel, D. Chapman, J. R. Deindl, S. Boulton, S. J.
Publicado en: Molecular Cell, Edición 81, 2021, Página(s) 767-783, ISSN 1097-4164
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.12.006

Tackling PARP inhibitor resistance

Autores: Fugger, K. Hewitt, G. West, S. C. Boulton, S. J.
Publicado en: Trends Cancer, Edición 12, 2021, Página(s) 1102-1118, ISSN 2405-8025
Editor: Cell Press
DOI: 10.1016/j.trecan.2021.08.007

Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2

Autores: Kanagaraj, R. Mitter, R. Kantidakis, T. Edwards, M.M. Benitez, A. Chakravarty, P. Fu, B. Becherel, O. J. Yang, F. Lavin, M.F. Koren, A. Stewart, A. West, S.C.
Publicado en: Proc. Natl. Acad. Sci. USA, Edición 119, 2022, Página(s) e2114314119, ISSN 1091-6490
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2114314119

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

Autores: Ying Wai Chan, Kasper Fugger, Stephen C. West
Publicado en: Nature Cell Biology, Edición 20/1, 2018, Página(s) 92-103, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-017-0011-1

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates

Autores: Stephen C. West, Ying Wai Chan
Publicado en: Cold Spring Harbor Symposia on Quantitative Biology, Edición 82, 2018, Página(s) 034256, ISSN 0091-7451
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.034256

SMX makes the cut in genome stability

Autores: Haley D.M. Wyatt, Stephen C. West
Publicado en: Oncotarget, Edición 8/61, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.22420

The SMX DNA Repair Tri-nuclease

Autores: Haley D.M. Wyatt, Rob C. Laister, Stephen R. Martin, Cheryl H. Arrowsmith, Stephen C. West
Publicado en: Molecular Cell, Edición 65/5, 2017, Página(s) 848-860.e11, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2017.01.031

A new class of ultrafine anaphase bridges generated by homologous recombination

Autores: Ying Wai Chan, Stephen C. West
Publicado en: Cell Cycle, 2018, Página(s) 1-9, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2018.1515555

Resolution of single and double Holliday junction recombination intermediates by GEN1

Autores: Shah Punatar, R. Martin, M. J. Wyatt, H. D. Chan, Y. W. West, S. C.
Publicado en: Proc Natl Acad Sci U S A, Edición 114, 2017, Página(s) 443-450, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1619790114

Resolution of Recombination Intermediates: Mechanisms and Regulation

Autores: Stephen C. West, Miguel G. Blanco, Ying Wai Chan, Joao Matos, Shriparna Sarbajna, Haley D.M. Wyatt
Publicado en: Cold Spring Harbor Symposia on Quantitative Biology, Edición 80, 2015, Página(s) 103-109, ISSN 0091-7451
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2015.80.027649

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis

Autores: Kotynkova, K. Su, K. C. West, S. C. Petronczki, M.
Publicado en: Cell Reports, Edición 17, 2016, Página(s) 2672-2686, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.11.029

GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism

Autores: Ying Wai Chan, Stephen West
Publicado en: Nucleic Acids Research, Edición 43/22, 2015, Página(s) 10882-10892, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv1207

MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

Autores: Young, S. J. Sebald, M. Shah Punatar, R. Larin, M. Masino, L. Rodrigo-Brenni, M. C. Liang, C. C. West, S. C.
Publicado en: Cell Reports, Edición 33, 2020, Página(s) 108289, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108289

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Autores: van Wietmarschen, Niek Sridharan, Sriram Nathan, William J. Tubbs, Anthony Chan, Edmond M. Callen, Elsa Wu, Wei Belinky, Frida Tripathi, Veenu Wong, Nancy Foster, Kyla Noorbakhsh, Javad Garimella, Kiran Cruz-Migoni, Abimael Sommers, Joshua A. Huang, Yongqing Borah, Ashir A. Smith, Jonathan T. Kalfon, Jeremie Kesten, Nikolas Fugger, Kasper Walker, Robert L. Dolzhenko, Egor Eberle, Michael A. Haywar
Publicado en: Nature, Edición 586, 2020, Página(s) 292-298, ISSN 1476-4687
Editor: MacMillan
DOI: 10.1038/s41586-020-2769-8

Preparation and resolution of Holliday junction DNA recombination intermediates

Autores: Rajvee Shah Punatar, Stephen C. West
Publicado en: Methods in Enzymology, Edición 600, 2018, Página(s) 569-590
Editor: Elsevier
DOI: 10.1016/bs.mie.2017.11.022

GEN1 endonuclease: Purification and nuclease assays

Autores: Ying Wai Chan, Stephen C. West
Publicado en: Methods in Enzymology, Edición 600, 2018, Página(s) 527-542
Editor: Elsevier
DOI: 10.1016/bs.mie.2017.11.020

Analysis of Structure-Selective Endonuclease Activities From Yeast and Human Extracts

Autores: Joao Matos, Stephen C. West
Publicado en: Methods in Enzymology, Edición 591, 2017, Página(s) 271-286
Editor: Elsevier
DOI: 10.1016/bs.mie.2017.03.005

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