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Common mechanisms and pathways in Stroke and Alzheimer's disease.

Objectif

Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.

Appel à propositions

H2020-PHC-2015-two-stage
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Coordinateur

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Adresse
Dr Molewaterplein 40
3015 GD Rotterdam
Pays-Bas
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 098 750

Participants (10)

KING'S COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 476 228,75
Adresse
Strand
WC2R 2LS London
Type d’activité
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution de l’UE
€ 509 946,25
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
Type d’activité
Higher or Secondary Education Establishments
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Autriche
Contribution de l’UE
€ 323 750
Adresse
Am Gestade 1
1010 Wien
Type d’activité
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Allemagne
Contribution de l’UE
€ 510 000
Adresse
Geschwister Scholl Platz 1
80539 Muenchen
Type d’activité
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 256 250
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
MIMETAS BV
Pays-Bas
Contribution de l’UE
€ 509 625
Adresse
Jh Oortweg 19
2333CH Leiden
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT PASTEUR DE LILLE FONDATION
France
Contribution de l’UE
€ 324 875
Adresse
Rue Du Professeur Calmette 1
59019 Lille
Type d’activité
Research Organisations
UNIVERSITEIT LEIDEN
Pays-Bas
Contribution de l’UE
€ 409 510
Adresse
Rapenburg 70
2311 EZ Leiden
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Suisse
Contribution de l’UE
€ 0
Adresse
Rue Du General Dufour 24
1211 Geneve
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITE DE BORDEAUX
France
Contribution de l’UE
€ 171 250
Adresse
Place Pey Berland 35
33000 Bordeaux
Type d’activité
Higher or Secondary Education Establishments