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Common mechanisms and pathways in Stroke and Alzheimer's disease.

Project description

Stroke and Alzheimer’s disease: partners in crime?

The co-occurrence of stroke and Alzheimer's disease (AD) has long been acknowledged, suggesting the presence of similar causes and mechanisms. With a significant proportion of stroke survivors developing dementia and many elderly individuals with AD experiencing strokes, there is a need to understand the connection and origins of these disorders. The EU-funded CoSTREAM project aims to bridge this knowledge gap and shed light on the relationship between stroke and AD. Researchers will study common pathways, hoping to identify new biomarkers for the intertwined nature of these disorders. Results will improve prevention and treatment strategies for patients.


Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.

Call for proposal


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Sub call


Funding Scheme



Net EU contribution
€ 1 098 750,00
Dr molewaterplein 40
3015 GD Rotterdam

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West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (12)